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| 1 | Robust superhydrophobic polyurethane sponge functionalized with perfluorinated graphene oxide for efficient immiscible oil/water mixture, stable emulsion separation and crude oil dehydration显示文摘In recent years, graphene oxide(GO), prepared by the modified Hummers’ method, and its derivatives have become a focus of research owing to their outstanding physical and chemical properties and low cost. Drawing inspiration from the mussel protein,a facile and environmentally-friendly method was employed to fabricate superhydrophobic/superoleophilic reduced graphene oxide(rGO) derivative. The preparation comprises two steps: coating GO nanosheets with polydopamine(PDA) and subsequent reaction with 1H,1H,2H,2H-perfluorodecanethiol. Due to the excellent adhesive ability of PDA, the resulting f PDA modified rGO nanosheets(rGO-f PDA) were firmly immobilized onto polyurethane(PU) sponge skeleton by a simple drop-coating method. The as-prepared rGO-f PDA functionalized sponge exhibited superhydrophobic behavior with a water contact angle of 162°±2°, high organic adsorption capacity, recyclability and stable oil/water separation behavior under different acidic/alkaline conditions. Due to its facile fabrication technique and outstanding properties, the superhydrophobic-superoleophilic PU-rGOf PDA sponge holds great promise as an oil adsorbent for cleaning up large-scale pollution of oil and organic solvents, and dehydrating crude oil. | CAO Ning GUO JingYu BOUKHERROUB Rabah SHAO QingGuo ZANG XiaoBei LI Jin LIN XueQiang JU Hong LIU EnYang ZHOU ChaoFan LI HuiPing | 2019 | Science China(Technological Sciences)2019，62，9： | 6 |
| 2 | A unified study of continuous and discontinuous Galerkin methods显示文摘A unified study is presented in this paper for the design and analysis of different finite element methods(FEMs), including conforming and nonconforming FEMs, mixed FEMs, hybrid FEMs, discontinuous Galerkin(DG) methods, hybrid discontinuous Galerkin(HDG) methods and weak Galerkin(WG) methods.Both HDG and WG are shown to admit inf-sup conditions that hold uniformly with respect to both mesh and penalization parameters. In addition, by taking the limit of the stabilization parameters, a WG method is shown to converge to a mixed method whereas an HDG method is shown to converge to a primal method. Furthermore,a special class of DG methods, known as the mixed DG methods, is presented to fill a gap revealed in the unified framework. | Qingguo Hong Fei Wang Shuonan Wu Jinchao Xu | 2019 | Science China Mathematics2019，62，1： | 5 |
| 3 | A DISCONTINUOUS GALERKIN METHOD FOR THE FOURTH-ORDER CURL PROBLEM显示文摘在这篇论文,我们在场一个不连续的 Galerkin (DG ) 方法基于为解决在 3-dimensional 上从一个 magnetohydrodynamics 模型产生的一个第四顺序的卷屈方程的 Nedelec 有限元素空间围住 Lipschitz 多面体。我们证明方法为包含一个第四顺序的卷屈操作员的一个模型问题有最佳的错误估计。而且,在 2 种尺寸的一些数字结果被介绍验证理论结果。 | Qingguo Hong Jun Hu Shi Shu Jinchao Xu | 2012 | Journal of Computational Mathematics2012，30，6： | 2 |
| 4 | Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway显示文摘Cellular senescence is closely associated with age-related diseases.Ovarian aging,a special type of organ senescence,is the pathophysiological foundation of the diseases of the reproductive system.It is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells(HOSEpiCs).To contribute to the research on delaying ovarian aging,we aimed to investigate the novel epigenetic mechanism of melatonin in protecting HOSEpiCs.We discovered that melatonin has antagonistic effects against the oncogene-induced senescence(OIS)of HOSEpiCs.Mechanistically,the oncogene Ras decreased the expression of YTHDF2,which is the reader of RNA-m6A,by stimulating the generation of reactive oxygen species(ROS).Moreover,we found that the suppression of YTHDF2 increased the expression of MAP2K4 and MAP4K4 by enhancing the stability of the transcription of their mRNAs,thereby upregulating the expression of the senescence-associated secretory phenotype(SASP)through the activation of the MAP2K4 and MAP4K4-dependent nuclear factor-κB(NF-κB)signaling pathways.We further determined that melatonin has antagonistic effects against the OIS of HOSEpiCs by inhibiting the ROS-YTHDF2-MAPK-NF-κB pathway.These findings provide key insights into the potential avenues for preventing and treating ovarian aging. | Ruigong Zhu Xian Ji Xuan Wu Jiajing Chen Xuesong Li Hong Jiang Haiping Fu Hui Wang Zhe Lin Xin Tang Shixiu Sun Qingguo Li Bingjian Wang Hongshan Chen | 2022 | Genes & Diseases2022，9，2： | 2 |
