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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Comparison of protein of ADP-glucose pyrophorylase from diverse显示文摘 | SMITH WHITE B J PREISS J | 1992 | J Mol Evol1992，34，： | 1 |
| 3 | Geosynchronous space based radar concept development for theater surveillance显示文摘 | Fiedler S Preiss B | 1996 | IEEE Aerospace Applications Conference1996，，2： | 1 |
| 4 | Comparison of proteias of ADP-glucose pyrophosphorylase from diverse sources显示文摘 | Smith-White B Preiss J | | 0，，： | 1 |
| 5 | Cholesterol and coronary heart disease:predicting risks by levels and ratios显示文摘 | Kinosian B Glick H Preiss L | 1995 | J Investig Med1995，43，5： | 1 |
| 6 | Preparation of molybdenum and tungsten carbides from solution derived precursors显示文摘 | Preiss H Meyer B Olschewski C | 1998 | Journal of Materials Science1998，33，3： | 1 |
| 7 | Test Performance Characteristics of Anti HEVlgG Assays Strongly Influence Hepatitis E Seropreva- lence Estimates显示文摘 | Wenzel J J Preiss J Schemmerer M Huber B Jilg W | 2013 | Journal of Infectious Diseases2013，207，3： | 1 |
| 8 | ADP-glucose pyrophosphorylase,a regulatory enzyme for bacterial glycogen synthesis显示文摘 | Miguel A B Iglesias A A Preiss J | 2003 | Microbiology and Molecular Biology Reviews2003，67，： | 1 |
| 9 | ADPglucose pyrophosphorylase from the CAM,plants,xoya carnosa and Xerosicyos danguyi显示文摘 | SINGH B K GREENBERG E PREISS J | 1984 | Plant Physiology1984，74，： | 1 |
| 10 | Mortgage Lending Discrimination and The Decision to Apply:A Methodological Note显示文摘 | BLOOM D E PREISS B TRUSSELL J | 1983 | Real Estate Economics1983，11，1： | 1 |
| 11 | Critical role for classical PKC in activating Akt by phospholipase A2 modified LDL in monocytic cells显示文摘 | Preiss S Namgaladze D Brune B | 2007 | Cardiovasc Res2007，73，： | 1 |
| 12 | Pi:A practical incentive protocol for delay tolerant networks显示文摘 | Lu R Lin X Zhu H Shen X and Preiss B | 2010 | IEEE Trans on Wireless Communications2010，9，14： | 1 |
| 13 | The major proteins of wheat endosperm starch granules显示文摘 | Rahman S Kosar-Hashemi B Samuel M S Hill A Abbott D C Skerritt J H Preiss J Appels R M | | 0，，： | 1 |
| 14 | Comparison of proteins of ADP-glucose pyrophosphorylase from diverse sources显示文摘 | SMITH-WHITE B J PREISS J | 1992 | Journal of Molecular Evolution1992，34，5： | 1 |
| 15 | Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios 显示文摘 | Kinosian B Gliek H Preiss L | 1995 | J Investig Med1995，43，5： | 1 |
| 16 | Molecular genetics of Kruppel,a gene required for segmentation of the Drosophi- la embryo显示文摘 | Preiss A Rosenberg U B Kienlin A | 1985 | Nature1985，313，5997： | 1 |
| 17 | ADP-glucose pyrophosphorylase from maize endospcrm显示文摘 | Dickinson D B Preiss J | 1969 | Archives Biochemistry and Biophysics1969，130，： | 1 |
| 18 | Starch biosynthesis and its regulation 显示文摘 | Preiss J Ball K Smith White B | 1991 | Biochemical Society Transactions1991，19，： | 1 |
| 19 | Presence of ADP glucose pyro phosphorylase in shrunken 2 and brittle-2 mutants of maize endosperm 显示文摘 | Dickinson David B Preiss Jack | 1969 | Plant Physiol1969，44，： | 1 |
| 20 | The Notch signaling path-way is required for Enhancer of split bHLH protein expression dur-ing neurogenesis in the Drosophila embryo显示文摘 | Jennings B Preiss A Delidakis C | 1994 | Development1994，120，12： | 1 |
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