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| 1 | Recent advancement on technical requirements for grid integration of wind power显示文摘The installation of wind energy has experienced rapid development during recent years.As a result,the operation of power system can be greatly affected.Therefore,the operators of different countries have formulated the grid codes which reinforce technical requirements for wind power plants.In this paper,recent grid codes published in different countries have been carefully reviewed.The basic requirements of active power control and reactive power compensation,both of which have particular influence on wind power plants operation,are focused on.Based on this review,it is understood that with the increasing integration of wind energy,there is a worldwide trend to regulate the performance of wind power plants so that they can contribute to the stability and reliability of power system. | Xiaoge LIU Zhao XU Kit Po WONG | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 19 |
| 2 | Neuroprotective effects of autophagy inhibition on hippocampal glutamate receptor subunits after hypoxia-ischemia-induced brain damage in newborn rats显示文摘Autophagy has been suggested to participate in the pathology of hypoxic-ischemic brain damage(HIBD).However,its regulatory role in HIBD remains unclear and was thus examined here using a rat model.To induce HIBD,the left common carotid artery was ligated in neonatal rats,and the rats were subjected to hypoxia for 2 hours.Some of these rats were intraperitoneally pretreated with the autophagy inhibitor 3-methyladenine(10 m M in 10 μL) or the autophagy stimulator rapamycin(1 g/kg) 1 hour before artery ligation.Our findings demonstrated that hypoxia-ischemia-induced hippocampal injury in neonatal rats was accompanied by increased expression levels of the autophagy-related proteins light chain 3 and Beclin-1 as well as of the AMPA receptor subunit GluR 1,but by reduced expression of GluR 2.Pretreatment with the autophagy inhibitor 3-methyladenine blocked hypoxia-ischemia-induced hippocampal injury,whereas pretreatment with the autophagy stimulator rapamycin significantly augmented hippocampal injury.Additionally,3-methyladenine pretreatment blocked the hypoxia-ischemia-induced upregulation of Glu R1 and downregulation of GluR2 in the hippocampus.By contrast,rapamycin further elevated hippocampal Glu R1 levels and exacerbated decreased GluR2 expression levels in neonates with HIBD.Our results indicate that autophagy inhibition favors the prevention of HIBD in neonatal rats,at least in part,through normalizing Glu R1 and GluR2 expression. | Li-xiao Xu Xiao-juan Tang Yuan-yuan Yang Mei Li Mei-fang Jin Po Miao Xin Ding Ying Wang Yan-hong Li Bin Sun Xing Feng | 2017 | Neural Regeneration Research2017，12，3： | 12 |
| 3 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 4 | Overexpression of carbonic anhydrase Ⅱ and Ki-67 proteins in prognosis of gastrointestinal stromal tumors显示文摘AIM: To investigate the expression and prognostic value of carbonic anhydrase Ⅱ (CA Ⅱ) and Ki-67 in gastrointestinal stromal tumors (GISTs). METHODS: One hundred and thirteen GIST patients admitted to Chinese People's Liberation Army General Hospital from January 2004 to December 2010 were retrospectively followed up, and immunohistochemistry was used to detect CA Ⅱ, Ki-67 and CD117 expression in tumor samples. The survival rates of the patients were analyzed using the Kaplan-Meier method. Log-rank test, χ 2 test and Cox proportional hazards model were used to determine the relationships between CA Ⅱ, Ki-67 and CD117 expression and prognostic value in GISTs. RESULTS: The survival rates at 1, 3 and 5 years were 90.0%, 82.0% and 72.0% in all patients. However, in patients with positive CA Ⅱ or Ki-67, the survival rates were 92.0%, 83.0% and 77.0% or 83.0%, 66.6% and 53.0%, respectively. Compared