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| 1 | Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients显示文摘Dear Editor,In late December 2019,an outbreak of severe pneumonia caused by an unknown etiological agent was initially reported in Wuhan,China,and then quickly spread throughout China and even abroad(Zhu et al.,2020).Swift control measures and etiological investigations were conducted by the Chinese government,physicians and researchers,and by using high throughput sequencing and virological testing,the mysterious pneumonia pathogen was shown to be a novel coronavirus(SARS-CoV-2)capable of person-to-person transmission(Zhu et al.,2020).Coronaviruses are a group of non-segmented,enveloped and positive-sense RNA viruses that belong to the subfamily of Coronavirinae in the family of Coronavirdiae and order of Nidovirales. | Dachuan Lin Lei Liu Mingxia Zhang Yunlong Hu Qianting Yang Jiubiao Guo Yongchao Guo Youchao Dai Yuzhong Xu Yi Cai Xinchun Chen Zheng Zhang Kaisong Huang | 2020 | Science China(Life Sciences)2020，63，4： | 6 |
| 2 | Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression显示文摘Background:Cancer cells selectively promote the translation of oncogenic tran-scripts to stimulate cancer progression.Although growing evidence has revealed that tRNA modifications and related genes participate in this process,their roles in head and neck squamous cell carcinoma(HNSCC)remain largely unchar-acterized.Here,we sought to investigate the function and mechanisms of the transfer RNA(tRNA)N7-methylguanosine(m'G)modification in regulating the occurrence and development of HNSCC.Methods:Cell lost of-function and gain-of function assays,xenograft models,conditional knockout and knockin mouse models were used to study the physi-ological functions of tRNA m'G modification in HNSCC tumorigenesis.tRNA modification and expression profiling,mRNA translation profiling and res-cue assays were performed to uncover the underlying molecular mechanisms.Single-cell RNA sequencing(scRNA seq)was conducted to explore the tumor microenvironment changes.Results:The tRNA.m7G methyltransferase complex components Methyltransferase-like 1(METTL1)/WD repeat domain 4(WDR4)were upregulated in HNSCC and associated with a poor prognosis.Functionally,METTL1/WDR4 promoted HNSCC progression and metastasis in cell-based and transgenic mouse models.Mechanistically,ablation of METTL1 reduced the m'G levels of 16 tRNAS,inhibiting the translation of a subset of oncogenic transcripts,including genes related to the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling pathway.In addition,chemical modulators of the PI3K/Akt/mTOR signaling pathway reversed the effects of Mettll in mouse HNSCC.Furthermore,scRNA-seq results revealed that Mettll knockout in mouse tumor cells altered the immune landscape and cell-cell interaction between the tumor and stromal compartment.Conclusions:The tRNA m?G methyltransferase METTLI was found to promote the development and malignancy of HNSCC through regulating global mRNA translation,including the PI3K/AKT/mTOR signaling pathway,and found to alter immune landscape.METTLI could be a promising treatment target for HNSCC patients. | Jie Chen Kang Li Jianwen Chen Xiaochen Wang Rongsong Ling Maosheng Cheng Zhi Chen Fangfang Chen Qianting He Shuai Li Caihua Zhang Yizhou Jiang Qianming Chen Anxun Wang Demeng Chen | 2022 | Cancer Communications2022，42，3： | 6 |
| 3 | Investigation on the Morphological Characteristics of Dendrobium officinale Plantlets Propagated from Different Explants显示文摘[Objective]This study aimed to investigate the differences in morphological characteristics of Dendrobium officinale plantlets propagated from different explants.[Method]Randomly 1 000 D. officinale plantlets propagated via different regeneration pathways were selected for morphological investigation and classification.[Result] D. officinale plantlets propagated from stem segment explants exhibited highly consistent morphological characteristics,while those propagated from seed explants exhibited a variety of morphological characteristics.[Conclusion] Therefore,using seed explants for regeneration can effectively broaden the germplasms resources of D. officinale. | Jiaxian LIANG Junjie MO Hancai CAO Qianting TAN | 2014 | Agricultural Biotechnology2014，3，5： | 5 |
| 4 | Surface borehole synthesis tension deformation fracture time-space rule显示文摘In order to release the tension and shear effect of the superjacent rock strata movement during excavation in coal mine,protect the surface borehole case from fracturing fast and make a good use of the surface borehole during goaf methane drawing,a common synthesis tension deformation fracture model was set up based on the synthesis tension effect of the rock strata,and the deformation rule of the surface borehole case with time and space was researched.The results suggest that,to reduce the deformation the surface borehole should be built between the boundary of the stope and the knee of subsidence curve.At the same time,a 3DEC simulation model and an engineering example were carried out to examine the rules of theoretical model.The result suggests that the model and the rules accord to the test and have good building and protection engineering application values to the surface borehole. | Liu Jianzhong Sun Haitao Hu Qianting | 2012 | International Journal of Mining Science and Technology2012，22，4： | 5 |
