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| 1 | The application and efficacy of stent place for Budd-Chiari syndrome显示文摘Objective To evaluate the application value and efficacy on stent place for Budd-Chiari syndrome(BCS). Methods From January 1990 to May 2017, 2228 patients with BCS were admitted to our institution. The mean age was 43.3 years. Stents were placed in inferior vena cava(IVC), hepatic vein(HV), or both after balloon dilation. During follow-up period, the patency of stent was evaluated by ultrasound regularly and the clinic sign was surveyed by letter, telephone or clinic visit. The restenosis of stent were treated with balloon dilatation and thrombolysis to restore the its function. Results IVC type was diagnosed in 1492 cases, HV type in 510 cases, and mixed type in 226 cases. Eighteen patients aborted treatment because of economic reasons, advanced liver cancer, severe scoliosis, or both bilateral iliac veins and total IVC occlusion. Among the other 2210 cases who underwent endovascular therapy, stents were implanted into IVC in 339 cases, HV in 97 cases, mixed type in 64 cases. The rate of restenosis in IVC stent was 11.50%(39/339). After repeat angioplasty, the long-term patency rate reached to 98.12%. The incidence of HV occlusion caused by IVC stent was 12.09%(n = 41). Restenosis occurred in 47 cases(48.45%) after HV stent placement. However, the 5-year patency rate was 91.75%(89/97) after repeat dilatation and stent re-implantation. The incidence of IVC obstruction caused by HV was 3.33%(3 cases). Conclusion IVC stent placement appears to be an effective treatment for the cases of IVC segmental occlusion, and at the same time, the stent has the dual role of compression and fixation of thrombus and support of lumen. The HV and accessory hepatic vein obstruction could happen when the IVC stent crossed these veins ostium. The incidence of the stent restenosis in the HV was higher than that in the IVC. | Maoheng Zu Hao Xu Yuming Gu Qingqiao Zhang Ning Wei Wei Xu Yanfeng Cui | 2018 | Journal of Interventional Medicine2018，1，3： | 7 |
| 2 | Expression of transforming growth factor-α and hepatitis B surface antigen in human hepatocellular carcinoma tissues and its significance显示文摘AIM:To evaluate the expression of transforming growthfactor-alpha (TGF-α) and hepatitis B surface antigen (HBsAg) in human hepatocellular carcinoma (HCC) tissues and its significance.METHODS:Seventy specimens of HCC tissues were detected by immunohistochemical method. Five specimens of normal human liver tissues were used as control.RESULTS: The TGF-o~ positive expression rates in HCC and its surrounding tissues were 74.3%(52/70) and 88.1%(52/59), respectively. TGF-α positive granules were mainly in the cytoplasm and fewer existed on the karyotheca. The TGF-α positive expressing rate in well differentiated HCC was significantly higher than that in moderately and poorly differentiated HCC (P<0.05).The TGF-α positive expression also was observed in intrahepatic bile ducts (part of those were hyperplastic ducts).The HBsAg positive expression rates in HCC and its surrounding tissues were 21.4%(15/70) and 79.7%(47/59), respectively.HBsAg positive granules were in the cytoplasm, inclusion and on the karyotheca.There was a prominent positive correlation between TGF-α and HBsAg expression in HCC surrounding tissues (P<0.05,γ=0.34). TGF-α was usually existed with HBsAg in regenerated and/or dysplastic liver cells.In the five normal liver tissues, TGF-α and HBsAg were not detectable in hepatocytes and bile ducts.CONCLUSION:Hepatitis B virus infection is dosely related with hepatocarcinogenesis.The overexpression of TGF-α in the liver seems to be associated with the regeneration of hepatocytes injured by HBsAg.The continued expression of TGF-α might lead to dysplasia of liver cells and development of HCC. Furthermore, TGF-α might play a role in morphogenesis and regeneration of intrahepatic bile ducts. | JingZhang Wen-LiangWang QingLi QingQiao | 2004 | World Journal of Gastroenterology2004，10，6： | 6 |
| 3 | Directed assembly of one-dimensional nanostructures into functional networks 显示文摘 | Huang Yu Duan Xiangfeng Wei Qingqiao | 2001 | Science2001，291，5504： | 1 |
| 4 | Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species显示文摘 | Cui Yi Wei Qingqiao Park Hongkun | 2001 | Science2001，293，5533： | 1 |
| 5 | Efficiency and application of poly(acryldinitrophenylamidrazone-dinitroacrylphenylhydrazine) chelating fiber for pre-concentrating and separating trace Au(III), Ru(III), In(III), Bi(III), Zr(IV), V(V), Ga(III) and Ti(IV) from solution samples显示文摘 | Xijun Chang Qingqiao Su Dongying Liang Xinjie Wei Bingtao Wang | 2002 | Talanta2002，，2： | 1 |
| 6 | Nanowirenanosensors for highly sensitive and selective detection ofbiological and chemical species 显示文摘 | Cui Yi Wei Qingqiao Park Hongkun | 2001 | Science2001，293，5533： | 1 |
| 7 | Directed Assembly of One - Dimensional Nanostructures into Functional Networks显示文摘 | Xiangfeng Duan Qingqiao Wei | 2001 | Science2001，291，： | 1 |
| 8 | Directed Assembly of one-Dimensional Nanostructures into Functional Networks显示文摘 | HUANG Yu DUAN Xiangfeng WEI Qingqiao | 2001 | Science2001，291，： | 1 |
| 9 | Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species显示文摘 | Cui Yi Wei Qingqiao Park Hongkun | 2001 | Science2001，293，5533： | 1 |
