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| 1 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 2 | Broadband terahertz wave generation from an epsilon-near-zero material显示文摘Broadband light sources emitting in the terahertz spectral range are highly desired for applications such as noninvasive imaging and spectroscopy.Conventionally,THz pulses are generated by optical rectification in bulk nonlinear crystals with millimetre thickness,with the bandwidth limited by the phase-matching condition.Here we demonstrate broadband THz emission via surface optical rectification from a simple,commercially available 19nmthick indium tin oxide(ITO)thin film.We show an enhancement of the generated THz signal when the pump laser is tuned around the epsilon-near-zero(ENZ)region of ITO due to the pump laser field enhancement associated with the ENZ effect.The bandwidth of the THz signal generated from the ITO film can be over 3 THz,unrestricted by the phasematching condition.This work offers a new possibility for broadband THz generation in a subwavelength thin film made of an ENZ material,with emerging physics not found in existing nonlinear crystals. | Wenhe Jia Meng Liu Yongchang Lu Xi Feng Qingwei Wang Xueqian Zhang Yibo Ni Futai Hu Mali Gong Xinlong Xu Yuanyuan Huang Weili Zhang Yuanmu Yang Jiaguang Han | 2021 | Light(Science & Applications)2021，10，1： | 4 |
| 3 | Lamprey buccal gland secretory protein-2 (BGSP-2) inhibits human T lymphocyte proliferation显示文摘Lamprey is a representative of the agnathans, the most ancient class of vertebrates. Parasitic lampreys secrete anticoagulantfrom their buccal glands and prevent blood coagulation of host fishes. We identified a buccal gland secretory protein-2(BGSP-2) from a buccal gland cDNA library of Lampetra japonica. The full-length BGSP-2 gene was cloned and the recombinantBGSP-2 protein was generated. The role of BGSP-2 on lymphocyte proliferation was studied by examining its effects onhuman T lymphocytes. We found that lamprey BGSP-2 was able to effectively block the proliferation of T cells in vitro by inducingG_1/S cell cycle arrest. Furthermore, it inhibited the proliferation of human T lymphocytes stimulated by phytohemagglutinin(PHA) at a minimum concentration of 0.1μg/ml. Our data suggest that lamprey BGSP-2 is able to block the mitosis of humanT lymphocytes at the G1/S point, and has the potential of anti-proliferative effect on PHA-activated T | Jing SUN Shuiyan YU Zhuang XUE Cenjie LIU Yu WU Xin LIU Qingwei LI | 2010 | Current Zoology2010，56，2： | 3 |
| 4 | Modified halloysite nanotubes reduce the toxic effects of zearalenone in gestating sows on growth and muscle development of their offsprings显示文摘Background: Zearalenone(ZEN) is an estrogenic mycotoxin that is primarily produced by Fusarium fungi and has been proven to affect the reproductive capacity of many species to varying degrees. The present experiment was designed to study the maternal persistent effects of zearalenone toxicity in gestating sows on growth and muscle development of their offsprings, and the alleviation of zearalenone toxicity by modified halloysite nanotubes(MHNTs).Methods: Eighteen sows were fed with one of three dietary treatments that included the following:(1) a control diet,(2) a contaminated grain diet(with 50 % moldy corn, 2.77 mg/kg ZEN), and(3) a contaminated grain diet(with 50 %moldy corn, 2.76 mg/kg ZEN) + 1 % MHNTs. Each sow was exclusively fed its experimental diets from 35 to 70 d of gestation at a total of 2 kg daily. Muscle samples were collected from six piglets per treatment at birth, weaning and finishing.Results: The results showed that feeding the sows with the ZEN-contaminated diets from 35 to 70 d of gestation decreased the ADG, ADFI and G:F of their offsprings(P < 0.05). The muscle fiber numbers in the newborn, weaning and growing-finishing pigs and the muscle fiber diameters at birth and weaning were also decreased by