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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin 显示文摘 | Wirth J Poletti S Aeschlimann B | 2009 | Plant Biotechnol J2009，7，： | 1 |
| 3 | Should vein be saved for future operations?a 15-year review of infrainguinal bypasses and the subsequent need for autogenous vein显示文摘 | MATSUURA J H DATTILO J B | 1998 | Ann Vasc Surg1998，12，： | 1 |
| 4 | Bronchoalveolar lavage in ma- lignancy 显示文摘 | Poletti V Poletti G Muter B | 2007 | Semi Respir Crit Care Med2007，28，5： | 1 |
| 5 | Blunt abdominal frauma:should US be used to detect both free fluid and organ injures?显示文摘 | Poletti PA Kinkel K Verrdeulen B | 2003 | Radiology2003，227，1： | 1 |
| 6 | Relationship among parameters of lake polluted sediments evaluated by multivariate statistical analysis显示文摘 | Bartolomeo A De Poletti L Sanchini G Sebastiani B Morozzi G | 2004 | Chemosphere2004，55，： | 1 |
| 7 | Broncho-alveolar ]av- age in malignancy显示文摘 | Poletti V Poletti G Muter B | 2007 | Semin Respir Crit Care Med2007，28，5： | 1 |
| 8 | The emerging technique of the antiptosis subdermal suspension thread显示文摘 | Lycka B Bazan C Poletti E | 2004 | Dermatol Surg2004，30，1： | 1 |
| 9 | Blunt abdominal trauma:should US be used to detect both free fluid and organ injuries?显示文摘 | Poletti PA Kinkel K Vermeulen B | 2003 | Radiology2003，227，1： | 1 |
| 10 | Nutrients limiting the algal growth potential (AGP) in the Po River plume and an adjacent area, Northwest Adriatic Sea: Enrichment bioassays with the test algaeNitzschia closterium andThalassiosira pseudonana显示文摘 | Serge Y. Maestrini Brigitte R. Berland Martine Bréret Christian Béchemin Roberto Poletti Attilio Rinaldi | 1997 | Estuaries1997，，2： | 1 |
| 11 | Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin显示文摘 | Wirth J Poletti S Aeschlimann B | | 0，，07： | 1 |
| 12 | Broncho-alveolar lavage in malignancy 显示文摘 | Poletti V Poletti G Murer B | 2007 | Semin Respir Crit Care Med2007，28，5： | 1 |
| 13 | Broncho-alveolar lavage in malignancy 显示文摘 | Poletti V Poletti G Murer B | 2007 | Semin Respir C fit Care Med2007，28，5： | 1 |
| 14 | Blunt abdominal trauma:Should us be used to detect both free fluid and organ injuries显示文摘 | Kinkel K Vermeulen B | 2003 | Radiology2003，227，1： | 1 |
| 15 | The emerging technique of the antiptosis subdermal suspension thread显示文摘 | Lycka B Bazan C Poletti E | 2004 | Dennatol Surg2004，30，1： | 1 |
| 16 | Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin 显示文摘 | Wirth J Poletti S Aeschlimann B Yakandawala N Drosse B Osorio S Tohge T Fernie A R Gunther D Gruissem W Sautter C | 2009 | Plant Biotechnology Journal2009，7，7： | 1 |
| 17 | Blunt abdominal trauma: should US be used to detect both free fluid and organ injuries显示文摘 | Poletti PA Kinkel K Verrdeulen B | 2003 | Radiology April2003，227，1： | 1 |
| 18 | 查看详情显示文摘 | D Poletti C Miniatura B Grémaud | | 0，，03： | 1 |
| 19 | Bronchoalveolar lavage in malignancy 显示文摘 | Poletti V Poletti G Murer B | 2007 | Semin Respir Crit Care Med2007，28，5： | 1 |
| 20 | Blunt abdominal tra0ma: should US be used to detect both free fluid and organ injuries? 显示文摘 | Poletti PA Kinkel K Vermeulen B | 2003 | Radiology2003，227，1： | 1 |
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