| 10 | Di- rected assembly of one-dimensional nanostructures into functional networks 显示文摘 | Huang Yu Duan Xiangfeng Wei Qingqiao | 2001 | Science2001，291，： | 1 |
| 11 | Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species显示文摘 | Wei Qingqiao Park H K | 2001 | Science2001，293，： | 1 |
| 12 | Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species显示文摘 | Cui Yi Wei Qingqiao Park Hongkun | 2001 | Science2001，293，5533： | 1 |
| 13 | Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species显示文摘 | CuiYi Wei Qingqiao Park H | 2001 | Science2001，293，5533： | 1 |
| 14 | Directed assembly of one-dimensional nanostructures into functional networks显示文摘 | HUANG Yu DUAN Xiangfeng WEI Qingqiao | 2001 | Science2001，291，5504： | 1 |
| 15 | 显示文摘 | Cui Yi Wei Qingqiao Hongkun Park | 2001 | Science2001，293，5533： | 1 |
| 16 | Directed assembly of one-dimensional nanostructures into functional networks显示文摘 | Yu Huang Duan Xiangfeng Wei Qingqiao | 2001 | Science2001，，291： | 1 |
| 17 | Primary targeting of recombinant Fv-immunotoxin hscFv_(25)-mTNFα against hepatocellular carcinoma显示文摘AIM: To obtain human recombinant Fv-immunotoxin hscFv25-mTNFα (mutant human TNFαfused to human scFv25) against hepatocellular carcinoma (HCC).METHODS: Two relevant sites of enzymatic digestion were added to mTNFα by PCR. mTNFα was linked to the 3' end of hscFv25 in pGEX4T-1 vector. This anti-HCC recombinant Fv-immunotoxin hscFv25-mTNFα was expressed in Escherichia coliand purified from inclusions. After purified by glutathione-S-transferase affinity chromatography and thrombin digestion, it was identified by electrophoresis and Western blot. And then, the purified recombinant Fvimmunotoxin was injected into nude mice with HCC xenografts through their tail veins, mTNFα protein and PBS were used as control at the same time. After treated for two weeks, nude mice were executed. The bulk and weight of tumors were observed. The tumor tissues were stained by immunohistochemical method with TNFα antibody.RESULTS: The expression ratio of recombinant Fv-immunotoxin hscFv25-mTNFα was 12% of bacterial protein. The result of tumor restraining trials of hscFv25-mTNFα showed 2/5 complete remission and 3/5 partial remission, mTNFα restraining trials showed 5/5 partial remission. The therapeutic result of hscFv25-mTNFα was better than that of mTNFα (F=8.70, P | JingZhang Yan-FangLiu Shou-JingYang QingQiao HongCheng Chuan-ShanZhang Fu-ChengMa Hua-ZhangGuo | 2004 | World Journal of Gastroenterology2004，10，13： | 1 |
| 18 | Graphene controlled phase evolution in Sr-deficient Sr(Ti, Nb)O_(3) thermoelectric ceramics显示文摘Correlated phase and microstructural evolution are systematically investigated by electron microscopies in Sr-deficient Sr(Ti,Nb)O_(3)(STNO)thermoelectric ceramics incorporated with different fraction of reduced graphene oxide(RGO).It is found that while no impurity except for very few Ti_(3)O_(5) precipitates are observed in monolithic STNO,the Nb-enriched rutile TiO_(2) appears in RGO/STNO composites.With increasing RGO content,the amount of precipitates increase at first and then decrease when RGO content becomes high,which can be ascribed to the formation of local Magneli phase.In addition,the energy-dispersive X-ray spectra combined with cathodoluminescence characterization indicates that the variation of Sr deficiency experiences the opposite trend with respect to the precipitates content.These findings clearly reveal the unique reducing effect of RGO on the microstructure of doped SrTiO_(3) with Sr deficiency,which can greatly facilitate the design of perovskite based thermoelectric materials of hierarchical structure. | Jia Li Cao Wu Jilong Huang Juanjuan Xing Yuchi Fan Qingqiao Fu Ying Jiang Hui Gu | 2021 | Journal of Materiomics2021，7，2： | 0 |
| 19 | Staged-probability strategy of processing shotgun proteomic data to discover more functionally important proteins显示文摘Biologically important proteins related to membrane receptors,signal transduction,regulation,transcription,and translation are usually low in abundance and identified with low probability in mass spectroscopy(MS)-based analyses.Most valuable proteomics information on them were hitherto discarded due to the application of excessively strict data filtering for accurate identification.In this study,we present a stagedprobability strategy for assessing proteomic data for potential functionally important protein clues.MS-based protein identifications from the second(L2)and third(L3)layers of the cascade affinity fractionation using the Trans-Proteomic Pipeline software were classified into three probability stages as 1.00–0.95,0.95–0.50,and 0.50–0.20 according to their distinctive identification correctness rates(i.e.100%–95%,95%–50%,and 50%–20%,respectively).We found large data volumes and more functionally important proteins located at the previously unacceptable lower probability stages of 0.95–0.50 and 0.50–0.20 with acceptable correctness rate.More importantly,low probability proteins in L2 were verified to exist in L3.Together with some MS spectrogram examples,comparisons of protein identifications of L2 and L3 demonstrated that the stagedprobability strategy could more adequately present both quantity and quality of proteomic information,especially for researches involving biomarker discovery and novel therapeutic target screening. | Hong Xu Guijun Ma Qingqiao Tan Qiang Zhou Wen Su Rongxiu Li | 2012 | Protein & Cell2012，3，2： | 0 |
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