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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Microporous polymeric composites from bicontinuous microemulsion polymerization using a polymerizable nonionic surfactant 显示文摘 | Gan L M Lin J Poon L P | 1997 | Polymer1997，38，： | 3 |
| 3 | Coronavirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peris J S M Lai S T Poon L L M | 2003 | Lancet2003，361，： | 2 |
| 4 | Coronavirus as a possible cause of severe respiratory syndrome显示文摘 | PERIS J S M LAI S T POON L L M | 2003 | Lancet2003，361，9366： | 2 |
| 5 | SARS study group:coro-navirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris J S Lai S T Poon L L | 2003 | Lancet2003，361，： | 2 |
| 6 | Mg-Ca-Zn bulk metallic glasses with high strength and significant ductility显示文摘 | GU X SHIFLET G J GUO F Q POON S J | 2005 | Journal of Materials Research2005，20，8： | 1 |
| 7 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells 显示文摘 | Hartigan-O' Connor D J Poon C Sinclair E | 2007 | J Immunol Methods2007，319，12： | 1 |
| 8 | Coronavirus as a possible cause of severe acute respiratory syndrome显示文摘 | Peiris J Lai S Poon L | 2003 | Lancet2003，361，9366： | 1 |
| 9 | Synthesis, Spectroscopic and Electrochemical Properties of Rare Earth Double - Deckers with Tetra(tert - butyl) - 2,3 -naphthalocyaninato Ligands 显示文摘 | J Jiang W Liu K- W Poon D Du D P Arnold DKPNg | 2000 | Euro J Inorg Chem2000，205，： | 1 |
| 10 | Ductile titanium-based glassy alloy ingots显示文摘 | GUO F WANG H J POON S J | 2005 | Appl Phy Lett2005，86，09： | 1 |
| 11 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain ( CD127 ), allowing consistent identification and sorting of live cells显示文摘 | Hartigan-O'Connor DJ Poon C Sinclair EDennis J | 2007 | J Immunol Methods2007，319，12： | 1 |
| 12 | Adhesion of statistical andblocky ethylene-octene polypropylene显示文摘 | Dias P J Lin Y Poon B | 2008 | Polymer2008，49，： | 1 |
| 13 | Provision of continuous VCR functions in interactive broadcast VoD systems 显示文摘 | POON W F LOK T FENG J | 2005 | IEEE Transition Broadcasting2005，51，4： | 1 |
| 14 | Adaptive Batching Scheme for Multicast Video-on-demand Systems显示文摘 | POON W E LO K T FENG J | 2001 | IEEE Transactions on Broadcasting2001，47，1： | 1 |
| 15 | Coronavirus as a possible cause of severe acute respiratory syndrome 显示文摘 | Peiris J S M Lai S T Poon L L M | 2003 | Lancet2003，361，： | 1 |
| 16 | Towards a Regional Strategy:the Role of Regional Headquarters of Foreign Firms in Singapore显示文摘 | Yeung H Poon J Perry M | 2001 | Urban Studies2001，38，： | 1 |
| 17 | 2010, Reassort- ment of pandemic H1N1/2009 influenza A virus in swine 显示文摘 | Vijaykrishna D Poon L L Zhu H C Ma S K Li 0 T Che- unq C L Smith G J Peiris J S Guan Y | 2010 | Science2010，328，5985： | 1 |
| 18 | Combustion smoke exposureinduces up-regulated expression of vascular endothelialgrowth factor,aquaporin 4,nitric oxide synthases and vascularpermeability in the retina of adult rats 显示文摘 | Zou YY Lu J Poon DJ | 2009 | Neuroscience2009，160，3： | 1 |
| 19 | Ampakines alleviate respiratory depression in rats 显示文摘 | REN J POON B Y TANG Y | 2006 | Am J Resp Crit Care Med2006，174，12： | 1 |
| 20 | Influence of perfor- mance evaluation rating segme-ntation on motivation and fairness perceptions 显示文摘 | Bartol K M Durham C C Poon J M L | 2001 | Joumal of Applied Psychology2001，86，6： | 1 |
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