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| 1 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 2 | Dynamic behavior of gas bubble in single bubble sonoluminescence—vibrator model显示文摘Single bubble sonoluminescence is a process of energy transformation from sound to light. Therefore the motion equations of near spherical vibration of a gas bubble in an incompressible and viscous liquid can be deduced by Lagrangian Equation with dissipation function when the bubble is considered as a vibrator surrounded by liquid. The analytical solutions in the bubble expanding, collapsing and rebounding stages can be obtained by solving these motion equations when some approximations are adopted. And the dynamic behaviors of the bubble in these three stages are discussed. | QIAN Menglu CHENG Qian GE Caoyan(Institute of Acoustics, Tongji University Shanghai 200092) Received Feb. 24, 2002 | 2002 | Chinese Journal of Acoustics2002，21，4： | 4 |
| 3 | The thermoelastic excitation of air-solid interface waves using the pulsed laser显示文摘Applying the integral transform to the coupled problem of thermoelastic and heat conduction equations, the integral representation of the normal displacement field for the air-solid interface waves excited by a pulsed laser line source is obtained. The pole residues of the integrand are performed analytically, and the transient displacement field is calculated by using FFT technique. The thermoelastic excitation and detection of the air-solid interface waves is carried out by a laser ultrasonic system, on which the pulsed laser is focused into a line source onto the interface to excite the air-solid interface waves: leaky Rayleigh wave and Scholte wave, and the interface waves displacement signal is detected successfully by a SH130 laser heterodyne interferometer. The theoretic and experimental results are in good agreement. | HU Wenxiang QIAN Menglu | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，2： | 4 |
| 4 | Ultrasonic displacement field generated by laser pulse line source显示文摘Applying the Fourier transform to the wave equations of elastic medium at its surface a laser pulse line source is acted, the integral representations of solutions are obtained. Displacement waveforms are calculated numerically by using double FFT. The calculated results include the displacements of the elastic half space of Aluminum medium, and epicenter and off-epicenter of an Aluminum plate. The two exciting sources of thermoelastic and ablating generation are considered respectively. The experiment was made on the Aluminum medium with a Nd:YAG laser and the normal displacement signals are detected by a laser interferometer. The numerical results are quite in agreement with experiments. | HU Wenxiang QIAN Menglu (Institute of Acoustics, Tongji University Shanghai 200092) | 2000 | Chinese Journal of Acoustics2000，19，2： | 4 |
| 5 | Analysis of Laser-generated Rayleigh wave on viscoelastic materials显示文摘以便理解材料的粘弹性,这研究被进行了理论上学习粘弹性的瑞利波浪的繁殖特征。一个模型在粘弹性的中等表面上为超声的搏动的激光产生被介绍。指了凯尔文模型,频率方程和粘弹性的瑞利的正常排水量波浪被导出,分散和变细上的粘弹性的模量的影响被讨论。从理论计算,瑞利波浪的变细上的粘弹性的效果在它的分散上多于那,这被显示出。在弱粘性的情况中,粘弹性的瑞利波浪的变细与粘性模量直接成正比;效果砍变细上的粘性是多于体积粘性的大部分。粘弹性的瑞利波浪的短暂反应也用 Laplace 和 Hankel 倒置变换被模仿,它在对理论上的预言的好同意被显示出。模型为媒介的粘弹性的参数的决心提供一个有用工具。 | HAN Qingbang QIAN Menglu | 2008 | Chinese Journal of Acoustics2008，27，1： | 3 |
