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| 1 | Isolation,Characterization,and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province,China显示文摘Crimean-Congo hemorrhagic fever(CCHF)caused by the CCHF virus(CCHFV)is a tick-borne natural focal disease with a mortality rate of approximately 50%.CCHFV is widely prevalent in Africa,southern Asia,the Middle East,and southeast Europe.CCHF outbreaks have been reported previously in Xinjiang province,China,especially in its southern region.Epidemiological surveys conducted on ticks and animals have revealed the presence of CCHFV strains in ticks,rodents,and infected individuals from cities and counties in southern Xinjiang.Phylogenetic analyses revealed that the Chinese CCHFV strains belong to one genotype,based on complete sequences of the S segments of its negative-stranded RNA genome.The present study reports two new CCHFV strains isolated from Hyalomma asiaticum asiaticum ticks collected from Fukang City and Wujiaqu City in the northern region of Xinjiang.Viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription PCR analyses;these analyses indicated that the genotype of both strains was different from that of other Chinese strains.Furthermore,previous reports of CCHFV in Xinjiang were reviewed and phylogenetic analyses were performed.CCHFV was found to prevail in Fukang City in Junggar Basin for more than 20 years,and that Fukang City and Wujiaqu City are considered natural reservoirs of different genotypes of CCHFV strains.Our findings facilitate the understanding of CCHFV distribution in Xinjiang province and provide insights into the evolutionary relationships among Chinese CCHFV strains. | Yanfang Zhang Shu Shen Yaohui Fang Jinliang Liu Zhengyuan Su Jinhao Liang Zhong Zhang Qiaoli Wu Cheng Wang Abulikemu Abudurexiti Zhihong Hu Yujiang Zhang Fei Deng | 2018 | Virologica Sinica2018，33，1： | 8 |
| 2 | A facile surfactant-free synthesis of Rh flower-like nanostructures constructed from ultrathin nanosheets and their enhanced catalytic properties显示文摘Rh 是广泛地在许多器官的反应被使用的重要催化剂。在最近的年里,许多努力集中了于由与控制尺寸和形态学制作催化剂 nanoparticles 改进它的催化效率。然而,也把有机化合物用作反应媒介或盖住代理人的经常采用的合成线路经常在催化剂表面上导致剩余分子,它急速地接着减少催化表演。此处,我们报导甲醛经由 Rh (acac )3 的热水的减小获得的新奇 Rh 象花的结构的灵巧的、水的、没有表面活化剂的合成。唯一的 Rh nanoflowers 从 ultrathin nanosheets 被构造,其基础表面包括了 { 111 } 有 ~ 的平均厚度的方面 1.1 nm。特定的表面区域由公司脱衣测量了 79.3 是 m 2 钟声到 134.4 食火鸟的浸透的磁化 ???? 愠汬祯湩吗?? | Yaqi Jiang Jingyun Su Yanan Yang Yanyan Jia Qiaoli Chen Zhaoxiong Xie Lansun Zheng | 2016 | Nano Research2016，9，3： | 7 |
| 3 | Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South Korea.Hubei Province is one of the major SFTS epidemic areas in the central part of China.This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017.Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains.It was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously recognized.Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions.Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1.Subsequently,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/genotypes.In conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution.It provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies. | Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei Deng Shu Shen | 2021 | Virologica Sinica2021，36，2： | 2 |
| 4 | 大型水库消落带中西来稗种子耐淹性沿高程梯度的种内分化显示文摘在水文节律稳定、每年蓄水时间很长且水位涨落落差很大的水库中,生长在水库库岸消落带不同高程区域中的植物每年要面对长时间的不同强度的水淹,这种每年发生持续的水淹胁迫可能会导致水库库岸消落带中生长的植物的种子耐淹能力发生种内分化。西来稗(Echinochloa crusgalli var.zelayensis)是在三峡水库消落带中自然生长的优势一年生植物,在三峡水库消落带植被及消落带生态环境保护中发挥着重要作用。本研究的目的在于探究三峡水库消落带中生长的西来稗种子的耐淹能力是否已发生种内分化,以及此分化的发生是否与较弱的种子扩散能力有关。在本研究中,采集来自三峡水库消落带不同高程区域中生长的西来稗种子,在三峡水库即将蓄水时将所有采集的种子放置于三峡水库消落带中4个不同高程位置接受不同深度不同时长的水库蓄水水淹,同时把所有采集的种子也放置于不会被水库蓄水淹没的非消落带河岸上作为对照处理;测定种子在水中的漂浮持续时间和蓄水期间水库水位上涨速度以量化在水库蓄水水位上涨时种子的扩散能力,水库蓄水结束水退后检测放置于水库消落带和非消落带河岸上的种子的种子完好率、种子萌发能力和成苗率。研究结果发现,在经历三峡水库蓄水水淹后,西来稗种子的完好率和最终成苗率随种子母株在消落带中所处的高程的增加而显著降低,表明在三峡水库成库运行七年后,在三峡水库消落带中生长的西来稗的种子耐淹能力已发生了种内分化。三峡水库蓄水水位上涨时西来稗种子在水中较短的漂浮持续时间和水库蓄水时较慢的水位上升速度限制了西来稗种子的水媒传播和扩散距离,从而有利于西来稗种子的耐淹能力发生种内分化。 | Songping Liu Feng Lin Xiaolei Su Qiaoli Ayi Hangang Niu Shaohua Shi Binna Wan Bo Zeng Xiaoping Zhang | 2021 | Journal of Plant Ecology2021，14，1： | 0 |
| 5 | Impaired SERCA2a phosphorylation causes diabetic cardiomyopathy through impinging on cardiac contractility and precursor protein processing显示文摘Diabetic cardiomyopathy(DCM)is currently a progressive and nonstoppable complication in type 2 diabetic patients.Metabolic insults and insulin resistance are involved in its pathogenesis;however,the underlying mechanisms are still not clearly understood.Here we show that calcium dysregulation can be both a cause and a consequence of cardiac insulin resistance that leads to DCM.A western diet induces the development of DCM through at least three phases in mice,among which an early phase depends on impaired Thr^(484)-phosphorylation of sarcoplasmic/endoplasmic reticulum calcium ATPase 