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| 1 | NMDA Receptor Antagonist MK801 Protects Against 1-Bromopropane-Induced Cognitive Dysfunction显示文摘Occupational exposure to 1-bromopropane(1-BP) induces learning and memory deficits. However, no therapeutic strategies are currently available. Accumulating evidence has suggested that N-methyl-D-aspartate receptors(NMDARs) and neuroinflammation are involved in the cognitive impairments in neurodegenerative diseases. In this study we aimed to investigate whether the noncompetitive NMDAR antagonist MK801 protects against 1-BPinduced cognitive dysfunction. Male Wistar rats were administered with MK801(0.1 mg/kg) prior to 1-BP intoxication(800 mg/kg). Their cognitive performance was evaluated by the Morris water maze test. The brains of rats were dissected for biochemical, neuropathological,and immunological analyses. We found that the spatial learning and memory were significantly impaired in the1-BP group, and this was associated with neurodegeneration in both the hippocampus(especially CA1 and CA3)and cortex. Besides, the protein levels of phosphorylated NMDARs were increased after 1-BP exposure. MK801 ameliorated the 1-BP-induced cognitive impairments and degeneration of neurons in the hippocampus and cortex.Mechanistically, MK801 abrogated the 1-BP-induced disruption of excitatory and inhibitory amino-acid balance and NMDAR abnormalities. Subsequently, MK801 inhibited the microglial activation and release of pro-inflammatory cytokines in 1-BP-treated rats. Our findings, for the first time, revealed that MK801 protected against 1-BP-induced cognitive dysfunction by ameliorating NMDAR function and blocking microglial activation, which might provide a potential target for the treatment of 1-BP poisoning. | Lin Xu Xiaofei Qiu Shuo Wang Qingshan Wang Xiu-Lan Zhao | 2019 | Neuroscience Bulletin2019，35，2： | 8 |
| 2 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 3 | HER4 promotes the growth and metastasis of osteosarcoma via the PI3K/AKT pathway显示文摘Osteosarcoma is the most common primary malignant bone tumor,which occurs in adolescents.As reported by our previous studies,HER4 indicates a poor prognosis of primary osteosarcoma.However,its mechanisms in the pathogenesis of osteosarcoma have not yet been studied.The purpose of this study was to investigate the role of HER4 in osteosarcoma and whether the PI3K/AKT pathway is involved.In this study,western blot analysis was used to investigate the expression of HER4 protein in osteosarcoma tissues and cell lines.CCK8 and transwell assays were used to detect the effects of HER4 on the proliferation,migration,and invasion of osteosarcoma cells in vitro.The effects of HER4 on the growth and metastasis of osteosarcoma in vivo were detected by tumor formation and immunofluorescence in nude mice.The role of the PI3K/AKT pathway in HER4 regulation of the growth and metastasis of osteosarcoma was examined by western blot analysis and immunofluorescence assay.We found that HER4 protein was highly expressed in clinical osteosarcoma specimens and osteosarcoma cells.HER4 markedly promoted the proliferation,migration,and invasion of osteosarcoma cells in vitro as well as the growth and metastasis of osteosarcoma in vivo.HER4 overexpression upregulated the expression of phosphorylated protein kinase B(pAKT),proliferation marker antigen Ki67,and metastasis cell marker matrix metalloproteinase 9(MMP9).Notably,PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT,Ki67,and MMP9.Moreover,LY294002 markedly blocked the effects of HER4-induced upregulation of tum or malignancy.The present study suggests that HER4 may promote the growth and metastasis of osteosarcoma via the PI3K/AKT pathway.The HER4/PI3K/AKT pathway could serve as a potential target for the treatment of osteosarcoma. | Xiaodong Li Qingshan Huang Shenglin Wang Zhen Huang Fengqiang Yu Jianhua Lin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 3 |
| 4 | An exploratory study of three-dimensional MP-PIC-based simulation of bubbling fluidized beds with and without baffles显示文摘 | Shuai Yang Hao Wu Weigang Lin Hongzhong Li Qingshan Zhua | 2018 | Particuology2018，16，4： | 3 |
| 5 | A Personalized Search Model Using Online Social Network Data Based on a Holonic Multiagent System显示文摘Personalized search utilizes user preferences to optimize search results,and most existing studies obtain user preferences by analyzing user behaviors in search engines that provide click-through data.However,the behavioral data are noisy because users often clicked some irrelevant documents to find their required information,and the new user cold start issue represents a serious problem,greatly reducing the performance of personalized search.This paper attempts to utilize online social network data to obtain user preferences that can be used to personalize search results,mine the knowledge of user interests,user influence and user relationships from online social networks,and use this knowledge to optimize the results returned by search engines.The proposed model is based on a holonic multiagent system that improves the adaptability and scalability of the model.The experimental results show that utilizing online social network data to implement personalized search is feasible and that online social network data are significant for personalized search. | Meijia Wang Qingshan Li Yishuai Lin | 2020 | China Communications2020，17，2： | 2 |
