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    题名 作者 年代 出处 被引量
1Reaction kinetics of CaC2 formation from powder and compressed feeds显示文摘Renxing Wang Zhenyu Liu Leiming Ji Xiaojin Guo Xi Lin Junfei Wu Qingya Liu 2016Frontiers of Chemical Science and Engineering2016,10,4:6
2Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China显示文摘OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART.Yuan Jun Xu Qianlei Chen Xiumin Meng Pengfei Li Qingya Xu Liran Meng Xiangle Jin Yantao Guo Huijun 2019Journal of Traditional Chinese Medicine2019,39,2:5
3Structures of the endogenous peptide-and selective non-peptide agonist-bound SSTR2 signaling complexes显示文摘Dear Editor,Somatostatin,also known as growth hormone-inhibiting hormone,is an important peptide hormone that mediates predominanty neuroendocrine inhibitory effects in the exocrine and endocrine systems,12 Besides,t can also exert potent regulatory effects on cell proliferation and angiogenesis.3 In human,somatostatin exerts its physiological functions through activating five somatostatin receptors(SSTRs),which are class A Gvo protein-coupled receptors,Pharmacologicaly,somatostatin receptors,especially SSTR2,are the primary drug targets for the treatment of pituitary adenomas and neuroendocrine tumors.-s To date,three somatostatin analogs have been approved for clinical use and two of them(lanreotide and octreotide)are sSTR2-selective drugs.3 In addition to peptidic agonists,extensive efforts have also been made to design selective small-molecule agonists,t which will failitate the development of orly active chemotherapeutic agents.Li-Nan Chen Wei-Wei Wang Ying-Jun Dong Dan-Dan Shen Jia Guo Xuefei Yu Jiao Qin Su-Yu Ji Huibing Zhang Qingya Shen Qiaojun He Bo Yang Yan Zhang Qinglin Li Chunyou Mao 2022Cell Research2022,32,8:0
420μm-Thick Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)-Based Flexible Solid Electrolytes for All-Solid-State Lithium Batteries显示文摘The doped garnet-type solid electrolytes are attracting great interest due to high ionic conductivity and excellent electrochemical stability against Li metal.However,the thick electrolyte layer and rigid nature as well as poor interfacial contact are huge obstacles for its application in all-solid-state lithium batteries.Herein,an ultrathin flexible Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)-(LLZTO-)based solid electrolyte with 90 wt%LLZTO content is realized through solvent-free procedure.The resultant 20μm-thick LLZTO-based film exhibits ultrahigh ionic conductance of 41.21 mS at 30℃,excellent oxidation stability of 4.6 V,superior thermal stability and nonflammability.Moreover,the corresponding Li||Li symmetric cell can stable cycle for more than 2000 h with low overpotential at 0.1mAcm^(-2)under 60℃.The assembled Li||LiFePO4 pouch cell with integrated electrolyte/cathode interface exhibits excellent rate performances and cycle performances with a capacity retention of 71.4%from 153 mAh g^(-1)to 109.2 mAh g^(-1)at 0.1 C over 500 cycles under 60℃.This work provides a promising strategy towards realizing ultrathin flexible solid electrolyte for high-performance all-solid-state lithium batteries.Qingya Guo Fanglin Xu Lin Shen Shungui Deng Zhiyan Wang Mengqi Li Xiayin Yao 2022Energy Material Advances2022,,1:0
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