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12篇 您的检索式:作者名="Pole N"
    题名 作者 年代 出处 被引量
1Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this.Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi 2014World Journal of Gastroenterology2014,20,44:3
2Strengths of character and postt- raumatic growth 显示文摘Peterson C Park N Pole N 2008J Traumat Stress2008,21,2:1
3Electrophysiologic threshold study in air and bone conduction in children with 2 months or less age显示文摘Silvia Nápole Fichino Doris Ruthy Lewis Mariana Lopes Fávero 2007Brazilian Journal of Otorhinolaryngology2007,,2:1
4PTSD symptoms predict waking salivary cortisol levels in police officers 显示文摘Neylan T C Brunet A Pole N 2005Psychoneuroendocrinol- ogy2005,30,4:1
5The Role of Dithiolates in the Flotation of Sulfide Minerals显示文摘Finkestein N P Poling G W 1977Miner Sci Eng1977,9,4:1
6Gender and PTSD: What can we learn from female police officers?显示文摘Lilly MM Pole N Best SR 2009J Anxiety Disord2009,23,6:1
7Resilience in retired police officers 显示文摘Pole N Kulkami M 2006Trauma- tology2006,12,3:1
8Examination of the influence of leptin and acute metabolic challenge on RFRP-3 neurons of mice in development and adulthood显示文摘Poling MC Shieh MP Munaganuru N 2014Neuroendocrinology2014,100,4:1
9Psychiatric distress among Asian and European American survivors of the 1994 Northridge earthquake 显示文摘Kulkami M Pole N 2008J Nerv Merit Dis2008,196,8:1
10Strengths of character and posttraumatic growth显示文摘Peterson C Park N Pole N D'Andrea W & Seligman M.E.P 0,,02:1
11A simple radiological method for recognizing osteoporotic thoracic vertebral compression fractures and distinguishing them from Scheuermann disease 显示文摘Masharawi Y Rothschild B Poled N 2009Spine (Phila Pa 1976)2009,34,18:1
12Patient–physicians’ information exchange in outpatient cardiac care: Time for a heart to heart?显示文摘Urmimala Sarkar Dean Schillinger Kirsten Bibbins-Domingo Anna Nápoles Leah Karliner Eliseo J. Pérez-Stable 2010Patient Education and Counseling2010,,2:1
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