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| 1 | Efficient genome editing in plants using a CRISPR/Cas system显示文摘 | Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu | 2013 | Cell Research2013，23，10： | 211 |
| 2 | Current cancer situation in China:good or bad news from the 2018 Global Cancer Statistics?显示文摘Cancer is the leading cause of death in China and depicting the cancer pattern of China would provide basic knowhows on how to tackle it more effectively.In this study we have reviewed several reports of cancer burden,including the Global cancer statistics 2018 and Cancer statistics in China,2015,along with the GLOBCAN 2018 online database,to investigate the differences of cancer patterns between China,the United States(USA)and the United Kingdom(UK).An estimated 4.3 million new cancer cases and 2.9 million new cancer deaths occurred in China in 2018.Compared to the USA and UK,China has lower cancer incidence but a 30%and 40%higher cancer mortality than the UK and USA,among which 36.4%of the cancer-related deaths were from the digestive tract cancers(stomach,liver,and esophagus cancer)and have relatively poorer prognoses.In comparison,the digestive cancer deaths only took up≤5%of the total cancer deaths in either USA or UK.Other reasons for the higher mortality in China may be the low rate of early-stage cancers at diagnosis and non-uniformed clinical cancer treatment strategies performed by different regions.China is undergoing the cancer transition stage where the cancer spectrum is changing from developing country to developed country,with a rapidly increase cancer burden of colorectal,prostate,female breast cancers in addition to a high occurrence of infection-related and digestive cancers.The incidence of westernized lifestyle-related cancers in China(i.e.colorectal cancer,prostate,bladder cancer)has risen but the incidence of the digestive cancers has decreased from 2000 to 2011.An estimated 40%of the risk factors can be attributed to environmental and lifestyle factors either in China or other developed countries.Tobacco smoking is the single most important carcinogenic risk factor in China,contributing to~24.5%of cancers in males.Chronic infection is another important preventable cancer contributor which is responsible for~17%of cancers.Comprehensive prevention and control strategies in China should include effective tobacco-control policy,recommendations for healthier lifestyles,along with enlarg-ing the coverage of effective screening,educating,and vaccination programs to better sensitize greater awareness control to the general public. | Rui-Mei Feng Yi-Nan Zong Su-Mei Cao Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 675 |
| 3 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 4 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 5 | Surveillance of Mycoplasma pneumoniae infection among children in Beijing from 2007 to 2012显示文摘 | Zhao Hanqing Li Shaoli Cao Ling Yuan Yi Xue Guanhua Feng Yanling Yan Chao Wang Liqiong Fan Zhaoyang Sun Hongmei | 2014 | Chinese Medical Journal2014，，7： | 61 |
| 6 | Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway显示文摘绝经后的骨质疏松症严重地使受危险人的健康。没有副作用,寻找治疗学的药必要性大。我们的学习被设计调查是否 resveratrol, SIRT1 的收缩筋,能在骨质疏松症上并且到有有利效果探索内在的机制。老鼠骨质疏松症模型(卵巢切除术组, OVX ) 被双边的卵巢切除术建立。resveratrol 的三不同剂量被使用:5 mg/kg/d (低剂量,物件 LD ), 25 mg/kg/d (开媒介,物件 MD ), 和 45 mg/kg/d (开高度,物件 HD ) 。结果显示出那物件 LD 没在 OVX 改变上显示出任何重要效果,当时物件 MD 和物件 HD 显著地提高了骨质疏松症导致的减少的骨头矿物质密度(物件 MD 0.205 吗? | Jing Feng Shuai Liu Sai Ma Jian Zhao Wei Zhang Wei Qi Pengchong Cao Zheng Wang Wei Lei | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 70 |
