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| 1 | MHSS ARAIM Algorithm Combined with Gross Error Detection显示文摘Due to some shortcomings in the current multiple hypothesis solution separation advanced receiver autonomous integrity monitoring(MHSS ARAIM)algorithm,such as the weaker robustness,a number of computational subsets with the larger computational load,a method combining MHSS ARAIM with gross error detection is proposed in this paper.The gross error detection method is used to identify and eliminate the gross data in the original data first,then the MHSS ARAIM algorithm is used to deal with the data after the gross error detection.Therefore,this makes up for the weakness of the MHSS ARAIM algorithm.With the data processing and analysis from several international GNSS service(IGS)and international GNSS monitoring and assessment system(iGMAS)stations,the results show that this new algorithm is superior to MHSS ARAIM in the localizer performance with vertical guidance down to 200 feet service(LPV-200)when using GPS and BDS measure data.Under the assumption of a single-faulty satellite,the effective monitoring threshold(EMT)is improved about 22.47%and 9.63%,and the vertical protection level(VPL)is improved about 32.28%and 12.98%for GPS and BDS observations,respectively.Moreover,under the assumption of double-faulty satellites,the EMT is improved about 80.85%and 29.88%,and the VPL is improved about 49.66%and 18.24%for GPS and BDS observations,respectively. | Yabin ZHANG Li WANG Lihong FAN Xuanyu QU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，1： | 3 |
| 2 | Genetic polymorphisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese iron miners显示文摘 | Yabin Qu Yunxia Tang Duozhi Cao Fen Wu Jing Liu Guoliang Lu Zhongbin Zhang Zhaolin Xia | 2006 | International Journal of Hygiene and Environmental Health2006，，6： | 1 |
| 3 | Genetic polymor- phisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese Iron miners 显示文摘 | Qu Yabin Tang Yunxia Cao Duozhi | 2007 | Int J Hyg Environ Health2007，210，6： | 1 |
| 4 | Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients显示文摘Dear Editor,Omicron(B.1.1.529)was designated a variant of concern(VOC)on November 26,2021(Callaway,2021),and its subvariants BA.1,BA.2,and BA.3 emerged and circulated almost simultaneously(Desingu et al.,2022).BA.2 was more efficient in transmission and quickly overtook BA.1 to become the variant most frequently detected worldwide(Yamasoba et al.,2022a).Compared to the prototype SARS-CoV-2 spike protein(S),the BA.1 and BA.2 spike proteins harbor more than 30 mutations,of which 21 are identical between the two subvariants,while the BA.3 spike differs from BA.1 and BA.2 by 3 mutations in the receptor binding domain(RBD)(Fig.1A).More recently,BA.4 and BA.5(hereafter BA.4/5)emerged,sharing the same spike sequence and containing four additional mutations,Del69–70,L452R,F486V,and R493Q,compared with BA.2.BA.4/5 were detected first in South Africa and evolved independently of BA.2;they have spread widely and replaced BA.2 as the predominant VOC(Gruell et al.,2022b;Tegally et al.,2022).In addition,BA.2.75,derived from the BA.2 subvariant,harbors nine additional mutations in the spike protein compared with BA.2(Fig.1A).BA.4/5 and BA.2.75 have led to the continuous emergence of novel Omicron subvariants,including BF.7 and BQ.1.These new subvariants may be driving waves of pandemics. | Jun Chen Jing Yang Fangfang Chang Yabin Hu Qian Wu Shishan Teng Yongchen Liu Jian Zhang Rongzhang He Bo Liu Xingyu Zheng Ze Liu Yanxi Peng Zhenhua Xie Yuanfang Zhang Rui Lu Dong Pan You Wang Liting Peng Wenpei Liu Yi-Ping Li Xiaowang Qu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 5 | SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals显示文摘Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb)and B cell differentiation are tightly regulated by T follicular help (T_(FH)) cells. However, the longevity and functional role of T_(FH) cellsubsets in COVID-19 convalescents and vaccine recipients remain poorly defined. Here, we show that SARS-CoV-2 infection andinactivated vaccine elicited both spike-specific CXCR3^(+) T_(FH) cell and CXCR3^(-) T_(FH) cell responses, which showed distinct responsepatterns. Spike- specific CXCR3^(+) T_(FH) cells exhibit a dominant and more durable response than CXCR3^(-) T_(FH) cells that positivelycorrelated with antibody responses. A third booster dose preferentially expands the spike-specific CXCR3^(+) T_(FH) cell subset inducedby two doses of inactivated vaccine, contributing to antibody maturation and potency. Functionally, spike-specific CXCR3^(+) T_(FH) cellshave a greater ability to induce spike-specific antibody secreting cells (ASCs) differentiation compared to spike-specific CXCR3^(-) T_(FH)cells. In conclusion, the persistent and functional role of spike-specific CXCR3^(+) T_(FH) cells following SARS-CoV-2 infection andvaccination may play an important role in antibody maintenance and recall response, thereby conferring long-term protection. Thefindings from this study will inform the development of SARS-CoV-2 vaccines aiming to induce long-term protective immunememory. | Rongzhang He Xingyu Zheng Jian Zhang Bo Liu Qijie Wang Qian Wu Ziyan Liur Fangfang Chang Yabin Hu Ting Xie Yongchen Liu Jun Chen Jing Yang Shishan Teng Rui Lu Dong Pan You Wang Liting Peng Weijin Huang Velislava Terzieva Wenpei Liu Youchun Wang Yi-Ping Li Xiaowang Qu | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 6 | Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),theseventh coronavirus known to jump from intermediate hosts to humans,has resulted in a worldwide pandemic and caused immense economicdamage(Tan et al.,2020;Zhu et al.,2020).It is believed that coronavirus spillover may occur again in the future.Human exposure to a bat coro-navirus has been serologically confimed in a rural area of China,indi-cating that the coronavirus spillover occurred,although the origin andfrequency of spillovers are unclear(Wang et al.,2018). | Yabin Hu Jun Chen Jing Yang Zhanpeng Liu Xiaoyue Zhang Qian Wu Lulu Liu Shishan Teng Rongzhang He Bo Liu Xingyu Zheng Rui Lu Dong Pan You Wang Liting Peng Hongying chen Yi-Ping Li Wenpei Liu Xiaowang Qu | 2024 | Virologica Sinica2024，39，1： | 0 |
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