| 6 | Measurement of acoustic field radiated by low frequency power ultrasonic transducer with laser-interferometer显示文摘Based on the piezo-optic effect of medium, the refractive index of medium is the function of its density, and so it’s also the function of acoustic pressure. Therefore, acoustic pressure in the optical path everywhere can be determined absolutely by laser-interferometric technique and relative distribution of pressure in the middle and far acoustic field, which can be obtained from theory or experiment respectively. Theory and experiment of measurement of pressure in acoustic field with laser-interferometer are introduced. Distribution of pressure radiated by a power ultrasonic transducer is determined by laser interferometric technique. The theoretical and experimental results are in good agreement. The receiving sensitivity of a PVDF (Polyvinylidene fluoride) transducer in free field is also calibrated absolutely due to above results and its sensitivity is -118.5 dB. | QIAN Menglu GAO Wen HU Wenxiang (Institute of Acoustics, Tongji University Shanghai 200092) | 2000 | Chinese Journal of Acoustics2000，19，4： | 2 |
| 7 | The technique of detecting the laser-ultrasonic vector displacement with a confocal Fabry-Perot interferometer waves in a plate显示文摘Generally,a confocal Fabry-Perot interferometer is only able to detect the out-of-plane component of a displhacement field;while the in-plane component often has the information about the material which cannot be found in this out-of-plane component.In this paper,based on a confocal Fabry-Perot interferometer set-up for detecting the out-of-plane component of a laser generated acoustic field.,a technique is developed to detect both the out-of-plane and inplane displacement components simultaneously with a novel two-channel confocal Fabry-perot interferometer. | PAN Yongdong QIAN Menglu(Institute of Acoustics, Tongji University Shanghai 200092) | 2003 | Chinese Journal of Acoustics2003，22，1： | 1 |
| 8 | Leaky Interface Wave Measurement at a Solid Solid Interface with Laser Ultrasonics 显示文摘 | WANG Hao HAN Qingbang QIAN Menglu | 2012 | Chin Phys Lett2012，29，10： | 1 |
| 9 | Dispersive properties of cylindrical Rayleigh waves显示文摘 | WU Xianmei QIAN Menglu CANTRELL J H | 2003 | Applied Physics Letters2003，83，9： | 1 |
| 10 | Theoretical and experimental investigation of imaging the acoustic fields by Schlieren techniques显示文摘 | JIANG Xueping CHENG Qing QIAN Menglu | 2011 | Technical Acoustics2011，30，5： | 1 |
| 11 | Visualization of point-focusing ultrasonic field by three-dimensional Schlieren method显示文摘 | XU Zheng CHEN Hao QIAN Menglu | 2014 | Technical Acoustics2014，33，2： | 1 |
| 12 | The thermoelastic excitation of air-solid interface waves using the pulsed laser显示文摘 | Wenxiang Hu Menglu Qian | 2004 | Science in China Series G: Physics and Astronomy2004，，2： | 1 |
| 13 | Signal generation in an isotropic medium in scanning electron acoustic microscope显示文摘在裁判员基于研究。[5 ][ 材料科学和工程, 1989; A122:57-63 ],热来源的一个改进模型被建立,在一根砍的电子横梁在频率 f 产生的一件各向同性的样品的兰姆波浪的不同模式与不可分的变换和正常功能扩大方法被获得,并且在样品的背表面联合的 PZT 的输出信号被发现。缝接(扫描电子声学的显微镜学) 的产生机制信号被讨论。它证明 SEAM 是有高空间的分辨率的一种近的领域成像技术,它的最好的侧面的空间分辨率关于 22a (一是集中的电子横梁的半径)缝接图象的试验性的结果的 .Some 在论文被介绍,它出现缝接的空间分辨率比 0.5 m 好、比样品的热散开长度小。因此,在缝接的近的领域成像的特性也试验性地被证明。 | QIAN Menglu PENG Ruolong | 2008 | Chinese Journal of Acoustics2008，27，2： | 1 |
| 14 | Nanoindentation Characteristics of Cement Paste and Interfacial Transition Zone in Mortar with Rice Husk Ash显示文摘The nanostructure of cementitious materials has important effects on concrete properties. The effects of rice husk ash(RHA) on cement hydration product phases and interfacial transition zone(ITZ) in mortar were investigated from the nano-scale structure perspective. The experimental results indicate that, with the increase of RHA dosages of samples, the volume fraction of high-density calcium-silicate-hydrate(HD C-S-H) in porosity and hydration product phases increases. The volume fractions of HD C-S-H in C-S-H of samples show an increasing trend with the increase of RHA dosages. RHA decreases the thickness of ITZ and increases the matrix elastic moduli of samples, however, the RHA dosoges hardly affect the thickness and elastic moduli. | 何智海 QIAN Chunxiang 杜时贵 HUANG Man XIA Menglu | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，2： | 1 |