maternal ZEN exposure(P < 0.05). The expressions of IGF-I, IGF-II, Myf-5 and Mstn at birth and IGF-II, Pax7, Myf-5 and Myo D1 at weaning were altered by feeding gestating sows with ZEN-contaminated diets(P < 0.05). The MHNTs reduced most of the ZEN-induced toxic effects: the ADG and ADFI on growth performance, the muscle fiber numbers at weaning and finishing and the muscle fiber diameters at weaning(P < 0.05). The expression levels of IGF-II and Mstn in newborn piglets and IGF-II and Myf-5 in weaning piglets were also prevented by adding 1 % MHNTs(P < 0.05).Conclusions: The present study demonstrated that the offsprings of sows fed with ZEN-contaminated diets from 35 to 70 day of gestation exhibited weakening on growth performance, physiological changes in their muscle fibers and alterations of m RNA expression in their muscle tissues, and also indicated that MHNTs prevented most of the ZENinduced weakening in the muscle tissues. | Rui Gao Qingwei Meng Jianan Li Min Liu Yuanyuan Zhang Chongpeng Bi Anshan Shan | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 3 |
| 5 | The Intronic cis Element SE1 Recruits trans-Acting Repressor Complexes to Repress the Expression of ELONGATED UPPERMOST INTERNODE1 in Rice显示文摘 | Yongyao Xie Yaling Zhang Jingluan Han Jikai Luo Gousi Li Jianle Huang Haibin WU Qingwei Tian Qinlong Zhu Yuanling Chen Yoji Kawano Yao-Guang Liu Letian Chen | 2018 | Molecular Plant2018，11，5： | 3 |
| 6 | Effects of the recombinant toxin protein rLj-RGD3 in multidrug-resistant human breast carcinoma cells显示文摘我们以前报导了那 Lj-RGD3,新奇 RGD 毒素蛋白质,从 Lampetra 的口腔的腺被孤立装饰用的梨树。recombinant 蛋白质 rLj-RGD3 有反侵略并且在肿瘤房间(HeLa 房间) 和在 vitro 的 endothelial 房间(ECV304 房间) 的反粘合剂活动,并且禁止 v3, v5,和 1 调停 integrin 的粘附。在这研究,我们在药抵抗的 MCF-7/Adr 胸癌细胞线和药敏感的父母线 MCF-7 调查了 rLj-RGD3 的 bioactivity,并且发现 rLj-RGD3 禁止了两根细胞线的生长。生物功能研究表明 rLj-RGD3 能在 MCF-7/Adr 导致 apoptosis,它在药敏感的父母线 MCF-7 是比那更流行的。另外, rLj-RGD3 禁止了 MCF-7/Adr 房间的粘附到 fibronectin。而且, rLj-RGD3 通过人工的 matrigel 地下室膜阻止了 MCF-7/Adr 房间的侵略。在摘要, rLj-RGD3 可以在 multidrug 抵抗的乳癌治疗被用作潜在的药。 | Jihong Wang Rong Xiao Xin Liu Fenfang Wu Yue Pang Bo Feng Donghui Yang Qingwei Li | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 3 |
| 7 | Cloning of the kininogen gene from Lampetra japonica provides insights into its phylogeny in vertebrates显示文摘Kininogens, the precursors of bradykinins, ubiquitously exist in vertebrates, including mammals, birds, amphibians, and fishes.To elucidate the phylogeny of kininogen genes in early vertebrates, we cloned the full-length cDNA of kininogen gene from the liver of Lampetra japonica.The open reading frame of this sequence contained 546 bp and encoded 181 amino acids, including a cystatin domain without the canonical binding site for cysteine proteinases and a bradykinin domain.Our results suggested that in lampreys and most of other vertebrates, there might be only one kininogen gene, which was fused by certain sequences during vertebrate evolution and encoded proteins with more functions;however, another special kininogen gene, only encoding the bradykinin domain with multiple copies in some species, arose only in amphibians for adapting themselves to the unique environment.Using reverse transcription PCR, kininogen mRNA was also detected in lamprey gut, kidney, and leukocyte, but absent in lamprey buccal gland.Our findings may provide insights into the phylogeny of kininogen genes as well as other gene families in vertebrates. | Liwei Zhou Xin Liu Ping Jin Qingwei Li | 2009 | Journal of Genetics and Genomics2009，36，2： | 3 |
