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| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | Dysregulated adaptive immune response contributes to severe COVID-19显示文摘Dear Editor,The outbreak of the new coronavirus 5ARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus,the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning1. | Kuai Yu Jingjing He Yongjian Wu Baosong Xie Xuefei Liu Bo Wei Haibo Zhou Bingliang Lin Zhixiang Zuo Wen Wen Wenxiong Xu Bin Zou Lai Wei Xi Huang Penghui Zhou | 2020 | Cell Research2020，30，9： | 1 |
| 3 | Med19 Promotes Osteosarcoma Growth and Metastasis and Associates with Prognosis显示文摘 | Wenxi Yu Zhang Zhichang Min Daliu Yang Qingcheng Du Xuefei Tang Lina Lin Feng Sun Yuanjue Zhao Hui Zheng Shuier He Aina Li Hongtao Yao Yang Zan Shen | 2014 | European Journal of Cancer2014，，： | 1 |
| 4 | A loop-mediated isothermal amplification method targets the phoP gene for the detection of Salmonella in food samples显示文摘 | Xuefei Li Shu Zhang Hongwei Zhang Lihuai Zhang Haitao Tao Jia Yu Wenjie Zheng Chenghu Liu Dan Lü Rong Xiang Yin Liu | 2009 | International Journal of Food Microbiology2009，，3： | 1 |
| 5 | Seismic Centrifuge Modelling of Offshore Wind Turbine with Tripod Foundation显示文摘 | Hao Yu Xiangwu Zeng Xuefei Wang | 2014 | Journal of Energy and Power Engineering2014，8，3： | 1 |
| 6 | Carbon fluxes and soil carbon dynamics along a gradient of biogeomorphic succession in alpine wetlands of Tibetan Plateau显示文摘Hydrological changes under climate warming drive the biogeomorphic succession of wetlands and may trigger substantial carbon loss from the carbon-rich ecosystems.Although many studies have explored the responses of wetland carbon emissions to short-term hydrological change,it remains poorly understood how the carbon cycle evolves with hydrology-driven wetland succession.Here,we used a space-for-time approach across hydrological gradients on the Tibetan Plateau to examine the dynamics of ecosystem carbon fluxes(carbon dioxide(CO_(2))and methane(CH4))and soil organic carbon pools during alpine wetland succession.We found that the succession from mesic meadow to fen changed the seasonality of both CO_(2) and CH4 fluxes,which was related to the shift in plant community composition,enhanced regulation of soil hydrology and increasing contribution of spring-thaw emission.The paludification caused a switch from net uptake of gaseous carbon to net release on an annual timescale but produced a large accumulation of soil organic carbon.We attempted to attribute the paradox between evidence from the carbon fluxes and pools to the lateral carbon input and the systematic changes of historical climate,given that the wetlands are spatially low-lying with strong temporal climate-carbon cycle interactions.These findings demonstrate a systematic change in the carbon cycle with succession and suggest that biogeomorphic succession and lateral carbon flows are both important for understanding the long-term dynamics of wetland carbon footprints. | Hao Wang Lingfei Yu Litong Chen Zhenhua Zhang Xuefei Li Naishen Liang Changhui Peng Jin-Sheng He | 2023 | Fundamental Research2023，3，2： | 1 |
| 7 | Effects of laser powder bed fusion process parameters on microstructure and hydrogen embrittlement of high-entropy alloy显示文摘Hydrogen embrittlement behavior, micro-deformation, and crack propagation mechanism of CoCrFeNiMn high-entropy alloy (HEA) fabricated by laser powder bed fusion (LPBF) under different parameters were investigated by slow strain rate tensile tests (at room temperature) with/without electrochemical hydrogen pre-charging. The LPBF CoCrFeNiMn HEA shows excellent resistance to hydrogen embrittlement. Unsuitable LPBF parameters are accompanied by many microcracks and holes, resulting in a slight decrease in the hydrogen embrittlement resistance of the material. The electron backscatter diffraction (EBSD), electron channeling contrast image (ECCI) techniques, and transmission electron microscope (TEM) were carried out