| 5 | UNIFORM STABILITY AND ERROR ANALYSIS FOR SOME DISCONTINUOUS GALERKIN METHODS显示文摘In this paper,we provide a number of new estimates on the stability and convergence of both hybrid discontinuous Galerkin(HDG)and weak Galerkin(WG)methods.By using the standard Brezzi theory on mixed methods,we carefully define appropriate norms for the various discretization variables and then establish that the stability and error estimates hold uniformly with respect to stabilization and discretization parameters.As a result,by taking appropriate limit of the stabilization parameters,we show that the HDG method converges to a primal conforming method and the WG method converges to a mixed conforming method. | Qingguo Hong Jinchao Xu | 2021 | Journal of Computational Mathematics2021，39，2： | 1 |
| 6 | Correlation between eigenvalue spectra and dynamics of neural networks显示文摘 | Qingguo Zhou Tao Jin Hong Zhao | 2009 | Neural Computation2009，21，： | 1 |
| 7 | Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response显示文摘Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis,while the underlying mechanism remains elusive.Here,we report that the non-canonical stimulator of interferon genes(STING)-PKR-like ER kinase(PERK)pathway was significantly activated in both human and mice atherosclerotic arteries.Typically,STING activation leads to the activation of interferon regulatory factor 3(IRF3)and nuclear factor-kappa B(NF-κB)/p65,thereby facilitating IFN signals and infammation.In contrast,our study reveals the activated non-canonical STING-PERK pathway increases scaffold protein bromodomain protein 4(BRD4)expression,which encourages the formation of super-enhancers on the proximal promoter regions of the proinflammatory cytokines,thereby enabling the transactivation of these cytokines by integrating activated IRF3 and NF-κB via a condensation process.Endothelium-specific STING and BRD4 deficiency significantly decreased the plaque area and inflammation.Mechanistically,this pathway is triggered by leaked mitochondrial DNA(mtDNA)via mitochondrial permeability transition pore(mPTP),formed by voltage-dependent anion channel 1(VDAC1)oligomer interaction with oxidized mtDNA upon cholesterol oxidation stimulation.Especially,compared to macrophages,endothelial STING activation plays a more pronounced role in atherosclerosis.We propose a non-canonical STING-PERK pathway-dependent epigenetic paradigm in atherosclerosis that integrates IRF3,NF-κB and BRD4 in inflammatory responses,which provides emerging therapeutic modalities for vascular endothelial dysfunction. | Xuesong Li Xiang Chen Longbin Zheng Minghong Chen Yunjia Zhang Ruigong Zhu Jiajing Chen Jiaming Gu Quanwen Yin Hong Jiang Xuan Wu Xian Ji Xin Tang Mengdie Dong Qingguo Li Yuanqing Gao Hongshan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 1 |
| 8 | Preparation of a gene-engineering mutant of bacteriorhodopsin BR-D96V and corresponding poly(vinyl alcohol)-based functional composite films显示文摘Bacteriorhodopsin(BR)exhibits,as a membrane protein in Halobacterium salinarum,unique photoresponsive behaviors,and shows promise as a functional information material.A new mutant of BR with the 96th aspartic acid replaced by valine(BR-D96V)was obtained and then a composite film of BR-D96V in a synthetic polymer matrix was prepared in this research.The mutant BR-D96V was expressed in a bacterio-opsin deficient halobacterial strain(L33)by gene engineering.Although valine is very hydrophobic,this point mutant keeps the basic biological activities,namely,photoelectric and photochromic responses.Nevertheless,the lifetime of M intermediate in the BR mutant is nearly two orders of magnitude longer than that of wild-type BR in neutral aqueous solution,which benefits its potential application as an information material.The M lifetime is further significantly prolonged after embedding BR-D96V into poly(vinyl alcohol)(PVA).It was also found that BR-D96V is very sensitive to water content in comparison with wild-type BR and another BR mutant. | ZHAO YingChun MING Ming HONG Jie MA DeWang WU Jia LI QingGuo HUANG WeiDa DING JianDong | 2010 | Chinese Science Bulletin2010，55，33： | 1 |
| 9 | An extended Galerkin analysis for elliptic problems显示文摘A general analysis framework is presented in this paper for many different types of finite element methods(including various discontinuous Galerkin methods).For the second-order elliptic equation-div(α▽u)=f,this framework employs four different discretization variables,u_(h),p_(h),u_(h)and p_(h),where u_(h)and p_(h)are for approximation of u and p=-α▽u inside each element,and u_(h)and p_(h)are for approximation of the residual of u and p·n on the boundary of each element.The resulting 4-field discretization is proved to satisfy two types of inf-sup conditions that are uniform with respect to all discretization and penalization parameters.As a result,many existing finite element and discontinuous Galerkin methods can be analyzed using this general framework by making appropriate choices of discretization spaces and penalization parameters. | Qingguo Hong Shuonan Wu Jinchao Xu | 2021 | Science China Mathematics2021，64，9： | 0 |
