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| 1 | Effect of Yupingfeng Polysaccharide on Serum IL-2 and IFN-γ Levels in Immunosuppressive Mice显示文摘[Objective] The paper was to discuss regulation and protection effect of Yupingfeng polysaccharide( YPF-P) on immunosuppressive mice. [Method]Taking immunosuppressive mice induced by 80 mg / kg cyclophosphamide as test animal model,effects of different doses( 100,200 and 400 mg / kg) of YPF-P on spleen index,serum IL-2 and IFN-γ levels of mice were studied. [Result] High dose of YPF-P( 400 mg / kg) could improve the spleen index of immunosuppressive mice( P < 0. 05). YPF-P could enhance serum IL-2 and IFN-γ levels of immunosuppressive mice,and the effects in middle-dose group and low-dose group were better. YPF-P could significantly increase serum IL-2 level of normal mice( P < 0. 01),but it had no significant effect on serum IFN-γ level of normal mice.[Conclusion]The research provides an experimental basis for clinical application of YPF-P. | Yang Hong Deng Hua Lu Yuemei Li Minshen Pu Wenjun | 2015 | Animal Husbandry and Feed Science2015，7，2： | 1 |
| 2 | Inhibitory effect of procyanidin B2 and tannin acid on cholesterol esterase and their synergistic effect with orlistat显示文摘This study was aimed to analyze the effect of procyanidin B2(PC)and tannin acid(TA)on the activities of cholesterol esterase(CEase)and the inhibitory mechanisms of enzymatic activity.The interaction mechanisms were investigated by enzymatic kinetics,multi-spectroscopy methods,thermodynamics analysis,molecular docking,and dynamic simulations.PC and TA could bind with CEase and inhibit the activity of enzyme in a mixed-competitive manner and non-competitive manner,which was verified by molecular docking simulations and dynamics simulations.Also,PC and TA showed the synergistic inhibition with orlistat.Fluorescence,UVvis and the thermodynamic analysis revealed that the complexes were formed from CEase and inhibitors by noncovalent interaction.As revealed by the circular dichroism results,both PC and TA decreased enzymatic activities by altering the conformations of CEase.The inhibition of PC and TA on CEase might be one mechanism for its cholesterol-lowering effect. | Xiangxin Li Yijing Pu Haitao Jiang Wenxiao Jiao Wenjun Peng Wenli Tian Weibo Jiang Xiaoming Fang | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 3 | Biochemistry and transcriptome analysis reveal condensed tannins alleviate liver injury induced by regulating cholesterol metabolism pathway显示文摘Free cholesterol has been considered to be a critical risk factor of nonalcoholic fatty liver disease(NAFLD).It remains unknown whether dietary intake of condensed tannins(CTs)have distinguishable effects to alleviate liver damage caused by a high cholesterol diet.Male C57BL/6 mice were fed a high cholesterol diet for 6 weeks,and given CTs treatment at a dosage of 200 mg/(kg·day)at the same time.The results indicated that compared with mice fed a normal diet,a high cholesterol diet group resulted in significant weight loss,dysregulation of lipid metabolism in blood and liver,and oxidative stress in the liver,but CTs treatment dramatically reversed these negative effects.Hematoxylin and eosin(H&E)staining and frozen section observation manifested that CTs treatment could effectively reduce the deposition of liver cholesterol and tissue necrosis caused by high cholesterol intake.CTs alleviated liver injury mainly by regulating the expression of related genes in cholesterol metabolism pathway and AMPK phosphorylation.Our results confirmed that CTs have remarkable cholesterol lowering and anti-liver injury effects in vivo. | Xiangxin Li Yijing Pu Bangdi Liu Xiaoming Fang Wenjun Peng Weibo Jiang Wenli Tian | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
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