| 6 | Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents显示文摘 | Wanyi Zhao Xiue Feng Shurong Ban Wenhan Lin Qingshan Li | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，14： | 1 |
| 7 | Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents显示文摘 | Wanyi Zhao Xiue Feng Shurong Ban Wenhan Lin Qingshan Li | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，14： | 1 |
| 8 | Reservoir Characteristics of Fine-grained Sedimentary Rocks in Saline Lakes in the Cenozoic Upper Ganchaigou Formation,Southwestern Qaidam Basin,NW China显示文摘Cenozoic fine-grained sedimentary rocks in the southwestern Qaidam Basin,as typical salinized lacustrine sediments,are significantly different from those in other freshwater lakes under the impact of the high salinity in the lake.Many fine-grained sedimentary rock samples were selected from the lower member of Neogene(N_(1))in the Gaskule Oilfield,Qaidam Basin,northwest China,with the aim to analyze and test their petrology,pore structure,and organic geochemical characteristics and determine its genesis and geological significance.Based on previous results,a new genesis of mixed sedimentary rocks is proposed.The Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin belong to mixed sedimentary rocks,which can be divided into three types,including carbonate and terrigenous clastic-bearing mudstone,carbonate-bearing to terrigenous clastic mixed sedimentary rocks,and carbonate-terrigenous clastic mixed sedimentary rocks.The geneses of mixing are quite different from that of mixed marine rocks.According to the sedimentary characteristics of the salinized lakes,three new geneses of mixed deposits are proposed:syn-sedimentary mixing,varve interbedded mixing,and biogenic mixing.The reservoir spaces of the Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin include residual intergranular pores,intercrystalline pores,microfractures,and minor dissolved pores.The reservoirs have super-low porosity and ultra-low permeability,with a porosity of 1.82%-21.04%,averaging 7.71%,and permeability of(0.0028-254.86)×10^(−3)μm^(2),averaging 2.82×10^(−3)μm^(2).The test results of total organic carbon(TOC)content show that the highest content of organic carbon reached 1.41%,and those of vitrinite reflectance show that Ro ranges from 0.525%-0.824%,with an average of 0.806%.The organic geochemical characteristics show that the fine-grained mixed sedimentary rocks of SW Qaidam Basin have the potential for self-generation and self-storage.As an unconventional reservoir,it has potential industrial value.This is the first study of fine-grained sedimentary rocks in the Qaidam Basin,which offers certain theoretical and practical values. | SHENG Jun LIU Jincheng LI Yunlong ZOU Haiyan LONG Anlin WANG Lin LI Jiyong QI Qingshan YANG Xiaojing LI Yanan | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 1 |
| 9 | Comparison of genetic impact on growth and wood traits between seedlings and clones from the same plus trees of Pinus koraiensis显示文摘To evaluate the relationships among clones and open pollinated families from the same plus trees and to select elite breeding materials,growth,and wood characteristics of 33-year-old Pinus korainsis clones and families were measured and analyzed.The results show that growth and wood characters varied significantly.The variation due to clonal effects was higher than that of family effects.The ratio of genetic to phenotypic coefficient of variation of clones in growth and wood traits was above 90%,and the repeatability of these characteristics was more than 0.8,whereas the ratio of genetic to phenotypic coefficient of variation of families was above 90%.The broad-sense heritability of all characteristics exceeded 0.4,and the narrow-sense family heritability of growth traits was less than 0.3.Growth characteristics were positively correlated with each other,but most wood properties were weakly correlated in both clones and families.Fiber length and width were positively correlated between clones and families.Using the membership function method,eleven clones and four families were selected as superior material for improved diameter growth and wood production,and two families from clonal and open-pollinated trees showed consistently better performance.Generally,selection of the best clones is an effective alternative to deployment of families as the repeatability estimates from clonal trees were higher than narrow-sense heritability estimates from open pollinated families.The results provide valuable insight for improving P.koraiensis breeding programs and subsequent genetic improvement. | Xiaoting Liu Zhimin Lu Jingui Wu Yuchun Yang Shuchun Li Lin Wu Qingshan Xu Qi Yu Li Zhao Jian Sun Wei Zheng Mulualem Tigabu Xiyang Zhao | 2023 | Journal of Forestry Research2023，34，2： | 0 |
| 10 | Rab蛋白家族的蛋白相互作用组研究揭示树突状细胞Rab32蛋白复合体防御细菌感染机制显示文摘树突状细胞发挥功能依赖胞内广泛存在的Rab蛋白介导的复杂膜转运系统。 | Yuanyuan Li Yu Wang Liyun Zou Xiangyu Tang Yi Yang Li Ma Qingzhu Jia Qingshan Ni Siqi Liu Lizhang Tang Regina Lin Elizabeth Wong Wei Sun Liting Wang Quanfang Wei Haiying Ran Liqun Zhang Hengning Lian Wei Huang Yuzhang Wu 李启靖 万瑛 | 2017 | 科学新闻2017，19，4： | 0 |