| 8 | A novel Lyn-like protein tyrosine kinase identified in lamprey and its role in immune response显示文摘The avian sarcoma virus transforming gene(Src)kinase family,a type of nonmreceptor protein tyrosine kinases(nrTPKs),has been reported to play roles in cell growth,division,migration,adhesion,the immune response,and signal transduction berween cells[1,2].The Src family kinases can be divided into three subfamilies based on their conserved domains:SrcA subfamily(Sre,Yes,Fyn,and Fgr,SrcB subfamily(Lck,Hck,Blk,and Lyn),and Frk subfamily[3]. | Tingting Zhao Kedi Luo Xin Liu Shanshan Dong Yinglun Han Meng Gou Peng Su Qingwei Li Ting Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 9 | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats显示文摘In this study, rat models of Parkinson's disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was significantly increased, while monoamine oxidase B mRNA expression was significantly decreased in the Zhichan powder group, compared with the model group. In addition, the levels of striatal dopamine and homovanillic acid, the ratio of dopamine to homovanillic acid, and the activity of blood superoxide dismutase were all higher in the Zhichan powder group than in the model group, but the content of malondialdehyde in blood was lower. Our experimental findings indicate that Zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson's disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. | Qingwei Zhou Jiajun Chen Shihong Yi Yongwei Lou Weimin Tang Yongmao Liu Pengguo Zhang | 2012 | Neural Regeneration Research2012，7，27： | 2 |
| 10 | Improved plasmid-based recovery of coxsackievirus A16 infectious clone driven by human RNA polymerase I promoter显示文摘Dear Editor,Coxsackievirus A16(CA16)is one of the major viral pathogens associated with hand,foot,and mouth disease.CA16 belongs to the Enterovirus genus of the Picornaviridae family and possesses a single-stranded positivesense RNA genome(Mao et al.,2014).Reverse genetics is an important tool for CA16 research.Previously,a reverse genetics T7 polymerase-based system was de- | xiaoli wang chaoyun shen tan chen ke lan zhong huang yunfang zhang qingwei liu | 2016 | Virologica Sinica2016，31，4： | 2 |
| 11 | Nonvolatile reconfigurable dynamic Janus metasurfaces in the terahertz regime显示文摘Metasurfaces,especially tunable ones,have played a major role in controlling the amplitude,phase,and polarization of electromagnetic waves and attracted growing interest,with a view toward a new generation of miniaturized devices.However,to date,most existing reconfigurable devices are bounded in volatile nature with sustained external energy to maintain and single functionality,which restrict their further applications.Here,we demonstrate for the first time,to our knowledge,nonvolatile,reconfigurable,and dynamic Janus metasurfaces by incorporating phase-change material Ge_(2)Se_(2)Te_(5)(GST)in the terahertz(THz)regime.First,we experimentally show the reversible switching characteristic of GST on large areas by applying a single nanosecond laser pulse,which exhibits excellent contrast of THz properties in both states.Then,we present a multiplex metasurface scheme.In each metasurface,three sets of structures are adopted,in which two sets integrate GST.The effective structures can be reversely modulated by the amorphization and crystallization of GST.As a proof of concept,the dynamic beam splitter,bifocal metalens,dual-mode focusing optical vortex generators,and switchable metalens/focusing optical vortex generators are designed,fabricated,and experimentally characterized,and can be switched reversibly and repeatedly with the help of optical and thermal stimuli.Our scheme will pave the way toward the development of multifunctional and compact THz devices and may find use for applications in THz imaging,sensing,and communications. | SHOUJUN ZHANG XIEYU CHEN KUAN LIU HAIYANG LI YUEHONG XU XIAOHAN JIANG YIHAN XU QINGWEI WANG TUN CAO ZHEN TIAN | 2022 | Photonics Research2022，10，7： | 2 |