to research the main influencing factors of hydrogen on the deformation mechanism and crack propagation. Compared with un-charged samples, a larger number of deformation twins (DTs) appear in the deformation process of hydrogen-charged LPBF CoCrFeNiMn, attributing to the reduction of stacking fault energy (SFE) due to the ingress of hydrogen. The nano DTs and crossing twin system contribute to the extra work hardening, and a strain hardening platform is observed for all hydrogen-charged samples, resulting in the increase of strain hardening rate or the mitigation of the loss of strain hardening. Although unsuitable process parameters will trigger fabrication defects and reduce mechanical properties, the cellular structure can bring a hydrogen-induced strain hardening platform for LPBF CoCrFeNiMn to reduce the damage caused by hydrogen embrittlement. | Hongxu Cheng Hong Luo Zhimin Pan Xuefei Wang Qiancheng Zhao Yu Fu Xiaogang Li | 2023 | Journal of Materials Science & Technology2023，，24： | 0 |
| 8 | Aptamer-Based Fluorescent Assay for Sensitive Detection of Cardiac Troponin Ⅰ显示文摘Acute myocardial infarction(AMI)is a major health problem leading to high rates of mortality and morbidity.Biomarker cardiac troponin I(cTnI)has shown high sensitivity and specificity towards AMI detection,and has been regarded as'gold standard'.An ultrasensitive method to detectcTnI with low concentration in human fluid is essential.In this paper,we developed an aptamer-based assay coupled with rolling circle amplification(RCA)and molecular beacon probe for sensitive detection ofcTnI.In this strategy,aptamer acts as a bridge to communicate between oligonucleotides andcTnI.RCA reaction produces a single-stranded tandem repeated copy of the circular template,which are recognized by fluorescence molecular beacon probe.With this strategy,highly sensitive and specific detection of cTnI was realized with the lowest detectable concentration of 7.24 pg/m L.The developed aptamer-RCA assay can be a promising tool in clinical samples analysis.The assay can also analyze other disease-related biomarkers by replacing the aptamer. | Yu Li Yuanzhan Yang Xuefei Lu Yulin Deng | 2020 | Journal of Beijing Institute of Technology2020，29，1： | 0 |
| 9 | Origin of boron in the Damxung Co Salt Lake(central Tibet):Evidence from boron geochemistry and isotopes显示文摘The origin of boron in boron-rich salt lakes in the Tibetan Plateau has long been the subject of debate.The Damzung Co Salt Lake in central Tibet has high boron concentrations(B=276–313 mg/L)and is an ideal site | Lü Yuanyuan ZHENG Mianping CHEN Wenxi ZHANG Xuefei LIU Xifang WU Qian YU Jiangjiang | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
| 10 | Dynamic computation offloading in time-varying environment for ultra-dense networks:a stochastic game approach显示文摘To meet the demands of large-scale user access with computation-intensive and delay-sensitive applications,combining ultra-dense networks(UDNs)and mobile edge computing(MEC)are considered as important solutions.In the MEC enabled UDNs,one of the most important issues is computation offloading.Although a number of work have been done toward this issue,the problem of dynamic computation offloading in time-varying environment,especially the dynamic computation offloading problem for multi-user,has not been fully considered.Therefore,in order to fill this gap,the dynamic computation offloading problem in time-varying environment for multi-user is considered in this paper.By considering the dynamic changes of channel state and users’queue state,the dynamic computation offloading problem for multi-user is formulated as a stochastic game,which aims to optimize the delay and packet loss rate of users.To find the optimal solution of the formulated optimization problem,Nash Q-learning(NQLN)algorithm is proposed which can be quickly converged to a Nash equilibrium solution.Finally,extensive simulation results are presented to demonstrate the superiority of NQLN algorithm.It is shown that NQLN algorithm has better optimization performance than the benchmark schemes. | Xie Renchao Liu Xu Duan Xuefei Tang Qinqin Yu Fei Richard Huang Tao | 2021 | The Journal of China Universities of Posts and Telecommunications2021，28，2： | 0 |
