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| 1 | Proposed case of mesalazine-induced cardiomyopathy in severe ulcerative colitis显示文摘Five-amino salicylic acids are recommended for use in the management of inflammatory bowel disease,cardiac complications are a rare although recognised phenomenon.This report aims to highlight this serious but rare adverse reaction.We report here a case of a young man presenting with cardiogenic shock in the context of recent mesalazine treatment in severe ulcerative colitis. | Kathryn Fleming Andrew Ashcroft Christopher Alexakis Demitrios Tzias Christopher Groves Andrew Poullis | 2015 | World Journal of Gastroenterology2015，21，11： | 9 |
| 2 | Emerging role of novel biomarkers in the diagnosis of inflammatory bowel disease显示文摘There is currently no gold standard test for the diagnosis of inflammatory bowel disease(IBD). Physicians must rely on a number of diagnostic tools including clinical and endoscopic evaluation as well as histologic, serologic and radiologic assessment. The real difficulty for physicians in both primary and secondary care is differentiating between patients suffering from functional symptoms and those with true underlying IBD. Alongside this, there is always concern regarding the possibility of a missed, or delayed diagnosis of ulcerative colitis(UC) or Crohn's disease. Even once the diagnosis of IBD has been made, there is often uncertainty in distinguishing between cases of UC or Crohn's. As a consequence, in cases of incorrect diagnosis, optimal treatment and management may be adversely affected. Endoscopic evaluation can be uncomfortable and inconvenient for patients. It carries significant risks including perforation and in terms of monetary cost, is expensive. The use of biomarkers to help in the diagnosis and differentiation of IBD has been increasing over time. However, there is not yet one biomarker, which is sensitive of specific enough to be used alone in diagnosing IBD. Current serum testing includes C-reactive protein and erythrocyte sedimentation rate, which are cheap, reliable but non-specific and thus not ideal. Stool based testing such as faecal calprotectin is a much more specific tool and is currently in widespread clinical use. Noninvasive sampling is of the greatest clinical value and with the recent advances in metabolomics, genetics and proteomics, there are now more tools available to develop sensitive and specific biomarkers to diagnose and differentiate between IBD. Many of these new advances are only in early stages of development but show great promise for future clinical use. | Anet A Soubières Andrew Poullis | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 6 |
| 3 | Challenges in the management of pancreatic exocrine insufficiency显示文摘Pancreatic exocrine insufficiency(PEI) occurs when the insufficient secretion or function of pancreatic enzymes leads to maldigestion, most commonly as a result of chronic pancreatitis and pancreatic cancer. The condition is associated with significant morbidity and reductions in quality of life, even in milder forms. The challenges in approaching this condition include the non-specific presentation of mild to moderate PEI, and the lack of a convenient, accurate diagnostic test in this cohort. Classical symptoms appear late in the disease, and the diagnosis should be considered before steatorrhoea develops. Direct pancreatic function tests are the reference standard for diagnosis, but are invasive and not widely available. The faecal elastase-1(FE-1) stool test is widely available and has been shown to be as effective as the 13 C-mixed triglyceride breath test in more advanced disease. We recommend a pragmatic diagnostic approach that combines clinical history, assessment of nutritional status and measurement of FE-1. The critical first step is to consider the diagnosis. Once the diagnosis is confirmed, pancreatic enzyme replacement therapy should be initiated. The variety of enzyme preparations and recommended dosing regimens can present a challenge when selecting an adequate initial dose. Non-response should be actively sought and addressed in a systematic manner. This article discusses these challenges, and presents a practical approach to the diagnosis and management of PEI. | Benjamin Myles Shandro Rani Nagarajah Andrew Poullis | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，5： | 5 |
| 4 | Proton pump inhibitors are associated w ith evaluat ion of faecal calprotectin and may affect specif icity 显示文摘 | Poullis A Foster R Mendall MA | 2003 | Eur J Gastroenterol Hepatol2003，15，5： | 1 |
| 5 | Synchronous fluores- cence spectroscopy for quantitative determination of virgin ol- ive oil adulteration with sunflower oil 显示文摘 | Poulli K I Mousdis G A Georgiou C A | 2006 | Analytical and Bioanalytical Chemistry2006，386，： | 1 |
| 6 | The antithrombotic effect of aprotinin:actions mediated via the protease-activated receptorl显示文摘 | Manning R Laffan M | 2000 | J Thorac Cardiovasc Surg2000，120，： | 1 |
| 7 | The antithrombotic and antiinflammatory mechanisms of action of aprotinin 显示文摘 | Asimakopoulos G Poullis M | 2001 | Ann Thorac Surg2001，72，6： | 1 |
| 8 | Catastrophic cardiovascular adverse reactions to protamine 显示文摘 | Poullis M Shackcloth M | 2003 | Chest2003，124，1： | 1 |
| 9 | The antithrombotic effect of aprotinin:actions mediated via the proteaseactivated receptor 1显示文摘 | Manning R Laffan M | 2000 | J Thorac Cardiovasc Surg2000，120，2： | 1 |
| 10 | Effect of aprotinin(trasylol) on the inflammatory and thrombotic complications of conventional cardiopulmonary bypass surgery显示文摘 | Landis RC Asimakopoulos G Poullis M | 2001 | Heart Surg Forum2001，，： | 1 |
| 11 | Biliptysis caused by a bronchobiliary fistula显示文摘 | Poullis M Poullis A | 1999 | J Thorac Cardiovasc Surg1999，118，： | 1 |
| 12 | The antithrombotic and antiinflammatory mechanisms of action of aprotinin显示文摘 | Asimakopoulos G Poullis M | 2001 | Ann Thorac Surg2001，72，6： | 1 |
| 13 | A new highly sensitive assay for Creactive protein can aid the differentiation of inflammatory bowel disorders from constipation and diarrhea-predominant functional bowel disorders显示文摘 | Poullis AP Zar S Sundaram KK etal | 2002 | Eur J Gastroenterol Hepatol2002，14，4： | 1 |
| 14 | A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammato- ry bowel disorders from constipation- and diarrhea-predominant functional bowel disorders显示文摘 | Poullis AP Zar S Sundaram KK | 2002 | Eur J Gastroenterol Hepatol2002，14，4： | 1 |
| 15 | Temporal trends in imaging and associated radiation exposure in inflammatory bowel disease 显示文摘 | Chatu S Poullis A Holmes R | 2013 | Int J Clin Pract2013，67，： | 1 |
| 16 | Rapid synchronous fluorescence method for virgin olive oil adulteration assessment 显示文摘 | Konstantina I Poulli George A Mousdis Constantinos A Georgiou | 2007 | Food Chemistry2007，105，： | 1 |
| 17 | Photorealistic large-scale urban city model reconstruction显示文摘 | Poullis C You S | 2009 | IEEE Transactions on Visualization and Computer Graphics2009，15，4： | 1 |
| 18 | Rapid synchronous fluorescence method for virgin olive oil adul- teration assessment 显示文摘 | POULLI K I MOUSDIS G A GEORGIOU C A | 2007 | Food Chem2007，105，1： | 1 |
| 19 | A framework for automatic modeling from point cloud data显示文摘 | Poullis C | 2013 | IEEE Pattern Analysis and Machine Intelligence2013，35，11： | 1 |
| 20 | Fusarium wilt of watermelon in Cyprus and its management with soil solarization combined with fumigation or ammonium fertilizers显示文摘 | Ioannou N Poullis C A Heale J B | 2000 | Bulletin OEPP2000，30，2： | 1 |
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