| 1 | Geochronology and geochemistry of Cretaceous-Eocene granites,Tengchong Block(SW China):Petrogenesis and implications for Mesozoic-Cenozoic tectonic evolution of Eastern Tethys显示文摘The Early Cretaceous-Early Eocene granitoids in the Tengchong Block record the evolutionary history of the Mesozoic-Cenozoic tectono-magmatic evolution of Eastern Tethys.(a)The Early Cretaceous granitoids with relatively low(^(87)Sr/^(86)Sr)iratios of 0.7090-0.7169 andε_(Nd)(t)values of-9.8 to-7.8 display metaluminous,calc-alkaline dominated by I-type granite affinity and hybrid mantle-crust geochemical signatures.They may have been derived from melting of the subducted Meso-Tethyan BangongNujiang oceanic crust with terrigenous sediments in an arc-continent collisional setting.(b)The Late Cretaceous-Paleocene granitoids with relatively high(^(87)Sr/^(86)Sr)iratios of 0.7109-0.7627,andε_(Nd)(t)values of-12.1 to-7.9 exhibit metaluminous to peraluminous,calc-alkaline dominated by S-type granite affinity and hybrid Lower-Upper crust geochemical signatures,which may be originated from partial melting of the Meso-Proterozoic continental crust in the collision setting between the Tengchong Block and Baoshan Block.(c)The Early Eocene granitoids have metaluminous,calc-alkaline I-type and S-type granites dual affinity,with relatively high(^(87)Sr/^(86)Sr)iratios of 0.711-0.736,ε_(Nd)(t)values of-9.4 to-4.7,showing crust-mantle mixing geochemical signatures.They may have been originated from partial melting of the late Meso-Proterozoic upper crustal components mixed with some upper mantle material during the ascent process of mantle magma caused by the subduction of the Neo-Tethyan Putao-Myitkyian oceanic crust,and collision between the Western Burma Block and the Tengchong Block.It is these multi-stage subductions and collisions that caused the spatial and temporal distribution of the granitic rocks in the Tengchong Block. | Yongqing Chen Guangjie Li Luxue Qin Yingxiang Lu Chengxing Jiang | 2022 | Geoscience Frontiers2022，13，2： | 3 |
| 2 | Acupotomy ameliorates subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis by regulating bone morphogenetic protein 2-Smad1 pathway显示文摘OBJECTIVE:To investigate the effects of acupotomy on the subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis(KOA).METHODS:The rabbits were divided into blank control,model,acupotomy and electroacupuncture(EA)groups,with 12 rabbits in each.Modified Videman's method was used to prepare KOA model.The acupotomy and EA group were given indicated intervention for 3 weeks.The behavior of rabbits in each group was recorded.Subsequently,cartilage–subchondral bone units were obtained and morphological changes were observed by optical microscope and micro computed tomography.Compression test was used to detect the mechanical properties of subchondral bone,Western blot and real-time polymerase chain reaction(RT-PCR)were applied to detect the expression of bone morphogenetic protein 2-Smad1(BMP2-Smad1)pathway in subchondral bone.RESULTS:Compared with the control group,rabbits in the KOA group showed lameness,knee pain,and cartilage degradation;the subchondral bone showed active resorption,the mechanical properties decreased significantly and the BMP2-Smad1 pathway downregulated significantly.Both acupotomy and EA intervention could increase the thickness of trabecular bone(Tb.Th),the bone volume fraction(BV/TV)and the thickness of subchondral bone plate,reduce the separation of trabecular bone(Tb.Sp),improve the maximum load and elastic modulus of subchondral bone,and effectively delay cartilage degeneration in KOA rabbits.This process may be achieved through upregulation the related proteins of BMP2-Smad1 pathway.The maximum load and elastic modulus of subchondral bone in the acupotomy group were slightly better than those in the EA group.CONCLUSIONS:Acupotomy could effectively protect cartilage by inhibiting abnormal bone resorption and improving mechanical properties of subchondral bone thorough the related proteins of BMP2-Smad1 pathway in KOA rabbits. | Chen Xilin GUO Yan LU Juan QIN Luxue HU Tingyao ZENG Xin WANG Xinyue ZHANG Anran ZHUANG Yuxin ZHONG Honggang GUO Changqing | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
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