with the negative groups, the survival rates in the positive groups were significantly lower (CA Ⅱ log-rankP = 0.000; Ki-67 logrank P = 0.004). Multivariate Cox analysis revealed that CA Ⅱ, CD117 and Ki-67 were considerable immune factors in prognosis of GIST patients (CA Ⅱ P = 0.043; CD117 P = 0.042; Ki-67 P = 0.007). Besides, tumor diameter, mitotic rate, tumor site, depth of invasion, complete resection, intraoperative rupture, and adjuvant therapy were important prognosis predictive factors. Our study indicated that CA Ⅱ had strong expression in GISTs and the prognosis of GISTs with high CA Ⅱ expression was better than that of GISTs with low or no expression, suggesting that CA Ⅱ is both a diagnostic and prognostic biomarker for GIST. CONCLUSION: CA Ⅱ and Ki-67 are significant prognostic factors for GISTs. CA Ⅱ associated with neovascular endothelia could serve as a potential target for cancer therapy. | Li-Cheng Liu Wen-Tong Xu Xin Wu Po Zhao Ya-Li Lv Lin Chen | 2013 | World Journal of Gastroenterology2013，19，16： | 5 |
| 5 | Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants显示文摘这当前的代表性的研究 40 年并且在上面在 euthyroid 汉语人口之中调查在甲状腺荷尔蒙和外部动脉疾病(垫) 之间的关系。浆液免费 triiodothyronine (FT3 ) ,免费甲状腺素(FT4 ) ,刺激甲状腺的荷尔蒙(TSH ) ,和甲状腺抗体被测量。垫被定义为脚关节臂的索引(ABI )< 0.9。有 91 (2.9%) 在 3,148 euthyroid 之中的垫案例学习参加者。参加者在有的 FT3 和 free-triiodothyronine-to-free-thyroxin (FT3/FT4 比率) 最高方照流行的垫的减少的风险(调整 multivariate 的机会比率, 95% 信心间隔:0.32, 0.15-0.62,为趋势 = 的 P 0.01 和 0.31, 0.13-0.66,为趋势 = 的 P 0.004,分别地) 与那些相比在里面最低方照。得出结论, FT3 层次和 FT3/FT4 比率相反地 40 年并且在上面在 euthyroid 汉语人口与流行的垫被联系。 | WANG Po DU Rui LIN Lin DING Lin PENG Kui XU Yu XU Min BI Yu Fang WANG Wei Qing NING Guang LU Jie Li | 2017 | Biomedical and Environmental Sciences2017，30，2： | 5 |
| 6 | The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage显示文摘Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine,Soochow University,China(approval No.XD-2016-1)on January 15,2016. | Ning Sha Hua-Wei Wang Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang Wen-Jing Zhu Yuan-Yuan Gao Xing Feng Xin Ding | 2021 | Neural Regeneration Research2021，16，10： | 4 |
| 7 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 8 | Therapeutic effect of autologous concentrated growth factor on lower-extremity chronic refractory wounds:A case report显示文摘BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds. | Po Liu Yang Liu Chang-Neng Ke Wei-Shan Li Yue-Ming Liu Shi Xu | 2021 | World Journal of Clinical Cases2021，9，18： | 3 |
| 9 | Compressional Wave Velocities in Some Volcanic Rocks at Pressure up to 4.5 GPa显示文摘INTRODUCTIONThecompressionalwavevelocity(vp)inrockmeasuredathighpressureandhightemperatureisofsignificantimpor-tancetoelucida... | Zhou Wenge Zhao Zhidan Xie Hongsen Li Yuwen Guo Jie Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002 Xu Ji ’an Institute of Earth Sciences, Academia Sinica, Nankang PO Box1 55, Taipei, Taiwan 115 | 1998 | Journal of Earth Science1998，17，2： | 3 |
| 10 | Hippocampus is more vulnerable to neural damages induced by repeated sevoflurane exposure in the second trimester than other brain areas显示文摘During the rapidly developing and sensitive period of the central nervous system (CNS), a harmful stimulus may have serious consequences. The effect of anesthetic exposure on the development of the offspring’s CNS during pregnancy is still unclear and has been widely concerned. In the present study, we compared the susceptibility of the hippocampus with those of other brain regions in offsprings when the mother mice were exposed to repeated sevoflurane. We found that other than affecting motor sensation, emotion, or social behavior of offspring mice, repeated sevoflurane exposure induced significant memory deficiency. Compared with other brain regions, the hippocampus, which is the key component of the brain serving for learning and memory, was more vulnerable to repeated sevoflurane