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| 1 | Significance and strategies in developing delivery systems for bio-macromolecular drugs显示文摘 | Huining HE Qiuling LIANG Meong Cheoi SHIN Kyuri LEE Junbo GONG Junxiao YE Quan LIU Jingkang WANG Victor YANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 2 |
| 2 | Low selenium status affects arsenic metabolites in an arsenic exposed population with skin lesions显示文摘 | Zhi Huang Qiuling Pei Guifan Sun Sichun Zhang Jiang Liang Yi Gao Xinrong Zhang | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 3 | Research Overview on Occurrence and Control of Tetranychus urticae Koch in China显示文摘Tetranychus urticae Koch;Insecticide resistance;Chemical control This paper elaborates the occurrence factors and damage characteristics of Tetranychus urticae Koch in China,and emphatically summarizes three main control strategies of T.urticae,namely agricultural control,chemical control and biological control,as well as research progress in its resistance mechanisms.The problems existing in controlling T.urticae and its resistance management strategies are put forward,to provide a theoretical basis for the resistance management and comprehensive control of T.urticae. | Yang HAN Tingmi YANG Jingcheng WU Qiuling PANG Xiaowen LIANG Binghai LOU | 2023 | Plant Diseases and Pests2023，14，4： | 0 |
| 4 | Experimental study on the regulation effect of Qiaoqin Qingfei agent on cough variant asthma based on airway neurogenic inflammation显示文摘Objective:To investigate the mechanism of regulation of airway neurogenic inflammation by Qiaoqin Qingfei agent in rats with cough variant asthma(CVA).Methods:48 SD rats were randomly divided into blank group,model group,montelukast sodium group(1.05 mg/kg)and high,medium and low dose groups(26,13,6.5 g/kg),with 8 rats in each group.The rat CVA model was established by the method of ovalbumin(OVA)combined with aluminum hydroxide(Al(OH)3)sensitization and repeated stimulation.From the second day of sensitization,the rat CVA model was given by gavage for 28 days.The pathological changes of lung tissue were observed under microscope by HE staining.The content changes of nerve growth factor(NGF)and substance P(SP)in alveolar lavage fluid(BALF)were determined by double-antibody sandwich ABC-ELISA,and the protein expression levels of NGF and SP in lung tissue were detected by immunohistochemistry.Results:Pathological findings showed significant inflammatory manifestations in the model group,and the inflammatory infiltration in the high-dose,medium-dose and low-dose groups of Qiaoqin Qingfei agent and montelukast sodium groups were alleviated to varying degrees.Compared with blank group,the protein expression levels of NGF and SP in lung tissue of model group were significantly increased(P<0.01).Compared with model group,the protein expression levels of NGF and SP in lung tissue and the contents of NGF and SP in alveolar lavage fluid in high-dose,medium-dose and low-dose groups and montelukast sodium group were significantly decreased(P<0.05).Conclusion:Qiaoqin Qingfei agent may reduce airway inflammation and relieve cough variant asthma by regulating the protein expression levels of NGF and SP in airway neurogenic inflammation. | HUANG Hui-si HAN Chao SHI Yan-hong QI Chun-li XIONG Ai-hua ZHANG Qiuling LIANG Hui-ling | 2023 | Journal of Hainan Medical University2023，29，9： | 0 |
| 5 | Curcumin based combination therapy for anti-breast cancer: from in vitro drug screening to in vivo efficacy evaluation显示文摘当药抵抗看起来是在 monotherapy 的越来越多的 anticancer 药的一个不可避免的问题时,联合药治疗成为了一个繁荣的方法减少管理的全部的药剂量以及克服癌房间的药抵抗。Curcumin,考虑了作为 chemoresistance 的一块压板根据它的多重反肿瘤的机制在癌症治疗拥有 multifaceted 角色,能显著地便于它的反癌症功能并且改进经由联合用法与的治疗学的效果许多有不同反应机制的另外的药。探索这可能性,四反癌症都拥有药抵抗问题的某个度的化学疗法的代理人,包括三个酷氨酸 kinase 禁止者( erlotinib , sunitinib 和 sorafenib ),那对不同房间小径和典型 anticancer 药 doxorubicin 正在起作用,个别地与 curcumin 被相结合在 vitro 并且在 vivo 检验 synergistic 反肿瘤效果。结果表明在 0.46 的臼齿的比率与 curcumin 相结合的 sunitinib 在 vitro 产出大多数有势力 synergistic 效果,并且因此为进一步的动物评估被选择。为了推进,提高 anticancer 效果,牛的浆液白朊(BSA ) nanoparticles 作为一个搬运人被利用在 situ 交付选择的药联合。在证实的 vivo 调查结果初步我们能由我们的途径在测试动物为延长时间时期维持类似的注射的药比率的假设,从而最大化还最小化这些药的毒性的治疗学的力量。这个工作能在联合药治疗和实现上开创一条新大街如此的药的临床的用途。 | Sunhui Chen Qiuling Liang Shuping Xie Ergang Liu Zhili Yu Lu Sun Meong Cheol Shin Seung Jin Lee Huining He Victor C. Yang | 2016 | Frontiers of Chemical Science and Engineering2016，10，3： | 0 |
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