| 7 | Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients显示文摘AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three Chinese liver centers.Steatosis was categorized as S0:<5%;S1:5%-33%;S2:34%-66%;or S3:≥67%,according to the nonalcoholic fatty liver disease(NAFLD)activity score.The FibroScan?502 equipped with the M probe(Echosens,Paris,France)was used to capture both CAP and liver stiffness measurement values simultaneously.Receiver operating characteristic curves were plotted,and the areas under the curves were calculated to determine the diagnostic efficacy.The accuracy of the CAP values at the optimal thresholds was defined by maximizing the sum of sensitivity and specificity(maximum Youden index).RESULTS:A total of 152 patients were recruited,including 52(34.2%)patients with NAFLD and 100(65.8%)with chronic hepatitis B(CHB)virus infection.After adjustment,the steatosis grade(OR=37.12;95%CI:21.63-52.60,P<0.001)and body mass index(BMI,OR=6.20;95%CI:2.92-9.48,P<0.001)were found independently associated with CAP by multivariate linear regression analysis.CAP was not influenced by inflammation,fibrosis or aetiology.The median CAP values and interquartile ranges among patients with S0,S1,S2 and S3 steatosis were 211(181-240)dB/m,270(253-305)dB/m,330(302-360)dB/m,and 346(313-363)dB/m,respectively.The cut-offs for the CAP values in all patients with steatosis≥5%,≥34%and≥67%were 253 dB/m,285 dB/m and 310 dB/m,respectively.The areas under the curves were 0.92,0.92and 0.88 for steatosis≥5%,≥34%and≥67%,respectively.No significant differences were found in the CAP values between the NAFLD group and the CHB group in each steatosis grade.CONCLUSION:CAP appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis,but is limited by BMI. | Feng Shen Rui-Dan Zheng Yu-Qiang Mi Xiao-Ying Wang Qin Pan Guang-Yu Chen Hai-Xia Cao Ming-Li Chen Liang Xu Jian-Neng Chen Yi Cao Rui-Nan Zhang Lei-Ming Xu Jian-Gao Fan | 2014 | World Journal of Gastroenterology2014，20，16： | 55 |
| 8 | Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR显示文摘瞄准:调查杂种狗枯茗的颠倒效果在上多,在一个抵抗的人的胃的癌房间的药抵抗(MDR ) 排队。方法:长春新碱(VCR ) 的细胞毒素的效果被 MTT 试金评估。VCR 导致的房间 apoptosis 被染色的 propidium 碘化物(PI ) 决定流动血细胞计数(FCM ) 和用吖啶橙(AO ) 的词法试金 /ethidium 溴化物(EB ) 双染色。P-glycoprotein (P-gp ) 功能被 rhodamine123 (Rh123 ) 的累积和流出用 FCM 表明。P-gp 的表示和 caspase-3 的激活被 FCM 用结合的荧光黄异硫氰酸盐(FITC ) 测量 anti-P-gp 和劈开反的 caspase-3 抗体分别地。结果:在 5 micromol/L, 10 micromol/L,或 20 micromol/L 的集中,姜黄色素没在胃的癌房间线(SGC7901 ) 或它的 VCR 抵抗的变体房间衬里的一个父母人(SGC7901/VCR ) 上有细胞毒素的效果。SGC7901/VCR 房间的 VCR-IC50 价值是多于 SGC7901cells 的 45 次, SGC7901/VCR 房间显示出 apoptotic 抵抗到 VCR。与 5 micromol/L, 10 micromol/L,或 20 micromol/L 杂种狗枯茗对待的 SGC7901/VCR 房间减少了以一种剂量依赖者方式的 VCR 和支持的调停 VCR 的 apoptosis 的 IC50 价值。姜黄色素(10 micromol/L ) 增加了 Rh123 累积并且在 SGC7901/VCR 房间禁止了 Rh123 的流出,但是没在 SGC7901 房间改变 Rh123 的累积和流出。P-gp 完了在 SGC7901/VCR 表示了房间,而它低与杂种狗枯茗(10 micromol/L ) 在一个 24-h 处理以后调整了。独自与 1 mumol/L VCR 对待的抵抗房间在 44% 增加的抵抗房间线相对 caspase-3 的 SGC7901 房间,而是激活看了 caspase-3 激活的 77% 底层房间什么时候与杂种狗枯茗在联合与 VCR 被对待。结论:姜黄色素能颠倒人的胃的癌 SGC7901/VCR 房间线的 MDR。这可能与减少的 P-gp 被联系函数和表达式,和在 MDR 房间的 caspase-3 激活的提升。 | Xiao-qing TANG Hu BI Jian-qiang FENG Jian-guo CAO | 2005 | Acta Pharmacologica Sinica2005，26，8： | 49 |
| 9 | Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury显示文摘关于人的脐的绳索考察最近的研究的目的间充质的干细胞(hUCMSCs ) 和在针的绳索损害的治疗的进展,数据来源关于 hUCMSCs 出版了文章(1983-2007 ) ,针的绳索损害用 Medline 被选择。选择的学习选择文章为在针的绳索损害治疗的移植与间充质的干细胞(MSC ) 的开发相关。258,原来, identifiied 产生 51 被选择那明确地探讨了说的目的。最近的工作揭示了的结果大多数有 MSC 的特征从骨头髓导出的那 hUCMSCs 份额并且对为房间的移植适当的更多被基于治疗。结论人的脐的绳索能为试验性、临床的需要被认为是 MSC 的来源。作为干细胞的古怪来源,另外, hUCMSCs 可以在针的绳索损害的处理起一个重要作用。 | CAO Fu-jiang FENG Shi-qing | 2009 | Chinese Medical Journal2009，，2： | 44 |
| 10 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 11 | Analysis on hidden blood loss of total knee arthroplasty in treating knee osteoarthritis显示文摘背景全部的膝关节造形术(TKA ) 是为各种各样的迟了阶段的膝疾病的治疗的重要治疗。然而,病人们有更低的血红素(HB ) ,这被观察了手术后地数,它与测量的血损失显著地不一致。尽管隐藏的血损失的概念在 2000 被介绍了,很,很少临床的注意从那以后都没被给予。在这研究,我们在对待膝 osteoarthritis.Methods 在 TKA 以后调查了特征和隐藏的血损失的有影响的因素与 42 男性和 66 女性一起, 108 个病人回顾地被分析。perioperative 血损失和隐藏的血损失追随者 TKA 被粗野公式计算。影响 perioperative 和隐藏的血损失的潜在的因素包括了性,外科的时间,止血带时间, hemostasis (在有降低的操作期间止血带) ,并且平均 perioperative 血损失被发现是的抢救 blood.Results 的注入(1553 吗?? | SHEN Hui-liang LI Zheng FENG Ming-li CAO Guang-le | 2011 | Chinese Medical Journal2011，，11： | 47 |
