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| 1 | Axin bridges Daxx to p53显示文摘死亡联系域的蛋白质 Daxx 施加包括调停的许多报导功能经由激活 c6 月 N 终端从 FasL 发信号到 apoptosis apoptosis 的 kinase (JNK ) ,正式就职和抑制,和染色质改变的规定。它原来从酵母被克隆用船边交货对相似物体之连续感觉而形成心像口的细胞内部的尾巴的二混血儿的屏幕诱饵。而许多起始的报告仍然保持争论, Daxx 在一系列压力信号包括 UVirradiation,过氧化氢治疗和 TGF- β治疗触发的 apoptosis 的规定起重要作用,是清楚的。在这评论,我们在 Axinbeing 上集中连接 Daxx 到 p53 的一个拴住的因素。 | Sheng-Cai Lin Qinxi Li | 2007 | Cell Research2007，17，4： | 5 |
| 2 | APP physiological and pathophysiological functions: insights from animal models显示文摘淀粉的先锋蛋白质(应用软件) 在最近的年里的集中的学习下面,主要由于它在 Alzheimer 的疾病(广告) 的致病的关键角色。β淀粉(Aβ) 从应用软件解朊的劈开产生的肽能聚集,在人的广告大脑导致匾形成。削尖影响 Aβ 的应用软件的变化;生产被发现为世袭早发作原因家庭广告。它是很可能的那阐明应用软件的生理的性质将极大地在广告致病便于它的角色的理解。很多个应用软件 loss-of-function 和 gain-of-function 模型包括 Caenorhabditis elegans,果蝇, zebrafish 和老鼠在模型有机体被建立了。这些在 vivo 模型提供我们珍贵卓见进应用软件生理的函数。另外,几只敲门在里面老鼠当模特儿在生理的水平表示变异的应用软件是可得到的允许我们没有应用软件 overexpression,学习广告致病。这篇文章将考察生理的水流和应用软件的 pathophysiological 动物模型。 | Qinxi Guo Zilai Wang Hongmei Li Mary Wiese Hui Zheng | 2012 | Cell Research2012，22，1： | 5 |
| 3 | The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation显示文摘由葡萄糖 transporter GLUT4 的刺激胰岛素的葡萄糖举起在整个身体的葡萄糖动态平衡起一个中央作用,哪个导致类型 2 糖尿病的 dysregulation。然而,调整刺激胰岛素的葡萄糖举起的分子的部件和机制仍然保持大部分不清楚。这里,我们证明 Axin 与 ADP-ribosylase tankyrase 交往 2 (TNKS2 ) 并且 kinesin 马达蛋白质 KIF3A,响应胰岛素形成为 GLUT4 translocation 关键的第三的建筑群。特定到血浆膜的复杂稀释刺激胰岛素的 GLUT4 translocation 的单个部件击倒。重要地, TNKS2 −/− 老鼠展出减少的胰岛素敏感和更高的血葡萄糖层次什么时候在 fasting 以后的 re-fed。机械学地,我们证明当胰岛素不在时, Axin, TNKS 和 KIF3A 与 trans-Golgi 网络上的 GLUT4 是 co 局部性的。胰岛素处理压制 TNKS 的 ADP-ribosylase 活动,导致在自动数据处理 ribosylation 和 ubiquitination 的减小 Axin 和 TNKS,和建筑群的并发的稳定。Akt 的抑制,胰岛素发信号的主要受动器 kinase,废除调停胰岛素的复杂稳定。我们因此阐明了直接在刺激胰岛素的 GLUT4 translocation 与马达蛋白质 kinesin 被联系的新蛋白质建筑群。 | Hui-Ling Guo Cixiong Zhang Qi Liu Qinxi Li Guili Lian Di Wu Xuebin Li Wei Zhang Yuemao Shen Zhiyun Ye Slau-Yong Lin Sheng-Cai Lin | 2012 | Cell Research2012，22，8： | 4 |
| 4 | HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy显示文摘 | Zhi‐QinXi Ji‐JunSun Xue‐FengWang Ming‐WeiLi Xian‐ZengLiu Lin‐YuanWang XiZhu FeiXiao Jin‐MeiLi YunGong Li‐FengGuan | 2007 | Synapse2007，，9： | 1 |
| 5 | High sensitivity of semimetal photodetection via Bose–Einstein condensation显示文摘The discovery of semiconductor has witnessed remarkable strides toward high performance of photodetectors attributed to its excellent carrier properties.However,semimetal,owning to the high carrier concentration and low carrier mobility compared to those of semiconductor,is generally considered unsuitable for photodetection.Herein,we demonstrate an outstanding photodetection in a layered semimetal titanium diselenide(TiSe_(2))in Bose-Einstein condensation(BEC)state.High sensitivity of semimetal photodetector is realized in the range of visible,infrared and terahertz bands.The noise equivalent power(NEP)has threefold improvement at the visible and infrared wavebands,and significant decrease by one order of magnitude in the terahertz frequencies via BEC phenomenon,attributed to the electrical parameter variation after condensation.The best NEP value in the terahertz frequency is comparable to that of commercial Si photodetector.Our results show another recipe to fabricate high performance of photodetection via semimetal except for semiconductor and pave the way to exploit macroscopic quantum phenomena for optoelectronics. | Tuntan Wu Qinxi Qiu Yongzhen Li Qiangguo Zhou Wanli Ma Jingbo Li Lin Jiang Wei Zhou Zhiming Huang | 2024 | InfoMat2024，6，2： | 0 |
| 6 | A new method for preparing a rat intracerebral hemorrhage model by combining focused ultrasound and microbubbles显示文摘Background:We aimed to prepare a non-invasive,reproducible,and controllable rat model of intracerebral hemorrhage with focused ultrasound(FUS).Methods:A rat intracerebral hemorrhage(ICH)model was established by combining FUS and microbubbles(μBs),and edaravone was used to verify whether the free radical scavenger had a protective effect on the model.The brain tissue of each group was sectioned to observe the gross histology,blood-brain barrier(BBB)permeability,cerebral infarction volume,and histopathological changes.Results:Compared with the FUS group,the BBB permeability was significantly increased in the FUS+μBs(F&B)group(p=0.0021).The second coronal slice in the F&B group had an obvious hemorrhage lesion,and the FUS+μBs+edaravone(F&B&E)group had smaller hemorrhage areas;however,ICH did not occur in the FUS group.The cerebral infarction volume in the F&B group was significantly larger than that in the FUS group(p=0.0030)and F&B&E group(p=0.0208).HE staining results showed that nerve fibrinolysis,neuronal necrosis,microglia production,and erythrocytes were found in both the F&B group and the F&B&E group,but the areas of the nerve fibrinolysis and neuronal necrosis in the F&B group were larger than the F&B&E group.Conclusions:A rat ICH model was successfully prepared using theμBs assisted FUS treatment,and edaravone had a therapeutic effect on this model.This model can be used to study the pathophysiological mechanism of ICH-related diseases and in preclinical research on related new drugs. | Yao He Jie Yang Fengying Hu Min Liao Yuru Nie Xiaoxia Zhu Tao Zhang Keer Song Qinxi Li Xiaojie Li Chenghan Mei Zhe Wu Qiang Lu Zhihui Zhong | 2023 | Animal Models and Experimental Medicine2023，6，2： | 0 |
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