3篇
您的检索式：作者名="Qinghong Sheng"
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| 1 | Synthesis of La^3+ doped mesoporous titania with highly crystallized walls显示文摘 | Yuan Shuai Sheng Qiaorong Zhang Jinlong Chen Feng Anpo Masakazu Zhang Qinghong | 2005 | Microporous and Mesoporous Materials2005，，79： | 1 |
| 2 | USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ显示文摘The balance between inflammatory T helper type 17(Th17)and immunosuppressive regulatory T(Treg)cells is critical for maintaining immune homeostasis in the human body and is tightly regulated under healthy conditions.An increasing number of studies have reported that deubiquitinases(DUBs)play a vital role in regulating Th17-and Treg-cell differentiation.However,the biological functions of only a small fraction of DUBs in Th17-and Treg-cell differentiation are well defined.In this study,we identified ubiquitin-specific peptidase 1(USP1)as a vital regulator of CD4+T-cell differentiation.USP1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation,thereby promoting the development of inflammatory diseases.Mechanistically,USP1 in CD4+T cells enhanced the activity of RORγt but promoted the proteasomal degradation of Foxp3 through deubiquitination and stabilization of TAZ in vitro and in vivo.Notably,ML323,a specific inhibitor of the USP1/UAF1 deubiquitinase complex,inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo,indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg cells.Our study highlights the critical role of USP1 in regulating adaptive immune responses and suggests that USP1 might be a drug target for the treatment of diseases associated with an imbalance between Th17 and Treg cells. | Xiaotong Zhu Peng Wang Xiaoxia Zhan Yuping Zhang Junli Sheng Shitong He Yitian Chen Dingnai Nie Xiaolong You Haiyan Mai Qinghong Yu Laisheng Li Ligang Jie Shengfeng Hu | 2023 | Cellular & Molecular Immunology2023，20，3： | 0 |
| 3 | The Effect of Martian Ionospheric Dispersion on SAR Imaging显示文摘When passing through the ionosphere,the high-frequency(HF)pulse signal of the Mars Exploration Radar is affected by the dispersion effect error,which results in signal attenuation and time delay and brings about a phase advance in such a way that the echo cannot be matched and filtered.In this paper,a high-order phase model is built to overcome the above problems and enable echo matching and filtering.Most studies on the dispersion effect approximate the additional phase after the effect,assuming that the ionosphere is a thin-layer structure.In this paper,an effective model for the HF waveband is constructed to analyze the change of signal propagation paths in the ionosphere.The additional phase is expanded in a Taylor series and retained these expansions as high-order terms to calculate the cumulative additional phase along the path.We show the rangeoffset variables of signal frequency,bandwidth,and electron density,simulate the effects of the ionosphere under different conditions,and conclude that the model can effectively estimate Mars without considering the effects of magnetic fields and anomalous solar activity and the effect of the ionosphere on synthetic aperture radar(SAR)echoes.The results obtained using ray tracing calculations are different from those obtained by simplifying assumptions,and we can simulate the Martian ionospheric effects by the former. | Bo Wang Xijin Luo Qinghong Sheng Zhijun Yan | 2022 | Space(Science & Technology)2022，，1： | 0 |
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