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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks显示文摘Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its therapeutic use has been limited due to its carcinogenic potential. Plant-derived phytoestrogens are attractive alternatives, but reports on their angiogenic activities often lack in-depth analysis and sometimes are controversial. Herein, we report a data-mining study with the existing literature, using IPA system to classify and characterize phytoestrogens based on their angiogenic properties and pharmacological consequences. We found that pro-angiogenic phytoestrogens functioned predominantly as cardiovascular protectors whereas anti-angiogenic phytoestrogens played a role in cancer prevention and therapy. This bidirectional regulation were shown to be target-selective and, for the most part, estrogen-receptor-dependent. The transactivation properties of ERα and ERβ by phytoestrogens were examined in the context of angiogenesis-related gene transcription. ERα and ERβ were shown to signal in opposite ways when complexed with the phytoestrogen for bidirectional regulation of angiogenesis. With ERα, phytoestrogen activated or inhibited transcription of some angiogenesis-related genes, resulting in the promotion of angiogenesis, whereas, with ERβ, phytoestrogen regulated transcription of angiogenesis-related genes, resulting in inhibition of angiogenesis. Therefore, the selectivity of phytoestrogen to ERα and ERβ may be critical in the balance of pro- or anti-angiogenesis process. | LIU Hai-Xin WANG Yu LU Qing YANG Ming-Zhu FAN Guan-Wei KARAS Richard H GAO Xiu-Mei ZHU Yan | 2016 | Chinese Journal of Natural Medicines2016，14，4： | 4 |
| 3 | Reactive nitrogen and oxygen species ameliorate experimental cyptosporidiosis in the neonatal BALB/c mouse mode显示文摘 | Leitch GJ and Qing H | 1999 | Infetion and Immunity1999，67，1： | 2 |
| 4 | Structure and composition of selectively cut and uncut Abies-Tsuga forest in Wolong natural reserve and implica- tions for Panda conservation in China 显示文摘 | Taylor A H Qing Z S | 1989 | Biological Conservation1989，47，2： | 1 |
| 5 | Clonal integration enhances flood tolerance of Spartina alterniflora daughter ramets显示文摘 | Xiao Y Tang J B Qing H | 2010 | Aquatic Botany2010，92，1： | 1 |
| 6 | An FDTD formulation for dispersive media using a current density显示文摘 | Chen Qing Katsurai M Aoyagi P H | 1998 | IEEE Trans Antennas Propagat1998，46，10： | 1 |
| 7 | Promoter methylation of APC and RAR-~ genes as prognostic markers in non- small cell lung cancer (NSCLC)显示文摘 | Feng H Zhang Z Qing X | 2016 | Exp Mol Pathol2016，100，1： | 1 |
| 8 | Arginine-derived nitric oxide reduces facal oocyst shedding in nude mice infected with Cryptosporidium parvum显示文摘 | Leitch G J Qing H E | 1994 | Infection and Immunity1994，62，11： | 1 |
| 9 | The Recombinant Nonstructural Polyprotein NS1 of Porcine Parvovirus (PPV) as Diagnostic Antigen in ELISA to Differentiate Infected from Vaccinated Pigs显示文摘 | QING L LV J LI H | 2006 | Vet Res Commun2006，30，2： | 1 |
| 10 | Analysis of CYP3A4 genetic polymor- phisms in Hart Chinese 显示文摘 | Qing Z Songnian H | 2011 | Journal of Human Genetics2011，56，6： | 1 |
| 11 | Rare earth element geochemistry of dolomites in the Middle Devonian Presqulle barrier, Western Canada Sedimentary Basin: implications for fluid-rock ratios during dolomitization 显示文摘 | Qing H Mountjoy E W | 1994 | Sedimentology1994，41，4： | 1 |
| 12 | Distributed module of intrusion detection system based on Agent 显示文摘 | Ma H T Qing S H Chen W F | 2001 | Journal of software2001，11，10： | 1 |
| 13 | Mechanical induction of PGE2in osteocytes blocks glucocorticoid-induced apoptosis throughboth the β-catenin and PKA pathways显示文摘 | Kitase Y Barragan L Qing H | 2010 | J Bone Miner Res2010，25，12： | 1 |
| 14 | Shuo, Theory and method of mechanism system design 显示文摘 | Jun Z H Hua L Q Qing z | 2010 | Frontiers of Mechanical Engineering in China2010，5，4： | 1 |
| 15 | A 3D multilevel model of damage and strength of wood; Analysis of microstructural effects 显示文摘 | QING H MISHNAEVSKY L | 2011 | Mechanics of Materials2011，43，9： | 1 |
| 16 | Synthesis of 4,6- disubstituted pyrimidines via suzuki and kumada coupling reaction of 4,6-dichloropyrimidine 显示文摘 | Qing F L Wang R W Li B H | 2003 | J Fluorine Chem2003，120，1： | 1 |
| 17 | Regeneration of N, P and Si near the sediment/water interface of lakes from Southwestern China Plateau显示文摘 | Wu F Qing H Wan G | 2001 | Water Research2001，35，5： | 1 |
| 18 | The response of composite joints with bolt - lamping loads 显示文摘 | Sun H T Chang Fukuo Qing Xinlin | 2002 | Journal of Composite Materials2002，36，1： | 1 |
| 19 | Monodisperse magnetic single-crystal ferrite microspheres 显示文摘 | Deng H Li X L Qing P | 2005 | Angewandte Che- mie : International Edition2005，117，44： | 1 |
| 20 | p21-activated Kinase 5 inhibits camptothecin-induced apoptosis in colorectal car- cinoma cells显示文摘 | Wang X Gong W Qing H | 2010 | Tumour Bio12010，31，6： | 1 |
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