| 12 | Mechanism underlying treatment of ischemic stroke using acupuncture:transmission and regulation显示文摘The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair.After cerebral ischemia/reperfusion,microglia are activated,and a large number of circulating inflammatory cells infiltrate the affected area.This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage,including neuron necrosis,blood-brain barrier destruction,cerebral edema,and an oxidative stress response.Activation of inflammatory signaling pathways plays a key role in the pathological process of ischemic stroke.Increasing evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous system.Acupuncture can not only inhibit the activation and infiltration of inflammatory cells,but can also regulate the expression of inflammation-related cytokines,balance the effects of pro-inflammatory and anti-inflammatory factors,and interfere with inflammatory signaling pathways.Therefore,it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using acupuncture.Our review summarizes the overall conditions of inflammatory cells,mediators,and pathways after cerebral ischemia/reperfusion,and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration. | Bing-Qian Cao Feng Tan Jie Zhan Peng-Hui Lai | 2021 | Neural Regeneration Research2021，16，5： | 43 |
| 13 | Survey of information security显示文摘The 21st century is the age of information when information becomes an important strategic resource. The information obtaining, processing and security guarantee capability are playing critical roles in comprehensive national power, and information security is related to the national security and social stability. Therefore, we should take measures to ensure the information security of our country. In recent years, momentous accomplishments have been obtained with the rapid development of information security technology. There are extensive theories about information security and technology. However, due to the limitation of length, this article mainly focuses on the research and development of cryptology, trusted computing, security of network, and information hiding, etc. | SHEN ChangXiang ZHANG HuangGuo FENG DengGuo CAO ZhenFu HUANG JiWu | 2007 | Science in China(Series F)2007，50，3： | 39 |
| 14 | Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS显示文摘Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within China's Mainland is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both. | ZHOU ShanShi CAO YueLing ZHOU JianHua HU XiaoGong TANG ChengPan LIU Li GUO Rui HE Feng CHEN JunPing WU Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 31 |
| 15 | Direct transformation of FGD gypsum to calcium sulfate hemihydrate whiskers:Preparation,simulations,and process analysis显示文摘Calcium sulfate hemihydrate(CSH) whiskers were synthesized by phase transition in CaCl_2 solution under atmospheric pressure.Analytical-grade calcium sulfate dihydrate(AR CSD) was used as the raw material for the synthesis of CSH whiskers,according to orthogonal experiments.The effects of reaction temperature,AR CSD content,H_2SO_4 content,and reaction time were investigated,and the crystallization conditions were optimized.The as-prepared CSH whiskers displayed a regular morphology and a highly uniform size,with an aspect ratio of 105.A simulation system was also established by blending various sulfates with AR CSD,to evaluate the effects of impurities in flue gas desulfurization(FGD) gypsum.The main aim was to prepare CSH whiskers directly from FGD gypsum,without any purification,using the optimized conditions.This is a facile potential alternative process for large-scale production of CSH whiskers using abundant FGD gypsum as source materials. | Miao Miao Xin Feng Gangling Wang Shaomei Cao Wen Shi Liyi Shi | 2015 | Particuology2015，13，2： | 31 |
