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| 1 | Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma显示文摘Background: According to the 7 th edition of the American Joint Committee on Cancer(AJCC) staging system, over50% of patients with nasopharyngeal carcinoma(NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node(GTVnd) and pretreatment serum copy number of Epstein-Barr virus(EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients.Methods: The medical records of 787 newly diagnosed patients with nonmetastatic, histologically proven N1 NPC who were treated at Sun Yat-sen University Cancer Center between November 2009 and February 2012 were analyzed. Computed tomography-derived GTVnd was measured using the summation-of-area technique. Blood samples were collected before treatment to quantify plasma EBV DNA. The receiver operating characteristic(ROC) curve analysis was used to evaluate the cut-off point for GTVnd, and the area under the ROC curve was used to assess the predicted validity of GTVnd. The survival rates were assessed by Kaplan-Meier analysis, and the survival curves were compared using a log-rank test. Multivariate analysis was conducted using the Cox proportional hazard regression model.Results: The 5-year distant metastasis-free survival(DMFS) rates for patients with GTVnd > 18.9 vs.≤ 18.9 mL were82.2% vs. 93.2%(P < 0.001), and for patients with EBV DNA copy number > 4000 vs. < 4000 copies/mL were 83.5% vs.93.9%(P < 0.001). After adjusting for GTVnd, EBV DNA copy number, and T category in the Cox regression model, both GTVnd > 18.9 mL and EBV DNA copy number > 4000 copies/mL were significantly associated with poor prognosis(both P < 0.05). According to combination of GTVnd and EBV DNA copy number, all patients were divided into low-,moderate-, and high-risk groups, with the 5-year DMFS rates of 96.1,87.4, and 73.8%, respectively(P < 0.001). Multivariate analysis confirmed the prognostic value of this model for distant metastatic risk stratification(hazard ratio [HR],4.17; 95% confidence interval [CI] 2.34-7.59; P < 0.001).Conclusions: GTVnd and serum EBV DNA copy number are independent prognostic factors for predicting distant metastasis in NPC patients with N1 disease. The prognostic model incorporating GTVnd and EBV DNA copy number may improve metastatic risk stratification for this group of patients. | Ji‑Jin Yao Guan‑Qun Zhou Ya‑Qin Wang Si‑Yang Wang Wang‑Jian Zhang Ya‑Nan Jin Fan Zhang Li Li Li‑Zhi Liu Zhi‑Bin Cheng Jun Ma Zhen‑Yu Qi | 2017 | Chinese Journal of Cancer2017，36，12： | 9 |
| 2 | Chemical comparison of dried rehmannia root and prepared rehmannia root by UPLC-TOF MS and HPLC-ELSD with multivariate statistical analysis显示文摘To identify the chemical differences which lead to the different therapeutic effects of dried rehmannia root(DRR)and prepared rehmannia root(PRR),we compared the chemical composition of decoctions of randomly purchased DRR and PRR using ultra performance liquid chromatography(UPLC)coupled with time-of-fight mass spectrometry and high performance liquid chromatography(HPLC)coupled with evaporative light scattering detection(ELSD)with the aid of multivariate statistical analysis.Both approaches clearly revealed compositional and quantitative differences between DRR and PRR.UPLC-MS data indicated stachyose,rehmaiono-side A(or rehmaionoside B),acteoside(or forsythiaside,or isoacteoside),6-O-coumaroylajugol(or 6-O-E-feruloylajugol,or 6-O-Z-feruloylajugol)as important discriminators between DRR and PRR decoctions.HPLC-ELSD analysis showed that the content of fructose in the decoctions of PRR was about four times greater than that of DRR(P<10^(-5)),while sucrose content in the decoctions of PRR was only about one seventh of that in DRR(P<0.01).Our results suggest that some compounds,such as fructose,stachyose and rehmaionoside,may be responsible for the differing therapeutic effects of DRR and PRR.Furthermore,improvements in quality control for PRR,which is currently lacking in the Chinese Pharmacopoeia,are recommended. | Qiande Liang Jing Ma Zengchun Ma Yuguang Wang Hongling Tan Chengrong Xiao Ming Liu Beibei Lu Boli Zhang Yue Gao | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 8 |
| 3 | Bmi-1 is required for maintenance of adult self- renewing haematopoietie stem cells显示文摘 | ParklK QianD KielM etal | 2003 | Nature2003，423，6937： | 1 |
| 4 | Surgical reconstruction of comminuted coronoid fracture in terrible triad injury of the elbow显示文摘 | Hong Wu Qiande Liao Yong Zhu Hua Liu | 2012 | European Journal of Orthopaedic Surgery & Traumat2012，，： | 1 |
| 5 | Bmi-1 is required for mainte- nance of adult self-renewing haematopoietic stem ceils 显示文摘 | PARK I K QIAND ' - - KIELM | 2003 | Nature2003，423，6937： | 1 |
| 6 | Recentprogressincathodematerialsresearchforadvancedlithiumionbatteries显示文摘 | XuB QianD WangZ etal | 2012 | MaGterialsScienceandEngineering2012，73，56： | 1 |
| 7 | Semantics-preserving dimensionality reduction rough and fuzzy rough-based aproaches显示文摘 | CHARD J QIAND S | 2004 | IEEE Transactions on Knowledge and Data Engineering2004，16，12： | 1 |
| 8 | Effects of four Si - Wu Tang' s constituents and their combination on irradiated mice 显示文摘 | Qiande L Yue G Hongling T | 2006 | Bio Pharm Bull2006，29，7： | 1 |
| 9 | Measurements of turbulent transfer in the near-surface layer over the southeastern TIBETEN plateau显示文摘 | Bian Lingen Gao Zhiqiu Xu Qiande | 2002 | Boundary-layer Meteorology2002，102，： | 1 |
| 10 | Determination of ligustilide in the brains of freely moving rats using microdialysis coupled with ultra performance liquid chromatography/mass spectrometry 显示文摘 | GuoJ M Shang E X Duan J A Tang Y QianD | 2011 | Fitoterapia2011，82，： | 1 |
| 11 | Research on Concrete Beam Crack Recognition Algorithm Based on Block Threshold Value Image Processing显示文摘To solve the problem that the digital image recognition accuracy of concrete structure cracks is not high under the condition of uneven ill umination and complex surface color of concrete structure,this paper has proposed a block segmentation method of maximum entropy threshold based on the digital image data obtained by the ACTIS automatic detection system.The steps in this research are as follows:1.The crack digital images of concrete specimens with typical fea-tures were collected by using the Actis system of KURABO Co,Ltd,of Japan in the concrete beam bending test.2.The images are segmented into blocks to dis-tinguish backgrounds of different grayscale.3.The max imum interclass average gray difference method is used to distinguish the sub-blocks and screen out the image blocks that need to be segmented.4.Segmentation is made to the image with 2D max imum entropy threshold segmentation method to obtain the binary image,and the target image can be obtained by screening the connected domain features of the binary image.Results have shown that compared with other algo-rithms,the proposed method can effectively decrease the image over-segmentation and under segmentation rates,highlight the characteristics of the target cracks,solve the problems of excessive difference between the identified length and actual length of cracks caused by background gray level change and uneven ilumnination,and effectively improve the recognition accuracy of bridge concrete cracks. | Wenting Qiao Xiaoguang Wu Wen Sun Qiande Wu | 2020 | Structural Durability & Health Monitoring2020，14，4： | 0 |
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