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| 1 | Changing trends in the mortality rate at 1-year post hip fracture-a systematic review显示文摘BACKGROUND Traditionally, the mortality rate at 1-year post hip fracture was quoted as approximately 30% of all hip fractures. There have been recent improvements in hip fracture care in the main driven by national hip fracture registries with reductions in 30-d mortality rates reported.AIM To address recent 1-year post hip fracture mortality rates in the literature.METHODS Systematic literature review, national hip fracture registries/databases, local studies on hip fracture mortality, 5 years limitation(2013-2017), cohorts > 100,studies in English. Outcome measure: Mortality rate at 1-year post hip fracture.RESULTS Recent 1-year mortality rates were reviewed using the literature from 8 National Registries and 36 different countries. Recently published 1-year mortality rates appear lower than traditional figures and may represent a downward trend.CONCLUSION There appears to be a consistent worldwide reduction in mortality at 1-year post hip fracture compared to previously published research. Globally, those which suffer hip fractures may currently be benefiting from the results of approximately 30 years of national registries, rigorous audit processes and international collaboration. The previously quoted mortality rates of 10% at 1-mo and 30% at 1-year may be outdated. | Colum Downey Martin Kelly John F Quinlan | 2019 | World Journal of Orthopedics2019，10，3： | 17 |
| 2 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 3 | Bidirectional experience-dependent regulation of N-methyl-d-aspartate receptor subunit composition in the rat visual cortex during postnatal development显示文摘 | Quinlan E M Olstein D H Bear M F | 1999 | Proc Natl Acad Sci USA1999，96，12： | 1 |
| 4 | The use of uncementedextensively porous-coated femoral componentsin the management of Vancouver B2 and B3 periprostheticfemoral fractures显示文摘 | O'Shea K Quinlan J F Kutty S | | 0，，12： | 1 |
| 5 | The use of un-cemented extensively porous-coated femoral componentsin the management of Vancouver B2 and B3 periprosthet-ic femoral fractures显示文摘 | O'Shea K Quinlan J F Kutty S | 2005 | J Bone Joint Surg Br2005，87，12： | 1 |
| 6 | Investigations of gas and particle dynamics in first generation needle-free drug delivery device显示文摘 | QUINLAN N J KENDALLl M A F BBLLHOUSE B J | 2001 | Shock Waves2001，10，： | 1 |
| 7 | The role of hydrodynamics in explaining variability in fish populations 显示文摘 | WERNER F E QUINLAN J A BLANTON B O | 1997 | Journal of Sea Research1997，，37： | 1 |
| 8 | Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: role of poly (adenosine 5'-diphosphoribose) synthase显示文摘 | Mitchell JA Quinlan GJ | 1997 | Br J Pharmacol1997，121，3： | 1 |
| 9 | Reverse micelle synthesis and characterization of ZnSe nanoparticals显示文摘 | Quinlan F T Kuther J Trend W | 2000 | Langmuir2000，16，8： | 1 |
| 10 | Inhi- bition of amyloid 显示文摘 | CABALEIRO L C QUINLAN P F LYNCH I | 2008 | J Am Chem Soc2008，130，15： | 1 |
| 11 | Larval trans- port during winter in the SABRE study area: results of a coupled vertical larval behaviour-three-dimensional cir- culation model 显示文摘 | Hare J A Quinlan J A Werner F E | 1999 | Fisheries Oceanography1999，8，： | 1 |
| 12 | Synergistic interactions between carotene ring hydroxylases drive lutein formation in plant carotenoid biosynthesis显示文摘 | Quinlan R F Shumskaya M Bradbury L M | 2012 | Plant Physiology2012，160，1： | 1 |
| 13 | Workplace exposures and the risk of amyotrophic lateral sclerosis显示文摘 | Fang F Quinlan P Ye W | 2009 | Environ Health Perspect2009，117，9： | 1 |
| 14 | Demonstration of on-sky calibration of astronomical spectra using a 25 GHz near-IR laser frequency comb显示文摘 | YCAS G G QUINLAN F DIDDAMS S A | 2012 | Optics Express2012，20，6： | 1 |
| 15 | Nitric oxide and salicylic acid signaling in plant defense显示文摘 | Klessig D F Quinlan M P Grodzicker T | 2005 | Proceedings of National Academy of Sciences of the Unites of America2005，97，： | 1 |
| 16 | Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery显示文摘 | Kendall M A F Quinlan N J Thorpe S J | 2004 | Experiments in Fluids2004，37，1： | 1 |
| 17 | Reverse micelle synthesis and characterization of ZnSe nanoparticles显示文摘 | Quinlan F T Kuther J Tremel W | 2000 | Langmuir2000，16，： | 1 |
| 18 | Bovine filensin possesses primary and secondary structure similarity to intermediate filament proteins显示文摘 | Gounari F Merdes A Quinlan R | 1993 | J Cell Biol1993，121，4： | 1 |
| 19 | Reverse micelle synthesis and characterization of ZnSe nanoparticles显示文摘 | Quinlan F T Kuther J Tremel W | 2000 | Langmuir2000，16，： | 1 |
| 20 | Investigation of gas and particle dynamics in first generation needle-free drug delivery devices显示文摘 | Kendall M A F Bellhouse B J | 2001 | Shock Waves2001，10，： | 1 |
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