| 10 | Effect of potential difference between nano-Al_(2)O_(3)whisker and Mg matrix on the dispersion of Mg composites显示文摘The potential difference between positive and negative ions was utilized to improve the homogenized dispersion of nanoscale Al_(2)O_(3) whiskers in Mg matrix composites.The Mg powders were decorated with sodium dodecylbenzene sulfonate(C_(18)H_(29)NaO_(3)S,SDBS)and were introduced to the cathode group on their surface.The Al_(2)O_(3) whiskers were modified by the cetyl trimethyl ammonium bromide(C_(19)H_(42)BrN,CTAB)and were featured in the anode group.The suitable contents of CTAB and SDBS,the application atmosphere,and the type of solvents were investigated.Dispersion results showed that adding 2wt%SDBS into Mg powders and adding 2wt%CTAB into Al_(2)O_(3) whiskers pro-moted the formation of more uniformly mixed composite powders,compared to those of conventional ball milling via scanning electron micro-scopy(SEM)analysis.Meanwhile,the calculated results derived from first-principle calculations also demonstrated the stronger cohesion between Al_(2)O_(3) whisker reinforcements and Mg matrix than undecorated composite powders.After preparation by powder metallurgy,the mor-phology,grain size,hardness,and standard deviation coefficient of composites were analyzed to evaluate the dispersed efficiency.The results indicated that the modification of homogenized dispersed Al_(2)O_(3) whiskers in composites contributed to the refinement of 26%in grain size and the improvement of 20%in hardness compared with pure Mg,and the reduction of 32.5%in the standard deviation coefficient of hardness compared with the ball-milling sample. | Xiaoying Qian Hong Yang Chunfeng Hu Ying Zeng Yuanding Huang Xin Shang Yangjie Wan Bin Jiang Qingguo Feng | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，1： | 0 |
| 11 | 本刊英文版2019年62卷第1期摘要(英文)显示文摘A unified study of continuous and discontinuous Galerkin methods Qingguo Hong,Fei Wang,Shuonan Wu &Jinchao Xu Abstract A unified study is presented in this paper for the design and analysis of different finite element methods (FEMs),including conforming and nonconforming FEMs,mixed FEMs,hybrid FEMs,discontinuous Galerkin (DG)methods,hybrid discontinuous Galerkin (HDG)methods and weak Galerkin (WG)methods.Both HDG and WG are shown to admit inf-sup conditions that hold uniformly with respect to both mesh and penalization parameters.In addition,by taking the limit of the stabilization parameters,a WG method is shown to converge to a mixed method whereas an HDG method is shown to converge to a primal method.Furthermore,a special class of DG methods,known as the mixed DG methods,is presented to fill a gap revealed in the unified framework. | Qingguo Hong Fei Wang Shuonan Wu Jinchao Xu | 2019 | 中国科学:数学2019，49，1： | 0 |
| 12 | Mahuang Xixin Fuzi decoction protects against ovalbumin-induced allergic rhinitis by inhibiting type 2 innate lymphoid cells in mice显示文摘Objective:As a traditional herbal formula,Mahuang Xixin Fuzi decoction(MXFD)has been used to treat allergic rhinitis(AR).It regulates the transcription factor GATA3 in T cells,blocks Th2 skewing and rebalances the Th1/Th2 immunity.Type 2 innate lymphoid cells(ILC2s)are closely associated with GATA3.However,it remains unknown whether ILC2s could be one mechanism through which MXFD acts.We sought to elucidate the efficacy and mechanism of action of this decoction in AR treatment.Methods:Forty C57BL/6J female mice were equally divided into control,model,loratadine-and MXFDtreated groups in random.AR was induced by ovalbumin(OVA),and then treatment with loratadine or MXFD was administered.AR scores were evaluated and compared before and after treatment.Pathological changes in the nasal mucosa and lung were observed using hematoxylin-eosin staining of tissue samples.Activation of ILC2 in nasal mucosa was assessed by immunofluorescence and quantitative polymerase chain reaction analysis.ILC2 cell count in lungs was measured by flow cytometry and levels of interleukin-(IL)4,IL-5 and IL-13 in serum were detected by ELISA.Results:The decoction alleviated the symptoms of AR in mice,improved vascular congestion and expansion,glandular hyperplasia and inflammatory cell infiltration in mouse nasal mucosa and slowly improved the interstitial pneumonia and lesions.Meanwhile,MXFD reduced the number and percentage of ILC2s in the nasal mucosa and lungs,downregulated the expression of GATA3 mRNA and RORa mRNA,and reduced the related inflammatory cytokine levels,including IL-4,IL-5 and IL-13.Conclusion:These data suggest that inhibition of ILC2s by MXFD may be an important means by which to treat AR. | Hong Ren Wenting Ji Xue Yu Dongyu Ge Ruijuan Dong Qingguo Wang Min Liu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，4： | 0 |
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