| 1 | Reproducible and low-power multistate bio-memristor from interpenetrating network electrolyte design显示文摘Bio-memristor can address the inherent limitations of conventional memory components in artificial perceptual systems due to their biocompatibility with biological tissue.The actual deployment of bio-memristor is restricted by the lack of reproducibility,high power consumption,and insufficient storage capacity.Here,a reproducible and low-power multistate biomemristor is developed by designing the chitosan(CS)-reduced graphene oxide(rGO)interpenetrating network electrolyte.The interpenetrating network structure of the CS-rGO electrolyte reinforces structural stability and improves ionic conductivity.The bio-memristor equipped with CS-rGO active layer shows stable bipolar resistive switching up to 100 consecutive cycles,reproducible multistate storage with six different memory states,and low programming power of 9.4μW.The fabricated biocompatible CS-rGO device also exhibits deformation stability of memory operation over 103 bending cycles,high biocompatibility with HEK293 cells,and skin adhesion.This work provides an enlightening design strategy to develop highperformance bio-memristors for applications in artificial perceptual systems. | Bin Zhao Xuan Zhao QiLi Xiaochen Xun Tian Ouyang Zheng Zhang Zhuo Kang Qingliang Liao Yue Zhang | 2022 | InfoMat2022，4，11： | 0 |
| 2 | Novel insights into histone lysine methyltransferases in cancer therapy:From epigenetic regulation to selective drugs显示文摘The reversible and precise temporal and spatial regulation of histone lysine methyltransferases(KMTs)is essential for epigenome homeostasis.The dysregulation of KMTs is associated with tumor initiation,metastasis,chemoresistance,invasiveness,and the immune microenvironment.Therapeutically,their promising effects are being evaluated in diversified preclinical and clinical trials,demonstrating encouraging outcomes in multiple malignancies.In this review,we have updated recent understandings of KMTs'functions and the development of their targeted inhibitors.First,we provide an updated overview of the regulatory roles of several KMT activities in oncogenesis,tumor suppression,and immune regulation.In addition,we summarize the current targeting strategies in different cancer types and multiple ongoing clinical trials of combination therapies with KMT inhibitors.In summary,we endeavor to depict the regulation of KMT-mediated epigenetic landscape and provide potential epigenetic targets in the treatment of cancers. | Qili Liao Jie Yang Shengfang Ge Peiwei Chai Jiayan Fan Renbing Jia | 2023 | Journal of Pharmaceutical Analysis2023，13，2： | 0 |
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