| 16 | Indocyanine green clearance test combined with MELD score in predicting the short-term prognosis of patients with acute liver failure显示文摘BACKGROUND: Acute liver failure(ALF) is an acute severe deterioration of liver function with high mortality. Early and accurate prognostic assessment of patients with ALF is critically important. Although the model for end-stage liver disease(MELD) scores and King's College Hospital(KCH) criteria are well-accepted as predictive tools, their accuracy is unsatisfactory.The indocyanine green(ICG) clearance test(ICGR15, ICG retention rate at the 15 minutes) is a sensitive indicator of liver function. In this study, we investigated the efficacy of the ICGR15 for the short-term prognosis in patients with ALF. We compared the predictive value of ICGR15 with the MELD scores and KCH criteria.METHODS: Sixty-nine patients who had been diagnosed with ALF were recruited retrospectively. ICGR15 had been performed by ICG pulse spectrophotometry and relevant clinical and laboratory indices were analyzed within 24 hours of diagnosis.In addition, the MELD scores and KCH criteria were calculated.RESULTS: The three-month mortality of all patients was 47.83%.Age, serum total bilirubin and creatinine concentrations,international normalized ratio for prothrombin time, ICGR15,MELD scores and KCH criteria differed significantly between surviving and deceased patients. A positive correlation was observed between ICGR15 and MELD scores(r=0.328, P=0.006).The ICGR15-MELD model, Logit(P)=0.096×ICGR15+0.174 ×MELD score–9.346, was constructed by logistic regression analysis. The area under the receiver operating characteristic curve was 0.855. When set the cut-off point to-0.4684, the sensitivity was 87.90% and specificity, 72.20%. The area under the receiver operating characteristic curve of the ICGR15-MELD model(0.855) was significantly higher than that of the ICGR15(0.793), MELD scores(0.776) and KCH criteria(0.659).Based on this cut-off value, the patients were divided into two groups. The mortality was 74.36% in the first group(ICGR15-MELD≥-0.4686) and 13.33% in the second group(ICGR15-MELD<-0.4686), with a significant difference between the two groups(χ2=25.307, P=0.000).CONCLUSION: The ICGR15-MELD model is superior to the ICGR15, MELD scores, and KCH criteria in predicting the shortterm prognosis of patients with ALF. | Hong-Ling Feng Qian Li Lin Wang Gui-Yu Yuan Wu-Kui Cao | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 27 |
| 17 | Monitoring Winter Wheat Freeze Injury Using Multi-Temporal MODIS Data显示文摘Freeze injury is an usual disaster for winter wheat in Shanxi Province, China, and monitoring freeze injury is of important economic significance. The aim of this article is to monitor and analyze the winter wheat freeze injury using remote sensing data, to monitor the occurrence and spatial distribution of winter wheat freeze in time, as well as the severity of the damage. The winter wheat freeze injury was monitored using multi-temporal moderate-resolution imaging spectroradiometer (MODIS) data, combined with ground meteorological data and field survey data, the change of normalized difference vegetation index (NDVI) before and after freeze injury was analyzed, as well as the effect of winter wheat growth recovery rate on yield. The results showed that the NDVI of winter wheat decreased dramatically after the suffering from freeze injury, which was the prominent feature for the winter wheat freeze injury monitoring. The degrees of winter wheat freeze injury were different in the three regions, of which, Yuncheng was the worst severity and the largest freeze injury area, the severity