| 5 | Modeling and assessing international climate financing显示文摘资助的气候是在气候保护的当前的协商的一个关键问题。这研究建立基于施主国家为资助的气候和接受者国家使用在建立了资金的机制资助模型的气候专门为碳排放的资金减小。分享负担的原则基于 GDP,历史的排出物,和 consumptionbased 排出物。用这个模型,我们发展并且分析一系列情形模拟,包括在 Cancun 气候变化会议(2010 ) 达成的一个资助节目和几个随后的节目。结果证明资助的那持续气候能帮助与全球气候作斗争变化。然而, Cancun 协议被投射导致减小仅仅 0.01 ? 鷸吗?? | Jing WU Lichun TANG Rayman MOHAMED Qianting ZHU Zheng WANG | 2016 | Frontiers of Earth Science2016，10，2： | 2 |
| 6 | Bi_(2)S_(3) spheres coated with MOF-derived Co_(9)S_(8) and N-doped carbon composite layer for half/full sodium-ion batteries with superior performance显示文摘Bismuth sulfide(Bi_(2)S_(3))has attracted particular interest as a potential anode material for sodium-ion batteries(SIBs).However,the low electrical conductivity and dramatic volumetric change greatly restrict its practical applications.In view of the apparent structural and compositional advantages of metal-organic frameworks(MOFs)derived carbon-based composite,herein,as a proof of concept,Bi_(2)S_(3) spheres coated with the MOF-derived Co_(9)S_(8) and N-doped carbon composite layer(Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres)have been rational designed and synthesized.As expected,the core-shell Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres exhibit remarkable electrochemical performance in terms of high reversible capacity(597 m Ah g^(-1) after 100 cycles at 0.1 A g^(-1)),good rate capability(341 m Ah g^(-1) at 8 A g^(-1))and long-term cycling stability(458 m Ah g^(-1) after 1000 cycles at 1 A g^(-1))when investigated as anode materials for SIBs.Electrochemical analyses further reveal the favorable reaction kinetics in the Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres.In addition,the possible sodium storage mechanism has been studied by ex-situ X-ray diffraction technique.More importantly,a sodium-ion full cell based on Na_(3) V_(2)(PO_(4))_(3)/r GO as cathode and Bi_(2)S_(3)@Co_(9)S_(8)/NC as anode is also fabricated,suggesting their potential for practical applications.It is anticipated that the present work could be extended to construct other advanced electrode materials using MOFs-derived carbon-based composites as surface coating materials for various energy storagerelated applications. | Youzhang Huang Xueshuang Zhu Daoping Cai Zhixiang Cui Qianting Wang Hongbing Zhan | 2021 | Journal of Energy Chemistry2021，30，8： | 2 |
| 7 | Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H 2 O 2 -dependent Snail signaling显示文摘 | Zhonghua Liu Su Li Yuchen Cai Anxun Wang Qianting He Chaoxu Zheng Tingting Zhao Xueqiang Ding Xiaofeng Zhou | 2012 | Free Radical Biology and Medicine2012，，1： | 1 |
| 8 | Research on comprehensive early-warning technology of coal and gas outburst显示文摘 | ZHAO Xusheng HU Qianting NING Xiaoliang | 2011 | Procedia Engineering2011，26，： | 1 |
| 9 | Diagnosis of Ac- tive Tuberculosis in China Using an In-House Gamma Interferon En- zyme-Linked Immunospot Assay显示文摘 | Xinchun Chen Qianting :ang Mingxia Zhang | 2009 | Clin Vaccine Immunol2009，16，16： | 1 |
| 10 | A preliminary laboratory experiment on coalbed methane displacement with carbon dioxide injection显示文摘 | Hongguan Yu Jian Yuan Weijia Guo Jiulong Cheng Qianting Hu | 2007 | International Journal of Coal Geology2007，，2： | 1 |
| 11 | A preliminary laboratory experiment on coalbed methane displacement with carbon dioxide injection显示文摘 | Hongguan Yu Jian Yuan Weijia Guo Jiulong Cheng Qianting Hu | 2007 | International Journal of Coal Geology2007，，2： | 1 |
| 12 | Research on comprehensive early - warning technology of Coal and gas outburst显示文摘 | Zhao xusheng Hu qianting Ning xiaoliang | 2011 | Procedia Engineering2011，26，： | 1 |
| 13 | Gap distribution between fragile insert and mold in plastic boundary injection forming显示文摘 | Wang Qianting Liu Qiong Chen Wenzhe | | 0，，12： | 1 |
| 14 | Research on comprehensive early-warning technology of Coal and gas outburst 显示文摘 | Zhao xusheng Hu qianting Ning xiaoliang | 2011 | Procedia Engineering2011，26，： | 1 |
| 15 | A global dataset of Palmer drought severity index for 1870-2002:Relationship with soil moisture and effects of surface warming显示文摘 | DAI A G TRENBERTH K E QIANT T | | 0，，6： | 1 |
| 16 | Irreversible adsorption of human serum albumin to hydrogel contact lenses: a study using electron spin resonance spectroscopy 显示文摘 | Qiant G Griesser H J Milthorpe B K | 1999 | Biomaterials1999，，20： | 1 |