| 11 | Optimal planning of high voltage distribution substations显示文摘Aimed at solving the problem of optimal planning for high voltage distribution substations,an efficient method is put forward.The method divides the problem into two sub-problems:source locating and combina tional optimization.The algorithm of allocating and locating alternatively(ALA)is widely used to deal with the source lo cating problem,but it is dependent on the initial location to a large degree.Thus,some modifications were made to the ALA algorithm,which could greatly improve the quality of solutions.In addition,considering the non-convex and nonconcave nature of the sub-problem of combinational optimization,the branch-and-bound technique was adopted to obtain or approximate a global optimal solution.To improve the efficiency of the branch-and-bound technique,some heuristic principles were proposed to cut those branches that may generate a global optimization solution with low probability.Examples show that the proposed algorithm meets the requirement of engineering and it is an effective approach to rapidly solve the problem of optimal planning for high voltage distribution substations. | YU Yixin YAN Xuefei ZHANG Yongwu | 2007 | Frontiers of Electrical and Electronic Engineering in China2007，2，3： | 0 |
| 12 | Chemical composition and pharmacological activities of Polygonum cuspidatum显示文摘Polygonum cuspidatum is a traditional Chinese medicine,and its medicinal part is dry rhizome.It is mainly used to treat damp heat jaundice,burns,carbuncle,ulcer poisoning,amenorrhea,and snake bite.Recent studies have found that P.cuspidatum also contains active ingredients against coronaviruses.This paper reviews the chemical constituents and pharmacological activities of P.cuspidatum,so as to provide a scientific basis for the development and utilization of P.cuspidatum resources in the future. | Yi’an Shi Luming Pan Jiayi Bi Xuefei Yang Jing Sun Meng Zhang Yu Chen | 2022 | Asian Journal of Traditional Medicines2022，17，3： | 0 |
| 13 | Comparative Proteomics Based on 18O Labeling to Evaluate the Hepatotoxicity of Tris(2,3-dibromopropyl) Isocyanuratein Rats显示文摘Detecting protein expression levels in organisms exposed to environmental pollutants can help us understand the action mechanism of toxicity. In the present study, adult female Sprague-Dawley (SD) rats received a consecutive intraperitoneal injection of tris(2,3-dibromopropyl) isocyanurate (TBC) for seven days, and the ^16O/^18O labeling comparative proteomic approach was used to study the change of liver proteome in these rats. Thirty six differential proteins were identified between the control group and the high-dose-exposed group (8 mg/kg), of which, twenty eight proteins were down-regulated and eight proteins were up-regulated. Bioinformatics analysis revealed that most of the differential proteins were related with the metabolic and cellular processes. In addition, the contents of malondialdehyde (MDA), catalase (CAT), and glutathione (GSH) in liver were measured to evaluate the oxidative stress status induced by TBC exposure. Together, these findings showed that TBC might be toxic to liver by disrupting metabolic process and apoptosis. The results might provide a better insight into the mechanism of toxicity induced by TBC. | Yu Li Xuefei Lü Yuanzhan Yang Yulin Deng | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 0 |