of freeze injury correlates with the breeding stage of the winter wheat. The yield of winter wheat showed positive correlation with its growth recovery rate (r = 0.659**) which can be utilized to monitor the severity of winter wheat freeze injury as well as its impact on yield. It can effectively monitor the occurrence and severity of winter wheat freeze injury using horizontal and vertical profile distribution and growth recovery rate, and provide a basis for monitoring the winter wheat freeze injury in Shanxi Province. | FENG Mei-chen YANG Wu-de CAO Liang-liang DING Guang-wei | 2009 | Agricultural Sciences in China2009，8，9： | 27 |
| 18 | Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement显示文摘AIM: To study the effects of magnolol and honokiol on isolated smooth muscle of gastrointestinal tract and their relationship with Ca2+, and on the gastric emptying and the intestinal propulsive activity in mice.METHODS: Routine experimental methods using isolated gastric fundus strips of rats and isolated ileum segments of guinea pigs were adopted to measure the smooth muscle tension. The effects of magnolol 10-3, 10-4, 10-5 mol/L, and honokiol 10-4, 10-5, 10-6 mol/L on the contractility of gastric fundus strips of rats and ileum of guinea pigs induced by acetylcholine (Ach) and 5-hydroxytryptamine (5-HT)was assessed respectively. The method using nuclein and pigment methylene blue was adopted to measure the gastric retention rate of nuclein and the intestinal propulsive ratio of a nutritional semi-solid meal for assessing the effect of magnolol and honokiol (0.5, 2, 20 mg/kg) on gastric emptying and intestinal propulsion.RESULTS: Magnolol and honokiol significantly inhibited the contractility of isolated gastric fundus strips of rats treated with Ach or 5-HT and isolated ileum guinea pigs treated with Ach or CaCl2, and both of them behaved as non-competitive muscarinic antagonists. Magnolol and honokiol inhibited the contraction induced by Ach in Ca2+-free medium and extracellular Ca2+-dependent contraction induced by Ach. Each group of magnolol and honokiol experiments significantly decreased the residual rate of nuclein in the stomach and increased the intestinal propulsive ratio in mice.CONCLUSION: The inhibitory effect of magnolol and honokiol on contractility of the smooth muscles of isolated gastric fundus strips of rats and isolated ileum of guinea pigs is associated with a calcium-antagonistic effect.Magnolol and honokiol can improve the gastric emptying of a semi-solid meal and intestinal propulsive activity in mice. | Wei-Wei Zhang Yan Li Xue-Qing Wang Feng Tian Hong Cao Min-Wei Wang Qi-Shi Sun | 2005 | World Journal of Gastroenterology2005，11，28： | 22 |
| 19 | Effect of Silver Content on Microstructure and Properties of Brass/steel Induction Brazing Joint Using Ag-Cu-Zn-Sn Filler Metal显示文摘The induction brazing of brass to steel using Ag-Cu-Zn-Sn filler metal was investigated in this study.The influence of Ag content on the microstructure and properties were analyzed by means of optical microscopy,scanning electron microscopy and electron probe microanalysis.Defect free joint was achieved using Ag-Cu-Zn-Sn filler metal.The microstructure of the joint was mainly composed of Ag-based solid solution and Cu-based solid solution.The increase of Ag content and the cooling rate both led to the increase of the needle like eutectic structure.The tensile strength decreased with the increase of Ag content.The tensile strength at room temperature using Ag25CuZnSn filler metal reached 445 MPa.All fractures using Ag-Cu-Zn-Sn filler metal presented ductile characteristic. | J. Cao L.X. Zhang H.Q. Wang L.Z. Wu J.C. Feng | 2011 | Journal of Materials Science & Technology2011，27，4： | 23 |
| 20 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
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