| 17 | Distinct lung microbial community states in patients with pulmonary tuberculosis显示文摘An improved understanding of the lung microbiome may lead to better strategies to diagnose, treat, and prevent pulmonary tuberculosis (PTB). However, the characteristics of the lung microbiomes of patients with TB remain largely undefined. In this study, 163 bronchoalveolar lavage (BAL) samples were collected from 163 sputum-negative suspected PTB patients. Furthermore, 12 paired BAL samples were obtained from 12 Mycobacterium tuberculosis-positive (MTB+) patients before and after negative conversion following a two-month anti-TB treatment. The V3–V4 region of the 16S ribosomal RNA (rRNA) gene was used to characterize the microbial composition of the lungs. The results showed that the prevalence of MTB in the BAL samples was 42.9% (70/163) among the sputum-negative patients. The α-diversity of lung microbiota was significantly less diverse in MTB+ patients compared with Mycobacterium tuberculosis-negative (MTB–) patients. There was a significant difference in β-diversity between MTB+ and MTB– patients. MTB+ patients were enriched with Anoxybacillus, while MTB– patients were enriched with Prevotella, Alloprevotella, Veillonella, and Gemella. There was no significant difference between the Anoxybacillus detection rates of MTB+ and MTB– patients. The paired comparison between the BAL samples from MTB+ patients and their negative conversion showed that BAL negative-conversion microbiota had a higher α-diversity. In conclusion, distinct features of airway microbiota could be identified between samples from patients with and without MTB. Our results imply links between lung microbiota and different clinical groups of active PTB. | Yongfeng Hu Ying Kang Xi Liu Min Cheng Jie Dong Lilian Sun Yafang Zhu Xianwen Ren Qianting Yang Xinchun Chen Qi Jin Fan Yang | 2020 | Science China(Life Sciences)2020，63，10： | 1 |
| 18 | Fabrication and Characterization of 3D Graded PDMS Scaffolds Using Vacuum-Assisted Resin Transfer Moulding显示文摘Graded porous scaffold can be applied to study the interactions between cells and scaffold with different pore sizes. Polydimethylsiloxane(PDMS) scaffold with an axial pore size grade was successfully manufactured via vacuum-assisted resin transfer moulding(VARTM) and particle leaching technologies. The properties of graded PDMS scaffolds, including porosity, water absorption, interconnectivity, compression modulus, as well as compression strength were investigated. The results showed that the smaller the size of the NaCl particles is, the higher the porosity and water absorption of graded PDMS scaffolds would be. The graded PDMS scaffold fabricated had a compressive modulus and a compressive strength of 19.69±1.42 kPa and 4.76±0.22 kPa, respectively. Moreover, the graded chitosan(CS)-coated PDMS scaffolds were prepared by using dip-coating technique under low vacuum and their hydrophilicity was examined. It is found that the water contact angle(WCA) will decrease with an increase in the CS solution concentration and the coating time, which indicates that CS-coated PDMS scaffolds exhibit noticeable hydrophilicity compared with graded PDMS scaffold. | 司军辉 LIN Jiahe ZHENG Zifeng CUI Zhixiang WANG Qianting | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 1 |
| 19 | Coal-like material for coal and gas outburst simulation tests显示文摘 | Qianting Hu Shutong Zhang Guangcai Wen | 2015 | International Journal Of Rock Mechanics And Mining Sciences2015，74，： | 1 |
| 20 | Resistivity response of coal under hydraulic fracturing with different injection rates:A laboratory study显示文摘Resistivity will have different response characteristics to the hydraulic fracture propagation process. In this work, a resistivity testing system for hydraulic fracturing specimens was established. Resistivity and acoustic emission(AE) information were jointly analysed to determine the dynamic response characteristics of resistivity during hydraulic fracture propagation. The results show that the water and fracture exert a competitive influence on the connection structure of the circuit, and there are two significant peak resistivity points in the curve, presenting a double peak therein. The peak resistivity data of the specimen with a larger fracture area are much different from the initial value. With the increase of the rate of injection, the range of variation of the highest value that can be reached with the specimen resistivity decreases. High resistivity rates or high resistivity fluctuations exhibit rapid a release of fracture energy. The fracture failure mode dominated by shear fractures makes the formation produce a “series+parallel” electrical connection structure;a calculation model of formation resistivity based on shear and tensile failure was proposed to characterize the proportion of different types of hydraulic fractures and elucidate the control effect of matrix resistivity on the electrical performance of the overall circuit structure. | Mingyang Song Quangui Li Qianting Hu Yanqing Wu Guanhua Ni Yangcheng Xu Yuebing Zhang Liangping Hu Jialin Shi Jichuan Liu Yize Deng | 2022 | International Journal of Mining Science and Technology2022，32，4： | 1 |
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