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| 1 | Nerve growth factor involvement in liver cirrhosis and hepatocellular carcinoma显示文摘AIM: To define NGF (nerve growth factor) and its high- affinity receptor trkANGF presence and distribution in fibrotic liver and in HCC, and to verify if NGF might have a role in fibrosis and HCC. METHODS: Intracellular distribution of NGF and trkANGF were assessed by immunohistochemistry and immuno- electron microscopy in liver specimens from HCC, cirrhosis or both. ELISA was used to measure circulating NGF levels. RESULTS: NGF and trkANGF were highly expressed in HCC tissue, mainly localized in hepatocytes, endothelial and some Kupffer cells. In the cirrhotic part of the liver they were also markedly expressed in bile ducts epithelial and spindle-shaped cells. Surprisingly, in cirrhotic tissue from patients without HCC, both NGF and trkANGF were negative. NGF serum levels in cirrhotic and/or HCC patient were up to 25-fold higher than in controls. CONCLUSION: NGF was only detected in liver tissue with HCC present. Intracellular distribution suggests paracrine and autocrine mechanisms of action. Better definition of mechanisms may allow for therapeutic and diagnostic/prognostic use of NGF. | Guido Rasi Annalucia Serafino Lia Bellis Maria Teresa Lonardo Federica Andreola Manuela Zonfrillo Giovanni Vennarecci Pasquale Pierimarchi Paola Sinibaldi Vallebona Giuseppe Maria Ettorre Eugenio Santoro Claudio Puoti | 2007 | World Journal of Gastroenterology2007，13，37： | 13 |
| 2 | Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection显示文摘 | Nezam Afdhal Stefan Zeuzem Paul Kwo Mario Chojkier Norman Gitlin Massimo Puoti Manuel Romero-Gomez Jean-Pierre Zarski Kosh Agarwal Peter Buggisch Graham R. Foster Norbert Br?u Maria Buti Ira M. Jacobson G. Mani Subramanian Xiao Ding Hongmei Mo Jenny C. Ya | 2014 | The New England Journal of Medicine2014，，： | 6 |
| 3 | Rapid clearance of HCV-related splenic marginal zone lymphoma under an interferon-free, NS3/NS4A inhibitor-based treatment. A case report显示文摘 | Roberto Rossotti Giovanna Travi Annamaria Pazzi Chiara Baiguera Enrica Morra Massimo Puoti | 2014 | Journal of Hepatology2014，，： | 2 |
| 4 | Histological and virological features and follow-up of hepatitis C virus carriers with normal aminotransferase levels: the Italian prospective study of the asymptomatic C carriers (ISACC) 显示文摘 | Puoti C CastelIacci R Montagnese F | 2002 | J Hepatol2002，37，1： | 1 |
| 5 | Diagnosis, management and treatment of hepatitis C显示文摘 | Puoti C Guarisco R Bellis L | 2009 | Hepatology2009，50，1： | 1 |
| 6 | Clinical,histological,and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels显示文摘 | Puoti C Magrini A Stati T | 1997 | Hepatology1997，26，6： | 1 |
| 7 | Preconditioning method for low-speed flows显示文摘 | Puoti V | 2003 | AIAA Journal2003，41，5： | 1 |
| 8 | A comparison of tau and 14-3- 3 protein in the diagnosis of Creutzfeldt-Jakob disease 显示文摘 | Hamlin C Puoti G Berri S | 2012 | Neurology2012，79，6： | 1 |
| 9 | Severe hepatotoxicity during combination antiretroviral treatment:incidence,liver histology,and outcome显示文摘 | Puoti M Torti C Ripamonti D the HIV-HCV Co-infection Study Group | 2003 | J Acquir Immune Defic Syndr2003，32，： | 1 |
| 10 | A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma 显示文摘 | Donato F Boffetta P Puoti M | 1998 | Int J Cancer1998，75，3： | 1 |
| 11 | Liver Fibrosis Progressioh Is Relatedto CD4Cell Depletion in Patient Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus显示文摘 | Massimo Puoti Maurizio Bonacini | 2001 | J Infect Dis2001，183，： | 1 |
| 12 | Hepatocel-lular carcinoma in HIV hepatitis C virus显示文摘 | Puoti M Rossotti R Garlaschelli A | 2011 | Curt()pin HIV AIDS2011，6，6： | 1 |
| 13 | Sex Determination in the Caenorhabditis elegans Germline 显示文摘 | Simone Zanetti Alessandro Puoti | 2013 | Advances in Experimental Medicine and Biology2013，757，： | 1 |
| 14 | Hepatitis C in patients with human immunodeficiency virus infection: diagnosis, natural history,meta-analysis of sexual and vertical transmission, and therapeutic issues 显示文摘 | Bonacini M Puoti M | 2000 | Arch Intern Med2000，160，22： | 1 |
| 15 | Prophylaxis and treatment of hepatitis B in immunocompromised patients显示文摘 | A. Marzano E. Angelucci P. Andreone M. Brunetto R. Bruno P. Burra P. Caraceni B. Daniele V. Di Marco F. Fabrizi S. Fagiuoli P. Grossi P. Lampertico R. Meliconi A. Mangia M. Puoti G. Raimondo A. Smedile | 2006 | Digestive and Liver Disease2006，，5： | 1 |
| 16 | Diagnosis, management, and treatment of hepatitis C 显示文摘 | Puoti C Guarisco R Bellis L | 2009 | Hepatology2009，50，1： | 1 |
| 17 | Diagnosis, manage- men, and treatment of hepatitis C显示文摘 | Puoti C Guarisco R Bellis L | 2009 | Hepatology2009，50，1： | 1 |
| 18 | Care of HIV patients with chronic hepatitis B: updated recommendations from the HIV-Hepatitis B Virus International Panel显示文摘 | Soriano V Puoti M Peters M et ol | 2008 | AIDS2008，22，12： | 1 |
| 19 | Care of patients with Hepatitis C and HIV co-infection显示文摘 | Soriano V Puoti M Sulkowski M | 2004 | AIDS2004，18，1： | 1 |
| 20 | Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus HIV显示文摘 | PUOTI M BONACINI M SPINETTI A | 2001 | J Infect Dis2001，183，1： | 1 |
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