4篇
您的检索式：作者名="Qingling An"
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| 1 | δ 18O values of tree rings as a proxy of monsoon precipitation in arid Northwest China 显示文摘 | Liu Weiguo Feng Xiahong Liu Yu Zhang Qingle An Zhisheng | 2004 | Chem Geol2004，206，12： | 1 |
| 2 | Establishment of organoid models for pancreatic ductal adenocarcinoma and screening of individualized therapy strategy显示文摘Background:Patients with pancreatic ductal adenocarcinoma(PDAC)who undergo surgical resection and receive effective chemotherapy have the best chance for longterm survival.Unfortunately,because of the heterogeneity of pancreatic cancer,it is difficult to find a personalized treatment strategy for patients.Organoids are ideal preclinical models for personalized medicine.Therefore,we explore the cultivation conditions and construction methods of PDAC organoid models to screen the individualized therapy strategy.Methods:Fresh PDAC tissues from surgical resection were collected and digested with digestive enzymes;then the tumor cells were embedded in Matrigel with a suitable medium to establish the PDAC organoid models.The genetic stability of the organoids was analyzed using whole exon sequencing;hematoxylin and eosin staining and immunohistochemistry of organoids were performed to analyze their consistency with the pathological morphology of the patient's tumor tissue;After 2 days of organoid culture,we selected four commonly used clinical chemotherapy drugs for single or combined treatment to analyze drug sensitivity.Results:Two cases of PDAC organoid models were successfully established,and the results of their pathological characteristics and exome sequencing were consistent with those of the patient's tumor tissue.Both PDAC organoids showed more sensitivity to gemcitabine and cisplatin,and the combined treatment was more effective than monotherapy.Conclusion:Both organoids better retained the pathological characteristics,genomic stability,and heterogeneity with the original tumor.Individual PDAC organoids exhibited different sensitivities to the same drugs.Thus,this study provided ideal experimental models for screening individualized therapy strategy for patients with PDAC. | Miaomiao Gong Han Meng Dengxu Tan Peng Li Jing Qin Qingling An Changhong Shi Jiaze An | 2023 | Animal Models and Experimental Medicine2023，6，5： | 0 |
| 3 | Observer-based passive control for descriptor systems with time-delay显示文摘This article is concerned with the problem of observer-based passive control for descriptor systems with time delay. Suffcient conditions are first presented for the closed loop systems to be admissible and passive with dissipation η in the case of that the time delay is known, and two kinds of methods are given to design the expected observer. Then, the case of that the time delay is unknown or uncertain is discussed. The observer-based control gains could be obtained from the solutions of linear matrix inequalities (LMIs). Simulation examples are given to show the effectiveness of the designed methods. | Li Qin Zhang Qingling Zhang Yanjuan An Yichun | 2009 | Journal of Systems Engineering and Electronics2009，20，1： | 0 |
| 4 | Singularly perturbed bifurcation subsystem and its application in power systems显示文摘The singularly perturbed bifurcation subsystem is described,and the test conditions of subsystem persistence are deduced.By use of fast and slow reduced subsystem model,the result does not require performing nonlinear transformation.Moreover,it is shown and proved that the persistence of the periodic orbits for Hopf bifurcation in the reduced model through center manifold.Van der Pol oscillator circuit is given to illustrate the persistence of bifurcation subsystems with the full dynamic system. | An Yichun Zhang Qingling Zhu Yukun Zhang Yan | 2008 | Journal of Systems Engineering and Electronics2008，19，4： | 0 |
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