|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quantitative Assessment of Hepatic Fibrosis by Contrast-enhanced Ultrasonography显示文摘Objective To explore the contrast-enhanced ultrasonographic features for quantitative assessment of hepatic fibrosis. Methods 86 patients with chronic viral hepatitis B were enrolled in this study from March 2007 to August 2009. The patients were classified into 5 groups (S0-S4) according to fibrosis stage evaluated with ultrasound guided liver biopsy. New contrast-enhanced ultrasonography (CEUS) features including area under the time-intensity curve (TIC) of portal venous phase/hepatic arterial phase (Qp/Qa) and intensity of portal venous phase/hepatic arterial phase (Ip/Ia) were used to detect the blood supply ratio (portal vein/hepatic artery) in each group. Arrival time of portal vein trunk (Tp) and decreasing rate of TIC (β ) were also analyzed. Results Qp/Qa and Ip/Ia decreased from S0 to S4, while Tp and β increased. These 4 features were significantly correlated with the degree of fibrosis (P<0.001) and were significantly different among the five groups (P<0.001). Sensitivity and specificity of Ip/Ia were 80% and 86% for groups ≥S1, 75% and 86% for groups ≥ S2, 71% and 84% for groups ≥ S3, and 76% and 80% for group S4, respectively. Sensitivity and specificity of Qp/Qa were 70% and 88% for groups ≥ S1, 80% and 76% for groups ≥ S2, 74% and 70% for groups ≥ S3, and 81% and 95% for group S4, respectively. Conclusion Ip/Ia and Qp/Qa could be adopted as reliable, non-invasive features for quantitative assessment of hepatic fibrosis. | Ming-bo Zhang En-ze Qux En-ze Qu Ji-Bin Liu Jin-rui Wang | 2011 | Chinese Medical Sciences Journal2011，26，4： | 2 |
| 2 | SelectiveinhibitionofIL2mRNAblocksallograftrejectionbylimitingTcellclonalexpansion显示文摘 | TianL QuX WangME etal | 2001 | TransplantProc2001，33，12： | 1 |
| 3 | Properties of WCu composite powder produced by a thermo-mechanical method显示文摘 | LiYP QuX H ZhengZS | 2003 | International Journal of Refractory Metals and Hard Materials2003，21，： | 1 |
| 4 | Origin ofada- kitic intrusives generated during mid-Miocene east- west extension in southern Tibet 显示文摘 | HouZ Q Gao YF QuX M etal | 2004 | Earth and Planetary Science Letters2004，220，12： | 1 |
| 5 | TheresearchadvanceofFusariumwiltandVerticilliumwiltofcottoninChina(inChinese)显示文摘 | LiAG QuX YuXF | 2006 | 作物研究2006，20，1： | 1 |
| 6 | Identification, characterization, and functional study of the two novel human members of the semaphorin gene family显示文摘 | QuX Wei H Zhai Y | 2002 | J Biol Chem2002，277，： | 1 |
| 7 | CCAAT/Enhancer-Binding Proteins in Fibrosis:Complex Roles Beyond Conventional Understanding显示文摘CCAAT/enhancer-binding proteins(C/EBPs)are a family of at least six identified transcription factors that contain a highly conserved basic leucine zipper domain and interact selectively with duplex DNA to regulate target gene expression.C/EBPs play important roles in various physiological processes,and their abnormal function can lead to various diseases.Recently,accumulating evidence has demonstrated that aberrant C/EBP expression or activity is closely associated with the onset and progression of fibrosis in several organs and tissues.During fibrosis,various C/EBPs can exert distinct functions in the same organ,while the same C/EBP can exert distinct functions in different organs.Modulating C/EBP expression or activity could regulate various molecular processes to alleviate fibrosis in multiple organs;therefore,novel C/EBPs-based therapeutic methods for treating fibrosis have attracted considerable attention.In this review,we will explore the features of C/EBPs and their critical functions in fibrosis in order to highlight new avenues for the development of novel therapies targeting C/EBPs. | Lexun Wang Jiaojiao Feng Yanyue Deng Qianqian Yang Quxing Wei Dewei Ye Xianglu Rong Jiao Guo | 2023 | Research2023，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员