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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 3 | Management Strategies and Research Orientations of Forest Diseases and Pests in China显示文摘Forest diseases and pests are perceived as a growing hazard to China economy. It is a common conclusion that the actualities of forest pests in china are no effective measures to the old important pests, some secondary pests are ascending to chief pests, increasing devastation from exotic pests, frequent ecological pest eruption induced by environmental detriment and host-leading diseases to threaten the 'Western Development Project 'in China, which is the most important economical strategy to China; th... | ZHANG Xingyao LIANG Jun LU Quan YAN Donghui LUO Youqing XU Zhichun WEN Junbao1. Research Institute of Forest Ecology. Environment and Protection. Chinese Academy of Forestry. Beijing, 100091. P R China:2. College of Biological Sciences and Technology. Beiiine Forestry University. Beiiine. 100083. P R China | 2002 | Chinese Forestry Science and Technology2002，1，2： | 4 |
| 4 | 美国重症肌无力基金会关于重症肌无力临床试验的建议显示文摘由美国重症肌无力基金会(MGFA)的医学科学建议委员会(MSAB)组成工作组,于2010年在美国和2011年在意大利召开专家共识会议讨论重症肌无力(MG)临床试验的问题,与会代表包括来自美国和欧洲的神经科医生、统计学家、企业界代表、MG患者以及MGFA和欧洲重症肌无力协会的平民代表。 | Benatar M Sanders DB Burns TM Cutter GR Guptill JT Baggi F Kaminski HJ Mantegazza R Meriggioli MN Quan J Wolfe GI 李海峰(摘译) 高翔(摘译) | 2013 | 中国神经免疫学和神经病学杂志2013，20，1： | 2 |
| 5 | Involement of C - Abl tyrosine kinase in lipopolysaccharide- induced macrophage activation 显示文摘 | Le Quan Daniel R Chung S W | 1998 | J Immunnol1998，160，： | 2 |
| 6 | Accuracy of a novel automatic atrial capture threshold algorithm显示文摘 | Adler S 2nd Schaerf R Quan KJ | 2003 | PACE2003，26，： | 1 |
| 7 | Improved chilling tolerance by transformation with betA gene for the enhancement of glycinebetaine synthesis in maize显示文摘 | Quan R D Shang M Zhang H | 2004 | Plant Science2004，166，1： | 1 |
| 8 | Transcriptional regulation ofethylene response factor LeERF2 in the expression of ethylenebiosynthesis genes controls ethylene production in tomato andtobacco 显示文摘 | Zhang Z Zhang H Quan R | 2009 | Plant Physiol2009，150，1： | 1 |
| 9 | Stability kinetics of influenza vaccine coated onto microneedles during drying and storage显示文摘 | Kim Y C Quan F S Compans R W | 2011 | Pharm Res2011，28，1： | 1 |
| 10 | Improved chilling tolerance by transformation with betA gene for the enhancement of glycinebetaine synthesis in maize显示文摘 | QUAN R SHANG M ZHANG H | | 0，，： | 1 |
| 11 | EP2 receptor signaling pathways regulate classical activation of microglia显示文摘 | Quan Y Jiang J Dingledine R | 2013 | J Biol Chem2013，288，13： | 1 |
| 12 | ACORGA ZNX50- a new selective reagent for the solvent extraction ofzinc from chloride leach solutions显示文摘 | Dalton R F Burgess A Quan P M | 1992 | Hydrometallurgy1992，30，13： | 1 |
| 13 | Numerical simulation of long rods impacting silicon carbide targets using J H-1 model显示文摘 | Quan X Clegg R A Cowler M S | 2006 | International Journal of Impact Engineering2006，33，112： | 1 |
| 14 | Paraquat neurotoxicity is distinct from that of MPTP and rotenone显示文摘 | Richardson J R Quan Y Sherer T B | 2005 | Toxicol Sci2005，88，1： | 1 |
| 15 | Role of nucleotides in intestinal develop- ment and repair: implications for infant nutrition显示文摘 | Uauy R Quan R Gil A | 1994 | Nutr1994，，： | 1 |
| 16 | Preparation of graded zirconia hydroxyapatite composite bioceramic and its immunocompatibility in vitro显示文摘 | Quan R Yang D Miao X | 2007 | J Biomater Appl2007，22，2： | 1 |
| 17 | Superhard Monoclinic Polymorph of Carbon 显示文摘 | LI Quan MA Yan-ming Oganov A R | 2009 | Phys Rev Lett2009，102，17： | 1 |
| 18 | Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial显示文摘 | BRESALIER R S SANDLER R S QUAN H | 2005 | N Engl J Med2005，352，11： | 1 |
| 19 | Renal replacement therapy and acute renal failure显示文摘 | Quan A Quigley R | 2005 | Curr Opln Pedlatr2005，17，2： | 1 |
| 20 | Endothelial dysfunction in obstructive sleep apnea显示文摘 | Budhiraja R Parthasarathy S Quan SF | | 0，，： | 1 |
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