| 11 | A novel online analyzer for accurate and rapid measurement of volatile fatty acids in anaerobic wastewater treatment显示文摘Volatile fatty acids(VFAs), which are largely generated during the anaerobic acidification process, are considered to be reliable indicators of the stable process operation. However,the common methods for monitoring VFAs are offline, and they are typically manual requiring time-consuming, costly and complex instruments. This study aims to develop a novel online analyzer for automatic measuring VFAs, which was based on the 5-p H point titration, embedded with a proportional-integral-derivative(PID) feedback control system. The results show that it can achieve accurate and rapid monitoring of VFAs ranging between 0-400 mg/L(<9 min/sample) but simultaneously faces the problems of overtitration and interference of complex characteristics of wastewater. In order to improve its accuracy and stability, the effects of three general coefficients(K_(I),K_(P), and K_(D)) of PID on the titration were investigated, and the optimal values of K_(I), K_(P), and K_(D)were found to be 1.5, 1.0, and-1.0~0.5,respectively. Besides, the initial titration speed was set at 0.06 m L/min, equal to the minimum speed of the peristaltic pump, and the dichotomy approach was integrated into the PID feedback controller. Owing to the above improvements, the relative mean deviation and standard deviation of measuring VFAs in both synthetic and real wastewaters were mostly lower than 5.0% and 5.0 mg/L, proving the online analyzer is rapid, accurate and reliable. | Qingshan Lin Yanchao Yuan Feixiang Zan Hui Lu Zongping Wang Gang Guo | 2022 | Journal of Environmental Sciences2022，34，12： | 0 |
| 12 | Identification of S-RNase genotype and analysis of its origin and evolutionary patterns in Malus plants显示文摘Identification of the S genotype of Malus plants will greatly promote the discovery of new genes,the cultivation and production of apple,the breeding of new varieties,and the origin and evolution of self-incompatibility in Malus plants.In this experiment,88 Malus germplasm resources,such as Aihuahong,Xishuhaitang,and Reguanzi,were used as materials.Seven gene-specific primer combinations were used in the genotype identification.PCR amplification using leaf DNA produced a single S-RNase gene fragment in all materials.The results revealed that 70 of the identified materials obtained a complete S-RNase genotype,while only one S-RNase gene was found in 18 of them.Through homology comparison and analysis,13 S-RNase genotypes were obtained:S_(1)S_(2)(Aihuahong,etc.),S_(1)S_(28)(Xixian Haitang,etc.),S_(1)S_(51)(Hebei Pingdinghaitang),S_(1)S_(3)(Xiangyangcun Daguo,etc.),S_(2)S_(3)(Zhaiyehaitang,etc.),S_(3)S_(51)(Xishan 1),S_(3)S_(28)(Huangselihaerde,etc.),S_(2)S_(28)(Honghaitang,etc.),S_(4)S_(28)(Bo 11),S_(7)S_(28)(Jiuquan Shaguo),S_(10)S_e(Dongchengguan 13),S_(10)S_(21)(Dongxiangjiao)and S_(3)S_(51)(Xiongyue Haitang).Simultaneously,the frequency of the S gene in the tested materials was analyzed.The findings revealed that different S genes had varying frequencies in Malus resources,as well as varying frequencies between intraspecific and interspecific.S_(3)had the highest frequency of 68.18%,followed by S_(1)(42.04%).In addition,the phylogenetic tree and origin evolution analysis revealed that the S gene differentiation was completed prior to the formation of various apple species,that cultivated species also evolved new S genes,and that the S_(50)gene is the oldest S allele in Malus plants.The S_(1),S_(29),and S_(33)genes in apple-cultivated species,on the other hand,may have originated in M.sieversii,M.hupehensis,and M.kansuensis,respectively.In addition to M.sieversii,M.kansuensis and M.sikkimensis may have also played a role in the origin and evolution of some Chinese apples. | Zhao Liu Yuan Gao Kun Wang Jianrong Feng Simiao Sun Xiang Lu Lin Wang Wen Tian Guangyi Wang Zichen Li Qingshan Li Lianwen Li Dajiang Wang | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 13 | Task Offloading Optimization for AGVs with Fixed Routes in Industrial IoT Environment显示文摘In order to solve the delay requirements of computing intensive tasks in industrial Internet of things,edge computing is moving from theoretical research to practical applications.Edge servers(ESs)have been deployed in factories,and on-site auto guided vehicles(AGVs),besides doing their regular transportation tasks,can partly act as mobile collectors and distributors of computing data and tasks.Since AGVs may offload tasks to the same ES if they have overlapping path segments,resource allocation conflicts are inevitable.In this paper,we study the problem of efficient task offloading from AGVs to ESs,along their fixed trajectories.We propose a multi-AGV task offloading optimization algorithm(MATO),which first uses the weighted polling algorithm to preliminarily allocate tasks for individual AGVs based on load balancing,and then uses the Deep Q-Network(DQN)model to obtain the updated offloading strategy for the AGV group.The simulation results show that,compared with the existing methods,the proposed MATO algorithm can significantly reduce the maximum completion time of tasks and be stable under various parameter settings. | Peng Liu Zifu Wu Hangguan Shan Fei Lin Qi Wang Qingshan Wang | 2023 | China Communications2023，20，5： | 0 |
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