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| 1 | Cholangiocyte anion exchange and biliary bicarbonate excretion显示文摘主要小管胆汁沿着被几个因素包括荷尔蒙, innervation/neuropeptides,和胆汁的成分影响的胆道经历使液化和硷化的一个过程。在 canaliculi 和胆汁管的酸式碳酸盐的排泄是到所谓的胆汁盐独立人士流动的产生的一个重要贡献者。酸式碳酸盐通过经由 AE2/SLC4A2-mediated Cl-/HCO3- 交换通过 Cl- 隧道,和进一步的酸式碳酸盐分泌物的激活包含氯化物流出的平行机制从 hepatocytes 和 cholangiocytes 被分泌。高血糖素和分泌素是似乎在他们的目标房间(为前者的 hepatocytes 和为后者的 cholangiocytes ) 很同样行动的二相关荷尔蒙。这些荷尔蒙与他们的特定的 G 联合蛋白质的受体交往,引起营地的细胞内部的层次和营地依赖者 Cl- 和 HCO3- 的激活的增加能分泌的机制。hepatocytes 和 cholangiocytes 看起来有在的营地应答的细胞内部的泡有房间 specific Cl- 隧道的 AE2/SLC4A2 colocalizes (在 cholangiocytes 并且还没的 CFTR 在 hepatocytes 决定了) 并且 aquaporins (在 hepatocytes 的 AQP8 和在 cholangiocytes 的 AQP1 ) 。到小管或 cholangiocyte lumenal 膜和进一步的 exocytosis 的这些泡的导致营地的协调交通国王与网导致水的增加的渗透的力量和被运动充满酸式碳酸盐的胆液排泄增多。 | Jesús M Banales Jesús Prieto Juan F Medina | 2006 | World Journal of Gastroenterology2006，12，22： | 10 |
| 2 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 3 | Reversible and athermal photo-vitrification of As50 ·Se50 thin films deposited onto silicon wafer and glass substrates 显示文摘 | PRIETO - ALCON R MARQUEZ E GONZALEZ- LEAL J M | 1999 | Appl Phys A1999，68，： | 2 |
| 4 | Purification and characterization of a ealicivirus as the causative agent of a lethal hemorrhagic disease in rabbits显示文摘 | Parra F Prieto M | 1990 | J Virol1990，64，8： | 2 |
| 5 | Adherence to Lamivudine after an early withdrawal of hepatitis B immune globulin plays an important role in the long-term prevention of hepatitis B virus recurrence 显示文摘 | Buti M Mas A Prieto M | 2007 | Transplantation2007，84，5： | 1 |
| 6 | Comparison of pathogenic and spoilage bacterial levels on refrigerated poultry parts following treatment with trisodium phosphate 显示文摘 | DEL RIO E CAPITA R PRIETO M | 2006 | Food Microbiology2006，23，2： | 1 |
| 7 | Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes 显示文摘 | Guillen J de Ahneida RF Prieto M | 2009 | Mol Membr Biol2009，26，4： | 1 |
| 8 | Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients显示文摘 | Berenguer M Prieto M San JF | 2002 | Hepatology2002，36，1： | 1 |
| 9 | Building dynamic capabilities in product de- velopment: How do contextual antecedents matter? 显示文摘 | Isabel M Prieto Elena Revilla Beatriz Rodr?' guez- Prado | 2009 | Scandinavian Journal of Management2009，25，： | 1 |
| 10 | Environmental efficiency and regulatory standards:the case of CO2 emissions from OECD industries显示文摘 | ZOFIO J L PRIETO A M | 2001 | Resource and Energy Economics2001，23，1： | 1 |
| 11 | CTLA-4control over Foxp3 ( + ) regulatory T cell function 显示文摘 | WINGK ONISHI Y PRIETO - M ARTIN P | 2008 | Science2008，322，5899： | 1 |
| 12 | Evaluation of the Treponema pallidu m particl agglutination technique(TPPA)in the diagnosis of neurosyphilis显示文摘 | Castro R Prieto ESJoao Aguas M | 2006 | J Clin Lab Anal2006，20，6： | 1 |
| 13 | The phytotoxic activity of some metabolites of Botrytis cinerea 显示文摘 | Rebordinos L Cantoral J M Prieto M V | 1996 | Phytochemistry1996，42，： | 1 |
| 14 | Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes显示文摘 | Menet V Prieto M Privat A | 2003 | Proc Natl Acad Sci USA2003，100，15： | 1 |
| 15 | Endoglin haploinsufficien-cy promotes fibroblast accumulation during wound healing throughAkt activation 显示文摘 | Pericacho M Velasco S Prieto M | 2013 | PLOS ONE2013，8，54： | 1 |
| 16 | Purification and characterization of a caliclvirus as the causative agent of a lethal hemorrhagic disease in rabbits显示文摘 | Parra F Prieto M | 1990 | J Virot1990，64，： | 1 |
| 17 | Lichen planus-like keratosis: A clinical and histological reexamination显示文摘 | Prieto VG Casal M McNutt NS | 1993 | Am J Surg Pathol1993，17，3： | 1 |
| 18 | Statistical evaluation of mathematical models for microbial growth Intematonal显示文摘 | S Lopez M prieto J Dijkstra | 2004 | Jourmal of Food Microbiology2004，96，： | 1 |
| 19 | Dynamic Capabilities and the Role of Organizational Knowledge: An Exploration 显示文摘 | Prieto I M Easterby - Smith M | 2006 | European Journal of Information Systems2006，15，5： | 1 |
| 20 | Somatosensory evoked potential elicited by acupoint' s stimulus显示文摘 | AbadL Alegria F Melendo JA Prieto M | 1995 | Clin Electroencepha logr1995，26，： | 1 |
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