| 12 | A quasi-3D Fano resonance cavity on optical fiber end-facet for high signal-to-noise ratio dip-and-read surface plasmon sensing显示文摘Surface plasmon devices mounted at the end-facets of optical fibers are appealing candidates for rapid and point-of-care sensing applications,by offering a special dip-and-read operation mode.At present,these devices’noise-equivalent limits-of-detection lag far behind the free-space counterparts,leaving them incapable of most biosensing applications.Here we report a quasi-3D Fano resonance cavity and its fabrication method to fundamentally improve the quality factor and coupling efficiency for fiber-coupled surface plasmon resonance.In this device,the Fano resonance combines the high coupling efficiency of a Fabry-Pérot etalon and the high quality factor resonance of a plasmonic crystal cavity.The quasi-3D device was fabricated on a planar substrate and transferred to a single-mode fiber end-facet,which requires a low-adhesion yet surface-plasmon-tunneling interface between the device and the planar substrate.Such an interface was realized with a nanocap-slit unit structure,of which the plasmonic crystal was consisted.A noise-equivalent limit of detection of~10-7 RIU was experimentally obtained,allowing bovine serum albumin physical adsorption to be distinguished at ng mL-1 level concentrations.Therefore,breaking through the long-standing signal-to-noise ratio bottleneck,this work makes fiber end-facet surface plasmon devices into one of high sensitivity label-free sensing technologies.At the same time,it provides an enabling top-down fabrication technology for making 3D plasmonic structures on fiber end-facets at the nanometer scale. | Xiaqing Sun Zeyu Lei Hao Zhong Chenjia He Sihang Liu Qingfeng Meng Qingwei Liu Shengfu Chen Xiangyang Kong Tian Yang | 2022 | Light(Advanced Manufacturing)2022，3，4： | 2 |
| 13 | Genome Size of Alexandrium catenella and Gracilariopsis lemaneiformis Estimated by Flow Cytometry显示文摘Flow cytometry(FCM) technique has been widely applied to estimating the genome size of various higher plants. However, there is few report about its application in algae. In this study, an optimized procedure of FCM was exploited to estimate the genome size of two eukaryotic algae. For analyzing Alexandrium catenella, an important red tide species, the whole cell instead of isolated nucleus was studied, and chicken erythrocytes were used as an internal reference. The genome size of A. catenella was estimated to be 56.48 ± 4.14 Gb(1C), approximately nineteen times larger than that of human genome. For analyzing Gracilariopsis lemaneiformis, an important economical red alga, the purified nucleus was employed, and Arabidopsis thaliana and Chondrus crispus were used as internal references, respectively. The genome size of Gp. lemaneiformis was 97.35 ± 2.58 Mb(1C) and 112.73 ± 14.00 Mb(1C), respectively, depending on the different internal references. The results of this research will promote the related studies on the genomics and evolution of these two species. | DU Qingwei SUI Zhenghong CHANG Lianpeng WEI Huihui LIU Yuan MI Ping SHANG Erlei Zeeshan Niaz QUE Zhou | 2016 | Journal of Ocean University of China2016，15，4： | 2 |
| 14 | Dynamic Response of Offshore Wind Turbine on 3×3 Barge Array Floating Platform under Extreme Sea Conditions显示文摘Offshore wind farm construction is nowadays state of the art in the wind power generation technology.However,deep water areas with huge amount of wind energy require innovative floating platforms to arrange and install wind turbines in order to harness wind energy and generate electricity.The conventional floating offshore wind turbine system is typically in the state of force imbalance due to the unique sway characteristics caused by the unfixed foundation and the high center of gravity of the platform.Therefore,a floating wind farm for 3×3 barge array platforms with shared mooring system is presented here to increase stability for floating platform.The NREL 5 MW wind turbine and ITI Energy barge reference model is taken as a basis for this work.Furthermore,the unsteady aerodynamic load solution model of the floating wind turbine is established considering the tip loss,hub loss and dynamic stall correction based on the blade element