| 14 | Function of arsATorf7orf8 of Bacillus sp. CDB 3 in arsenic resistance显示文摘Bacillus sp. CDB3 isolated from an arsenic contaminated cattledip site possesses an uncommon arsenic resistance (ars) operon bearing eight genes in the order of arsRYCDATorf7orf8. We investigated the functions of arsA, arsT, orf7 and orf8 in arsenic resistance using a plasmid-based gene knockout approach in the ars genedeficient Escherichia coli strain AW3110. The CDB3 arsA genewas shown to play a significant role in resistance, suggesting that the encoded ArsA may couplewith the arsenite transporter, forming an ArsAY complex that can enhance arsenite extrusion efficiency. Thedisruption of either arsT or orf7was not observed to affect arsenic resistance in the heterologous E. coli host, but their involvement in arsenic resistance can not be excluded. The orf8 gene is predicted to encode a putativedual-specificity protein phosphatasewhich also shares certain homology to arsenate reductases. The function loss of orf8 resulted in a remarkabledecrease in resistance to arsenate, though not arsenite. To examine if this effectwasdue to the reduction of arsenate by orf8, the arsC genewithin the 8-gene operonwasdisrupted. The resulting abolishment of arsenate resistance suggests that the involvement of orf8 in arsenic resistance is not via reductase activity. | Wei Zheng James Scifleet Xuefei Yu Tingbo Jiang Ren Zhang | 2013 | Journal of Environmental Sciences2013，25，7： | 0 |
| 15 | Technologies for pollutant removal and resource recovery from blackwater:a review显示文摘Blackwater(BW),consisting of feces,urine,flushing water and toilet paper,makes up an important portion of domestic wastewater.The improper disposal of BW may lead to environmental pollution and disease transmission,threatening the sustainabie development of the world.Rich in nutrients and organic matter,BW could be treated for resource recovery and reuse through various approaches.Aimed at providing guidance for the future development of BW treatment and resource recovery,this paper presented a literature review of BWs produced in different countries and types of toilets,including their physiochemical characteristics,and current treatment and resource recovery strategies.The degradation and utilization of carbon(C),nitrogen(N)and phosphorus(P)within BW are underlined.The performance of different systems was classified and summarized.Among all the treating systems,biological and ecological systems have been long and widely applied for BW treatment,showing their universality and operability in nutrients and energy recovery,but they are either slow or ineffective in removal of some refractory pollutants.Novel processes,especially advanced oxidation processes(AOPs),are becoming increasingly extensively studied in BW treatment because of their high efficiency,especially for the removal of micropollutants and pathogens.This review could serve as an instructive guidance for the design and optimization of BW treatment technologies,aiming to help in the fulfilment of sustainable human excreta management. | Wei Zhang Huaqiang Chu Libin Yang Xiaogang You Zhenjiang Yu Yalei Zhang Xuefei Zhou | 2023 | Frontiers of Environmental Science & Engineering2023，17，7： | 0 |
| 16 | Apigenin as a promising myocyte protectant against damage and degradation显示文摘Myocytes power the movement of all organs in the body.Damage to and degradation of myocytes causes hypokinesia and muscle-related degenerative diseases.Apigenin,a kind of flavone,is being used to treat many disorders.It exerts a host of different pharmacological activities,such as anti-inflammatory,anti-mutagenic,cardioprotective,and antioxidant effects.Accordingly,apigenin is considered a promising candidate for myocyte protection.In this review,we introduced the characteristics of apigenin.The means of apigenin protection of myocytes as well as the mechanism were summarized and discussed.The protective effects can be classified into proliferation-promoting,anti-inflammatory,atrophy-preventing,metabolism-increasing,and antioxidative effects.Additionally,we provided some outlook on the valuable applications of apigenin in sports medicine,which eagerly require further fundamental research. | XIAO HUANG ZHIHAI YU LIJUAN NING YU LEI XUEFEI ZHANG ZHUYING WANG | 2022 | BIOCELL2022，46，2： | 0 |