exposure. We also found that repeated sevoflurane exposure to mother mice could inhibit the axon development of hippocampal neurons. We also predicted that N6-methyladenosine modification of mRNA might play an essential role in the vulnerability of the hippocampus to sevoflurane, while the underlying cellular mechanism needs to be explored in the future. Our study may provide a new perspective for studying the mechanism of hippocampus-specific injury induced by sevoflurane exposure. | Bing Chen Yanjun Liu Yirong Cai Dan Tang Saihong Xu Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 11 | Establishment of a diagnostic model of coronary heart disease in elderly patients with diabetes mellitus based on machine learning algorithms显示文摘OBJECTIVE To establish a prediction model of coronary heart disease(CHD)in elderly patients with diabetes mellitus(DM)based on machine learning(ML)algorithms.METHODS Based on the Medical Big Data Research Centre of Chinese PLA General Hospital in Beijing,China,we identified a cohort of elderly inpatients(≥60 years),including 10,533 patients with DM complicated with CHD and 12,634 patients with DM without CHD,from January 2008 to December 2017.We collected demographic characteristics and clinical data.After selecting the important features,we established five ML models,including extreme gradient boosting(XGBoost),random forest(RF),decision tree(DT),adaptive boosting(Adaboost)and logistic regression(LR).We compared the receiver operating characteristic curves,area under the curve(AUC)and other relevant parameters of different models and determined the optimal classification model.The model was then applied to 7447 elderly patients with DM admitted from January 2018 to December 2019 to further validate the performance of the model.RESULTS Fifteen features were selected and included in the ML model.The classification precision in the test set of the XGBoost,RF,DT,Adaboost and LR models was 0.778,0.789,0.753,0.750 and 0.689,respectively;and the AUCs of the subjects were 0.851,0.845,0.823,0.833 and 0.731,respectively.Applying the XGBoost model with optimal performance to a newly recruited dataset for validation,the diagnostic sensitivity,specificity,precision,and AUC were 0.792,0.808,0.748 and 0.880,respectively.CONCLUSIONS The XGBoost model established in the present study had certain predictive value for elderly patients with DM complicated with CHD. | Hu XU Wen-Zhe CAO Yong-Yi BAI Jing DONG He-Bin CHE Po BAI Jian-Dong WANG Feng CAO Li FAN | 2022 | Journal of Geriatric Cardiology2022，19，6： | 3 |
| 12 | Growth of cucumber seedlings in different varieties as affected by light environment显示文摘High-quality cucumber seedlings are a prerequisite for ensuring high yield of cucumbers.With the continuous increase of cucumber planting area in China,the demand for high-quality cucumber seedlings is also increasing.One of the important ways to improve the quality of cucumber seedlings is to improve the light environment by using artificial light source.In this study,three cucumber seedlings(cv.Jintong,cv.Yunv and cv.Xiazhiguang)were grown for 23 d under eight levels of daily light integral(DLI)at 4.3 mol/(m^(2)·d),8.6 mol/(m^(2)·d),10.1 mol/(m^(2)·d),13.0 mol/(m^(2)·d),5.8 mol/(m^(2)·d),11.5 mol/(m^(2)·d),14.4 mol/(m^(2)·d)and 17.3 mol/(m^(2)·d),respectively.The results showed that when DLI was 14.4 mol/(m^(2)·d),the seedling height,stem diameter,total leaf area and shoot dry/fresh weight of all three cucumber cultivars reached the maximum,while hypocotyl length decreased with the increase of light intensity.When DLI was 14.4 mol/(m^(2)·d),Jintong and Xiazhiguang had the highest health index,which were 49.29 and 28.56,respectively,while that of Yunv was 81.59(DLI=14.4 mol/(m^(2)·d)).With the increase of DLI,the photosynthetic capacity of cucumber increases gradually.The highest net photosynthetic rate was shown at DLI of 14.4 mol/(m^(2)·d),while the chlorophyll content of cucumber seedlings of all three cultivars were less affected by DLI.Jintong and Yunv had the highest chlorophyll content when DLI was 8.6 mol/(m^(2)·d)because they were adapted to low-light environment.In conclusion,the DLI of 14.4 mol/(m^(2)·d)for Jintong and Xiazhiguang,while that of 17.3 mol/(m^(2)·d)for Yunv are suggested for the light environment design of factory-cultivated seedling for cucumber. | Fang Ji Siqi Wei Nan Liu Lijun Xu Po Yang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 2 |