2a(SERCA2a)elicited by insulin resistance.Mutation of SERCA2a-Thr^(484) to a nonphosphorylatable alanine delays calcium re-uptake into the sarcoplasmic reticulum in the cardiomyocytes and decreases cardiac function at the baseline.Importantly,this mutation blunts the early phase of DCM,but has no effect on disease progression in the following phases.Interestingly,impairment of sarcoplasmic reticulum calcium re-uptake caused by the SERCA2a-Thr^(484) mutation inhibited processing of insulin receptor precursor through FURIN convertase,resulting in cardiac insulin resistance.Collectively,these data reveal a bidirectional relationship between insulin resistance and impairment of calcium homeostasis,which may underlie the early pathogenesis of DCM.Our findings have therapeutic implications for early intervention of DCM. | Chao Quan Sangsang Zhu Ruizhen Wang Jiamou Chen Qiaoli Chen Min Li Shu Su Qian Du Minjun Liu Hong-Yu Wang Shuai Chen | 2022 | Life Metabolism2022，1，1： | 0 |
| 6 | A Technique for Producing Drinking Water from Air Using Adsorbents Driven by Solar Energy: Theoretical and Experimental Research显示文摘ATechniqueforProducingDrinkingWaterfromAirUsingAdsorbentsDrivenbySolarEnergy:TheoreticalandExperimentalResearch￥ChouQiaoli;Su... | Chou Qiaoli Su Yuehong Ge Xinshi Wang Yongtang Cheng Shuxia(Department of Thermal Science and Energy Engineering, University of Science and Technology of China,Hefei, Anhui, 230026, China) | 1994 | Journal of Thermal Science1994，3，4： | 0 |
| 7 | Association between the Lung Immune Prognostic Index and mortality in patients with idiopathic inflammatory myopathy-associated interstitial lung disease显示文摘Objective:To explore the association between the Lung Immune Prognostic Index(LIPI)and 1-year all-cause mortality in patients with idiopathic inflammatory myopathy related interstitial lung disease(IIM-ILD).Methods:Patients who were diagnosed with IIM-ILD at West China Hospital,Sichuan University from January 2008 to December 2021 were retrospectively included and categorized into three groups based on LIPI.Univariable and multivariable Cox proportional hazards models were conducted to explore potential association between the LIPI and patients'mortality.Results:A total of 1116 patients were screened,and 830 were included in this study.The multivariable Cox analysis showed that,compared with patients with poor LIPI,the hazard ratio(HR)for all-cause 1-year mortality was 0.22(95%CI 0.05-0.93,P=0.04)for patients in the good LIPI group(LDH<250 IU/L and dNLR<3).After excluding patients lost to follow-up within one year,a similar result was found for LIPI(HR 0.20,95%CI 0.05-0.86;P=0.03).Conclusions:Good LIPI was independently associated with decreased risk of all-cause 1-year mortality in patients with IIM-ILD.This easy-to-obtain index might be served as a potential marker for assessing the prognosis of IIM-ILD. | Dan Luo Zhihao Zhao Caizheng Li Wenjun Zhu Wei Zhou Lirong He Huifeng Yan Qiaoli Su | 2023 | Asian Pacific Journal of Tropical Medicine2023，16，11： | 0 |
| 8 | Neuroprotective effects of low-concentration alpha-tocopherol Confocal laser microscopy observations显示文摘BACKGROUND:Alpha-tocopherol(α-tocopherol) can effectively relieve neuronal damage induced by oxygen-centered free radicals.However,the effective dose remains controversial. OBJECTIVE:To evaluate the protective effects of low-concentrationα-tocopherol on neuronal membranes. DESIGN,TIME AND SETTING:Contrast observation and in vitro study,performed at Laboratory of Neurosurgery,Tianjin Huanhu Hospital between April and September 2006. MATERIALS:Fetal cortical neurons were derived from two 14-day pregnant SD rats,andα-tocopherol was provided by Sigma,USA. METHODS:The neurons were randomly assigned to six groups:(1) normal:neurons were cultured under normal conditions;(2) oxidative damage:oxidative free radicals was damaged using the Fenton reaction;(3)α-tocopherol:neurons were cultured in different concentrations ofα-tocopherol 10,20,40,and 80 mg/L for 2 hours,respectively. MAIN OUTCOME MEASURES:Neuronal membrane damage was observed using a confocal laser microscope,and malonaldehyde production was detected using the thiobarbituric acid method. RESULTS:At normal,biological concentrations(10 mg/L),α-tocopherol induced no change in the damaged neurons(P>0.05).However,at a concentration of 80 mg/L,the number of damaged neurons was significantly reduced,compared with the damage group(P<0.05). Malonaldehyde levels following 80 mg/Lα-tocopherol treatment were less than the oxygen free radical damage group(P<0.05),but greater than the control group(P<0.01). CONCLUSION:A concentration of 80 mg/Lα-tocopherol can effectively protect the neuronal Gel membrane from oxidative damage. | Weilun Liang Huiling Huang Qiaoli Wu Chen Wang Wenzhi Zhang Xin Su Dashi Zhi | 2009 | Neural Regeneration Research2009，4，2： | 0 |
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