| 17 | Structures of the endogenous peptide-and selective non-peptide agonist-bound SSTR2 signaling complexes显示文摘Dear Editor,Somatostatin,also known as growth hormone-inhibiting hormone,is an important peptide hormone that mediates predominanty neuroendocrine inhibitory effects in the exocrine and endocrine systems,12 Besides,t can also exert potent regulatory effects on cell proliferation and angiogenesis.3 In human,somatostatin exerts its physiological functions through activating five somatostatin receptors(SSTRs),which are class A Gvo protein-coupled receptors,Pharmacologicaly,somatostatin receptors,especially SSTR2,are the primary drug targets for the treatment of pituitary adenomas and neuroendocrine tumors.-s To date,three somatostatin analogs have been approved for clinical use and two of them(lanreotide and octreotide)are sSTR2-selective drugs.3 In addition to peptidic agonists,extensive efforts have also been made to design selective small-molecule agonists,t which will failitate the development of orly active chemotherapeutic agents. | Li-Nan Chen Wei-Wei Wang Ying-Jun Dong Dan-Dan Shen Jia Guo Xuefei Yu Jiao Qin Su-Yu Ji Huibing Zhang Qingya Shen Qiaojun He Bo Yang Yan Zhang Qinglin Li Chunyou Mao | 2022 | Cell Research2022，32，8： | 0 |
| 18 | Oxygen-contained amorphous MoS_(x) cocatalyst by one-step photodeposition to enhance H-adsorption affinity for efficient photocatalytic H_(2)generation显示文摘Traditional bulk MoS_(2) as an effective H_(2)-evolution cocatalyst is mainly subjected to the weak hydrogen-adsorption ability of highporpotion saturated S,resulting in a slow interfacial H_(2)-evolution reaction.In this paper,an efficient strategy for enhancing hydrogen adsorption of saturated S by manipulating electron density through O atoms is proposed to boost photocatalytic performance of CdS.Simultaneously,amorphization of MoS_(2) can further increase the unsaturated active S sites.Herein,oxygencontained amorphous MoS_(x)(a-MoOS_(x))nanoparticles(10-30 nm)were tightly loaded on the CdS surface through a mild photoinduced deposition method by using(NH_(4))_(2)[MoO(S_(4))_(2)]solution as the precursor at room temperature.The photocatalytic H_(2)-evolution result showed that the a-MoOS_(x)/CdS performed the superior H_(2)-production activity(382μmol·h^(-1),apparent quantum efficiencies(AQE)=11.83%)with a lot of visual H_(2)bubbles,which was 54.6,2.5,and 5.1 times as high as that of CdS,MoS_(x)/CdS,and annealed a-MoOS_(x)/CdS,respectively.Characterizations and density functional theory(DFT)calculations revealed the mechanism of improved H_(2)-evolution activity is that the O heteroatom in amorphous MoOS_(x) can enhance the atomic H-adsorption ability by manipulating the electron density to form electron-deficient S^((2-δ)-)sites.This study provides a new idea to improve the efficiency and number of H_(2)-evolution active sites for developing efficient cocatalysts in the field of photocatalytic hydrogen evolution. | Pinsi Deng Ping Wang Xuefei Wang Feng Chen Huogen Yu | 2023 | Nano Research2023，16，7： | 0 |
| 19 | 通过结合决策相关测量和微刺激干扰探测感觉读码显示文摘文章简介在本研究工作中,课题组训练猕猴通过眼动来报告它们所感知到的光流在空间中的运动方向,并在猕猴执行任务的同时,记录了上颞叶内侧皮层(MST)、中颞叶皮层(MT)和腹顶内皮层(VIP)三个脑区的神经元胞外电生理活动. | Xuefei Yu 顾勇 | 2019 | 科学新闻2019，0，2： | 0 |
| 20 | Basic properties of saline soil in Da'an, western Jilin, China显示文摘This paper studied the basic properties of saline soil at different depths of a sampling site in Da'an, China, through field reconnaissance and laboratory analysis. A series of experiments which comprised the analyses of grain size distribution, mineral composition, soil physical properties, soluble salt concent, p H, organic content and cation exchange capacity were conducted. Through these experiments, the distribution rule of each property and their causes are discussed. These results could provide a fundamental base for the study of moisture migration. | Xin Zhou Qing Wang XueFei Zhang TianWen Yu XuDong Zhang | 2015 | Research in Cold and Arid Regions2015，7，5： | 0 |
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