| 13 | A Real-time Monitoring System Based on ZigBee and 4G Communications for Photovoltaic Generation显示文摘A novel real-time monitoring system for photovoltaic(PV)generation is presented in this paper.Internet of Things(IoT)integrated with cloud servers and terminal applications allow the remote monitoring of centralized or distributed pho-tovoltaic systems.The proposed system could realize the net-working communication of multiple nodes based on ZigBee,and upload the operational data to the cloud server via a 4G communications network.Then,the server selects three-phase current as the sample sets from the uploaded data to set up a composite current characteristic combining wavelet packet en-ergy with waveform parameter,and establishes a fault diagnosis model based on the probabilistic neural network to analyze the health status of the PV inverter online.This method requires little sampling frequency without an extra signal and saves the cost of local devices by placing online diagnostics on the server-side.In addition,the user could query and store the running information of the PV systems through the personal computer-side web or mobile phone with remote control.This article presents the hardware design of ZigBee and the 4G module,and composition of the diagnosis model for open circuit failure of the PV inverter through the cloud server,building the user software at the application layer.The final experimental results show that the proposed system has better communication performance and higher diagnostic accuracy in real-time monitoring. | Kun Xia Jiawen Ni Yanhong Ye Po Xu Yiming Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 2 |
| 14 | Relationship between loss of heterozygosity of microsatellite on DCC gene and prognosis of colorectal adenocarcinoma显示文摘RelationshipbetweenlossofheterozygosityofmicrosateliteonDCCgeneandprognosisofcolorectaladenocarcinomaZHAOPo1,HUYingChuan2... | ZHAO Po 1, HU Ying Chuan 2, WANG De Wen 3, WANG Zhi Ping 3, XU Xin Zhao 4, YI Ping Yong 2, GAO Ya Bing 3 and YANG Guang Hua 2 | 1997 | World Journal of Gastroenterology1997，3，2： | 2 |
| 15 | Adaptive motion tracking block matching algorithms for video coding显示文摘 | XU J B PO L M CHEUNG C K | 1999 | IEEE Trans on Circuits and System for Video Technology1999，9，7： | 1 |
| 16 | Adaptive motion tracking block matching algorithms for video coding显示文摘 | XU Jie-bin PO Lai-man Cheung C K | 1999 | IEEE Trans on Circuits and Systems for Video Technology1999，9，7： | 1 |
| 17 | Adaptive motion tracking block matching algorithms for video coding 显示文摘 | XU Jiebin PO Laiman CHEUNG Chok Kwan | 1999 | IEEE Transactions on Circuits and Systems for Video Technology1999，9，7： | 1 |
| 18 | Adaptive motion tracking block matching algorithms for video coding显示文摘 | Xu J B Po L M Cheung C K | 1999 | IEEE Trans Circuits Syst Video Technol1999，9，7： | 1 |
| 19 | Additive Enhanced Crystallization of Solution‐Processed Perovskite for Highly Efficient Planar‐Heterojunction Solar Cells显示文摘 | Po‐Wei Liang Chien‐Yi Liao Chu‐Chen Chueh Fan Zuo Spencer T. Williams Xu‐Kai Xin Jiangjen Lin Alex K.‐Y. Jen | 2014 | Adv. Mater2014，，22： | 1 |
| 20 | Analysis of Raman and thermal effects in kilowatt fiber lasers 显示文摘 | WANG Y XU Ch Q PO H | 2004 | Opt Commun2004，242，： | 1 |
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