momentum(BEM)theory.The second development of AQWA is realized by FORTRAN programming language,and aerodynamic-hydrodynamic-Mooring coupled dynamics model is established to realize the algorithm solution of the model.Finally,the 6 degrees of freedom(DOF)dynamic response of single barge platform and barge array under extreme sea condition considering the coupling effect of wind and wave were observed and investigated in detail.The research results validate the feasibility of establishing barge array floating wind farm,and provide theoretical basis for further research on new floating wind farm. | LIU Qing-song MIAO Wei-pao YUE Min-nan LI Chun WANG Bo DING Qingwei | 2021 | China Ocean Engineering2021，35，2： | 2 |
| 15 | Studies of the Geodesic Acoustic Mode Zonal Flow in HL-2A Tokamak Plasmas显示文摘 | ZHAO Kaijun DONG Jiaqi YAN Longwen HONG Wenyu QIAN Jun CHENG Jun YU Deliang YANG Qingwei DING Xuantong LIU Yong PAN Chuanhong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 2 |
| 16 | Low concentrations of the recombinant toxin protein rLj-RGD3 suppress TNF-a-induced human renal carcinoma cell invasion显示文摘肾的房间癌(RCC ) 的一个特点侵略由 gelatinase 酶的本地生产是细胞外的矩阵(ECM ) 的降级。矩阵 metalloproteinase-9 (MMP-9 ) 导致了癌症房间侵略是在癌症的枢轴的步之一转移。它被报导了那个肿瘤坏死因素 --(TNF-) , MMP-9 的一个管理者,能在人的肾的癌房间导致侵略。在我们的实验室的以前的工作显示出那 rLj-RGD3,从 Lampetra 装饰用的梨树的口腔的腺分泌物的 recombinant RGD (ArgGlyAsp ) 毒素蛋白质,拥有反肿瘤活动。在这研究,我们证明 rLj-RGD3 压制了 TNF -- 在 786-0 房间(人的肾的癌房间) 的导致的 MMP-9 分泌物。在 TNF 上调查 rLj-RGD3 的规章的效果 -- 导致的 MMP-9 分泌物,我们预先对待有 rLj-RGD3 的房间。有趣地, rLj-RGD3 没在 MMP 的组成的分泌物上有重要效果。然而, rLj-RGD3 的低集中减少了 TNF -- 导致的 MMP-9 分泌物。功能的研究表明 rLj-RGD3 导致了 apoptosis 并且显著地禁止了 786-0 房间的增长,迁居,和侵略。而且,在房间的肌动朊建筑学与 rLj-RGD3 预先对待被聚集并且瓦解。我们的调查结果建议 rLj-RGD3 可以在肾的癌症被用作潜在的药治疗。 | Minli Jin Rong Xiao Jihong Wang Xin Liu Yu Liu Zhuang Xue Li Lv Yuanyuan Zheng Qingwei Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 2 |
| 17 | Gray Correlation Degree Analysis of Controlling Factors on Coal Deformation 显示文摘 | WANG Qingwei LIU Gaofeng WANGXiaobo | 2011 | Energy Exploration & Exploration2011，29，2： | 1 |
| 18 | Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group显示文摘 | Qingwei Chen Ying Liu Linlin Pei Dazhi Ke Guiqiong Li Wei Deng Wuwei Yao | 2009 | The International Journal of Cardiovascular Imaging2009，，2： | 1 |
| 19 | Reconfigurable and nonvolatile terahertz lithography-free photonic devices based on phase change films显示文摘High-performance terahertz(THz)devices with reconfigurable features are highly desirable in many promising THz applications.However,most of the existing reconfigurable THz elements are still limited to volatile responses,single functionality,and time-consuming multistep manufacturing procedures.In this paper,we report a lithography-free approach to create reconfigurable and nonvolatile THz components by exploring the reversible,nonvolatile,and continuous THz modulation capability of the phase change material Ge_(2)Sb_(2)Te_(5).As a proof of concept,THz gratings with significant Rayleigh anomalies and diffraction as well as ultrathin THz flat lenses with subwavelength and ultra-broadband focusing capabilities are designed and fabricated on ultrathin Ge_(2)Sb_(2)Te_(5)films using the presented photo-imprint strategy.Moreover,such a method can also be adopted to create more complex THz devices,such as Pancharatnam–Berry phase metasurfaces and grayscale holographic plates.With these findings,the proposed method will provide a promising solution to realize reconfigurable and nonvolatile THz elements. | XIEYU CHEN SHOUJUN ZHANG KUAN LIU YUEHONG XU XIAOHAN JIANG HAIYANG LI XI FENG QINGWEI WANG YONGCHANG LU KEMENG WANG TUN CAO ZHEN TIAN | 2023 | Photonics Research2023，11，4： | 1 |
| 20 | New Diagnostic Systems on HL-2A Tokamak显示文摘 | DING Xuantong ZHOU Yan DENG Zhongchao XIAO Weiwen LIU Zetian SHI Zhongbing YAN Longwen HONG Wenyu YANG Qingwei | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 1 |
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