| 15 | Measurement of small vibration by laser interferometer显示文摘The method and experimental results of measuring a small vibrating displacement by laser interferometer are introduced in this paper. The dynamic response of a new kind of tiny piezoelectric driver is detected. Results show that this kind of PZN-PZT tiny driver not only has high voltage-displacement sensitivity, but also its frequency response approaches to 1 kHz.Therefore this kind of piezoelectric driver can be used widely in many fields. | QIAN Menglu, LIU Hewei (Institute of Acoustics, Tongji University, Shanghai 200092) | 2003 | 声学技术2003，22，z1： | 0 |
| 16 | Study of characteristics of ultrasound pulse generated by a laser pulse显示文摘The one-dimension thermal conduction equation and Navier-Stokes equa tion are used to get a pulse stress wave in a scmi-infinitc medium when a rectangular pulse laser of duration t0 is incident on its surface. For both tfansparent and opaque samples the ultrasonic stress waveforms arc discussed when the sample surface is con strained or free. The experimental results in these two different boundary conditions of an opaque sample are presented. It is shown, theoretically and experimentally,that the ultrasound pulse thermoelastically generated by a pulse laser is monopolar when the sample surface is constrained and it is bipolar when its surface is free. | QIAN Menglu ZHANG Wanchun and WU Tiancheng (Institute of Acoustics. Tongji Uaiversity. Shanghai 200092) | 1994 | Chinese Journal of Acoustics1994，13，3： | 0 |
| 17 | New thermoelastic technique for detection of residual stress distribution in solids显示文摘Bascd on the non- linear thermoclastic theory, the temperature field and displacement field in a prestressed sample are obtaincd when a one-dimensional heat disturbance is applied to it. By using piezoelectric equations the relationship between the output signal of PZT transducer, which is coupled to the back surface of the sample, and initial stress in sample is found. The photoacoustic and SEAM experimental results about residual stress distributions in Vicker’s indentation on Al disks are presented. It is shown that the undfilating distribution of stress in the indentation can be estimated by the thermoclasic technique. | QIAN Menglu(Institute of Acoustics. Tongji University, Shanghai 200092) | 1995 | Chinese Journal of Acoustics1995，14，2： | 0 |
| 18 | Signal generation and spatial resolution in scanning electron acoustic microscopy显示文摘The thermal conduction and Navier-Stokes equations are usedto obtain the stress field generated by a chopped electron beam incident ona disk sample.The piezoelectric equation is then used to obtain the out-put signal of the transducer coupled to the sample.The results lead to aconsideration of the signal generation mechanism and spatial resolution inscanning electron acoustic microscopy(SEAM).It is shown that atime-variant heat source generated both a thermal wave and an acousticwave simultaneously,and thermal-to-acoustic wave mode conversion oc-cured on the boundary surfaces depends on the amplitudes and the gra-dients at boundary surfaces of both heat source and thermal waves.It isargued that the spatial resolution of a imaging system operated in thenear field,such as SEAM and thermal wave microscope,is dependent onthe distance between the heat source and scatterer and,at best,the lateralresolution in SEAM is of the order of the diameter of the focal spot ofthe electron beam. | QIAN Menglu Jhon H.CANTRELL | 1991 | Chinese Journal of Acoustics1991，10，3： | 0 |
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