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| 1 | Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes显示文摘As an excitatory transmitter system,the glutamatergic transmitter system controls excitability and conductivity of neurons.Since both cardiomyocytes and neurons are excitable cells,we hypothesized that cardiomyocytes may also be regulated by a similar system. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qiang Ji Qicheng Zou Lingling Wang Yi Liu Dandan Liang Jinfeng Xue Luxin Wang Xueting Gao Xingdong Gu Hongyu Liu r Xiaoyu He Li Li Jian Yang Youming Lu Luying Peng Yi-Han Chen | 2021 | Cell Research2021，31，9： | 5 |
| 2 | U Th dating of zircons from Holocene potassic and esites (Maanshan volca- no, Tengchong, SE Tibetan plateau) by depth profiling: time scales and nature of magma storage显示文摘 | Zou Haibo Fan Qicheng Axe1 K Schmitt | 2010 | Lithos2010，118，： | 1 |
| 3 | Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons显示文摘Activation of the heart normally begins in the sinoatrial node(SAN).Electrical impulses spontaneously released by SAN pacemaker cells(SANPCs)trigger the contraction of the heart.However,the cellular nature of SANPCs remains controversial.Here,we report that SANPCs exhibit glutamatergic neuron-like properties.By comparing the single-cell transcriptome of SANPCs with that of cells from primary visual cortex in mouse,we found that SANPCs co-clustered with cortical neurons.Tissue and cellular imaging confirmed that SANPCs contained key elements of glutamatergic neurotransmitter system,expressing genes encoding glutamate synthesis pathway(G/s),ionotropic and metabotropic glutamate receptors(Grina,Gria3,Grm1 and Grm5)t and glutamate transporters(Slc17a7).SANPCs highly expressed cell markers of glutamatergic neurons(Snap25 and S/-c17a7)t whereas Gad1,a marker of GABAergic neurons,was negative.Functional studies revealed that inhibition of glutamate receptors or transporters reduced spontaneous pacing frequency of isolated SAN tissues and spontaneous Ca2+transients frequency in single SANPC.Collectively,our work suggests that SANPCs share dominant biological properties with glutamatergic neurons,and the glutamatergic neurotransmitter system may act as an intrinsic regulation module of heart rhythm,which provides a potential intervention target for pacemaker cell-associated arrhythmias. | Dandan Liang Zhigang Xue Jinfeng Xue Duanyang Xie Ke Xiong Huixing Zhou Fulei Zhang Xuling Su Guanghua Wang Qicheng Zou Yi Liu Jian Yang Honghui Ma Luying Peng Chunyu Zeng Gang Li Li Wang Yi-Han Chen | 2021 | Protein & Cell2021，12，7： | 1 |
| 4 | Ion microprobe dating of zircons from active Dayingshan volcano, Tengchong, SE Tibetan Plateau: Time scales and nature of magma chamber storage显示文摘 | Tucker Ross T Zou Haibo Fan Qicheng | 2013 | Lithos2013，，172173： | 1 |
| 5 | Glutamate drives local Ca^(2+)release'in cardiac pacemaker cells显示文摘The sinoatrial node(SAN)is the origin of the electrical signals for rhythmic heartbeats in mammals.The spontaneous fring of SAN pacemaker cells(SANPCS)triggers cardiac contraction.'Local Ca^(2+)release'(LCR),a unique cellular activity,acts as the'engine'of the spontaneous fring of SANPCs.However,the mechanism of LCR initiation remains unclear.Here,we report that endogenous glutamate drives LCRs in SANPCs.Using a glutamate sensor,we unraveled a tight correlation between glutamate accumulation and LCR occurrence,indicating a potential relationship between glutamate and LCRs.Intracellular application of glutamate significantly enhanced the LCRs in both intact and permeabilized SANPCs.Mechanitically,we revealed that mitochondrial excitatory amino acid transporter 1(EAAT 1)-dependent mitochondrial glutamate import promoted ROS generation,which in turn led to the oxidation of Ca^(2+)-handling proteins,ultimately resulting in enhanced LCRs.Importantly,EAAT1 depletion reduced both the spontaneous fring rates of isolated SANPCs and the heart rate in vitro and in vivo,suggesting the central role of EAAT1 as a glutamate transporter in the regulation of cardiac autonomic rhythm.In conclusion,our results indicate that glutamate serves as an LCR igniter in SANPCs,adding a potentially important element to the coupled clock theory that explains the origin of spontaneous firing.These findings shed new light on the future prevention and treatment of cardiac pacemaker cell-related arrhythmias. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qicheng Zou Luxin Wang Caihong Zhang Yuting Cao Beihua Shao Yixin Zhang Peidong Zhang Dandan Liang Yi Liu Yi-Han Chen | 2022 | Cell Research2022，32，9： | 0 |
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