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| 1 | Risk factors and long-term health consequences of macrosomia:a prospective study in Jiangsu Province,China显示文摘We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group(24.35±3.14 years,P = 0.000).The mean maternal body mass index(BMI) at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group(21.76±2.59 kg/m 2,P = 0.000).About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group(P = 0.000).Compared with women with normal weight(BMI:18.5-23.9 kg/m 2),women who were overweight(BMI:24-27.9 kg/m 2) or obese(BMI ≥ 28 kg/m 2),respectively,had a 1.69-fold(P = 0.000) and a 1.49-fold(P = 0.000) increased risks of having a neonate with macrosomia,while light weight(BMI<18.5 kg/m 2) women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years(P = 0.001 and P = 0.000).Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. | Shouyong Gu Xiaofei An Liang Fang Xiaomin Zhang Chunyan Zhang Jingling Wang Qilan Liu Yanfang Zhang Yongyue Wei Zhibin Hu Feng Chen Hongbing Shen | 2012 | The Journal of Biomedical Research2012，26，4： | 14 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Separation and purification of water-soluble iridoid glucosides by high speed counter-current chromatography combined with macroporous resin column separation显示文摘 | Yue Huilan Zhao Xiaohui Wang Qilan | 2013 | J Chromatogr B2013，936，10： | 1 |
| 4 | Optimization of subcritical fluid extraction of seed oil from Nitraria tangutomm using response surface methodology显示文摘 | Liu Zenggen Mei Lijuan Wang Qilan | 2014 | LWT-Food Science and Technology2014，56，1： | 1 |
| 5 | 显示文摘 | Chen Yiwang Deng Qilan Xiao Jichun | 2007 | Polymer2007，48，： | 1 |
| 6 | Research on classification of e- mergency materials 显示文摘 | Dong Quanzhou Zhao Qilan | 2010 | Logistics System and Intelligent Man- agement2010，，2： | 1 |
| 7 | Optimiza- tion of subcritical fluid extraction of seed oil from Nitraria tanguorum using response surface methodology 显示文摘 | LIU Zenggen MEI Lijuan WANG Qilan | 2014 | LWT - Food Sci Technol2014，56，： | 1 |
| 8 | Fertilization and litter effects on the functional group biomass, species diversity of plants, microbial biomass, and enzyme activity of two alpine meadow communities显示文摘 | Changting Wang Ruijun Long Qilan Wang Wei Liu Zengchun Jing Li Zhang | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 9 | Research on Third Party Logistics Service Capability Maturity Model显示文摘 | Qiao Hongbo Zhao Qilan | 2008 | Service Operations and Logistics and Informaties IEEE International Conference2008，1215，： | 1 |
| 10 | Controlled grafting from poly (vinylidene fluoride ) microfiltration membranes via reverse atom transfer radical polymerization and antifouling properties 显示文摘 | CHEN Yiwang DENG Qilan XIAO Jichun | 2007 | Polymer2007，48，： | 1 |
| 11 | The Evaluation of Service Quality in Fast Food Industry显示文摘 | Yu Ding QiLan ZHAO Hongzhi LIU | 2007 | Service Systems and Service Management2007，6，1： | 1 |
| 12 | Research on Third Party Logistics Service Capability Maturity Model显示文摘 | Qiao Hongbo Zhao Qilan | 2008 | IEEE International Conference2008，，： | 1 |
| 13 | 显示文摘 | Chen Yiwang Liu Dongmei Deng Qilan | 2006 | Journal of Polymer Science: Part A: Polymer Chemistry2006，44，： | 1 |
| 14 | Optimization of subcritical fluid extraction of seed oil from Nitraria tangutorum using response surface methodology显示文摘 | Zenggen Liu Lijuan Mei Qilan Wang Yun Shao Yanduo Tao | 2014 | LWT - Food Science and Technology2014，，： | 1 |
| 15 | Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes显示文摘Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health,especially among immunocompromised populations.Given the intricate problem of dramatic increase in resistance to common biocides,the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding.In this study,Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine(ε-PL)decorated aldehyde functionalized mesoporous silica SBA-15(CHO-SBA-15)for the selective coordination of silver ions,which was affirmed by various physicochemical methods.Besides the identified broad-spectrum antibacterial activities,the as-prepared Schiff-base silver nanocomplex(CHO-SBA-15/ε-PL/Ag,CLA-1)exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates,SBA-15/ε-PL/Ag and CHO-SBA-15/Ag,respectively.In addition,CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver species.Significantly,CLA-1 kills Candida albicans cells,inhibits biofilm formation,and eliminates preformed biofilms,with no development of resistance during continuous serial passaging.The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species.In mouse models of multidrug-resistant C.albicans infection,CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs,amphotericin B and fluconazole.Moreover,CLA-1 treatment induces negligible toxicity against normal tissues with safety.Therefore,this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes. | Ling Cai Yanqiang Huang Yuanyuan Duan Qiao Liu Qilan Xu Jia Jia Jianming Wang Qian Tong Peipei Luo Yujie Wen Luming Peng Qian Wu Xudong Hang Huijun Jiang Ping Zhu Yanmei Yang Boshen Zhou Liping Zeng Hongkai Bi Jin Chen | 2021 | Nano Research2021，14，8： | 0 |
| 16 | GSH-responsive curcumin/doxorubicin encapsulated Bactrian camel serum albumin nanocomposites with synergistic effect against lung cancer cells显示文摘The aim of this study was to prepare camel serum albumin(CSA) nanoparticles using a self-assembly strategy to co-immobilize curcumin(CCM) and doxorubicin(Dox) which was in favor of combined chemotherapy and biomedical applications of bactrian(Camelus bactrianus) CSA. The constructed CSA nanoparticles(CSA-NPs)with the size around 200 nm displayed a high degree of polydispersity and further encapsulation of CCM and Dox caused no apparent morphological changes to the nanocomposite(CCM/Dox CSA-NPs). The synergistic cytotoxic effect of CCM and Dox on cancer cell A549 was observed with the calculated combination index less than 1.0. Moreover, the release kinetic profile of encapsulated drugs showed a concentration dependence of glutathione(GSH) originating from the GSH used in nanoparticle formation to break the intramolecular disulfide bonds. In vitro cytotoxicity evaluations also revealed that CCM/Dox CSA-NPs showed higher cytotoxicity than that of single drug loaded CSA-NPs, which was also validated by high content screen assay. Taken together, the CCM/Dox CSA-NPs with redox-responsive attributes provided an integrated protein-based combinational drugdelivery matrix to exert synergistic effects. | Xinyu Yu Adilijiang Xieripu Qilan Xu Azhati Zulipikaer Yiyan Song Ling Cai Jin Chen | 2020 | The Journal of Biomedical Research2020，34，1： | 0 |
| 17 | An Impact by the Leasing System of Urban Land upon Urban Development | Zou Deci China Academy of Urban Planning and Design Xie Qilan | 1993 | China City Planning Review1993，10，1： | 0 |
| 18 | Nursing Management During Public Health Emergencies显示文摘Public health emergencies are difficult to predict,have complex causes,and are extremely destructive.In order to reduce the impact of public health emergencies,this paper introduces a refined nursing management method to deal with public health emergencies.By establishing a sound management system,implementing scientific management processes,ensuring the overall quality of nursing,and improving the logistics,etc.,the cooperation between the medical staff can be improved,and the safety of personnel can be ensured. | Qilan Zhou | 2023 | Journal of Clinical and Nursing Research2023，7，3： | 0 |
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