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| 1 | Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells显示文摘增加的证据被积累了在肿瘤开始显示 epigenetic 规定的重要角色。以前,我们观察到病毒核心(HCVc ) 蛋白质导致了的丙肝的 transfection 在正常胆汁的房间的恶意的转变,和那肿瘤 suppressor 基因 RASSF1A 是在由在倡导者区域的 hypermethylation 的许多 hilar cholangiocarcinoma 病人的 downregulated。在现在的学习,我们发现集合和 MYND 包含域的蛋白质 3 (SMYD3 ) ,新奇 histone methyltransferase,在有 HCV 感染的那些特别是在 cholangiocarcinoma 病人的 overexpressed。进 hilar cholangiocarcinoma 房间的 HCVc 的 Transfection 衬里 QBC939 和 FRH0201 能 upregulate SMYD3 的表示并且支持房间生长,它与我们的临床的研究的结果一致。这现象显示 SMYD3 与有 HCV 感染的 cholangiocarcinoma 开始的 epigenetic 规定有关。SMYD3 的 Overexpression 能禁止 RASSF1A 表示,而由 siRNA 的 SMYD3 的抑制改进了它的表示。Methylation 特定的聚合酶链反应(MS-PCR ) 结果证明 RASSF1A 倡导者的 methylation 地位被 SMYD3 调整。在结论, HCVc 能 upregulate 通过 SMYD3 的规定的 RASSF1A 倡导者的 methylation 地位,和 histone methylation 可以由未知机制影响下游的基因的 DNA methylation。 | Ning Guo Rufu Chen Zhihua Li Yonggang Liu Di Cheng Quanbo Zhou Jiajia Zhou Qing Lin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 8 |
| 2 | Universal Delayed Kalman Filter with Measurement Weighted Summation for the Linear Time Invariant System显示文摘 | GE Quanbo XU Tingliang FENG Xiaoliang WEN Chenglin | 2011 | Chinese Journal of Electronics2011，20，1： | 8 |
| 3 | Kalman Filtering in a Sensor Bandwidth Constrained Network显示文摘 | WEN Chenglin WEN Chenglin GE Quanbo GE Quanbo TANG Xianfeng TANG Xianfeng | 2009 | Chinese Journal of Electronics2009，18，4： | 6 |
| 4 | HYBRID FILTER WITH PREDICT-ESTIMATOR AND COMPENSATOR FOR THE LINEAR TIME INVARIANT DELAYED SYSTEM显示文摘This paper investigates the problem of real-time estimation for one kind of linear time invariant systems which subject to limited communication capacity. The communication limitations include signal transmission delay, the out-of-sequence measurements and data packet dropout, which appear typically in a network environment. The kernel of filter design is equally to formularize the traditional Kalman filter as one linear weighted summation which is composed of the initial state estimate and all sequential sampled measurements. For it can adapt aforementioned information limitations, the linear weighted summation is then decomposed into two stages. One is a predict-estimator composed by all reached measurements, another is one compensator constructed by those time-delayed data. In the network environment, there are obvious differences between the new hybrid filter and those existing delayed Kalman filters. For example, the novel filter can be optimal in the sense of linear minimum mean square error as soon as all measurements available and has the lowest running time than these existing delayed filters. One simulation, including two cases, is utilized to illustrate the design procedures proposed in this paper. | Wen Chenglin Ge Quanbo Feng Xiaoliang | 2009 | Journal of Electronics(China)2009，26，5： | 5 |
| 5 | Opinion dynamics in finance and business: a literature review and research opportunities显示文摘Opinion dynamics is an opinion evolution process of a group of agents,where the final opinion distribution tends to three stable states:consensus,polarization,and fragmentation.At present,the opinion dynamics models have been extensively studied in differrent fields.This paper provides a review of opinion dynamics in finance and business,such as,finance,marketing,e-commerce,politics,and group decision making.Furthermore,identified research challenges have been proposed to promote the future research of this topic. | Quanbo Zha Gang Kou Hengjie Zhang Haiming Liang Xia Chen Cong‑Cong Li Yucheng Dong | 2020 | Financial Innovation2020，6，1： | 5 |
| 6 | Radical nerve dissection for the carcinoma of head of pancreas: report of 30 cases显示文摘Objective: To explore the clinical value of the radical nerve dissection(RND) for the carcinoma of head of pancreas(CHP). Methods: The clinical and pathological data of 30 CHP patients who underwent RND in our hospital were retrospectively analyzed, with an attempt to explore the safety and short-term efficacy of this procedure. Results: Among these 30 patients, the operative time was(351±61) min, the intra-operative blood loss was 350(range, 300–600) m L, and the grades B and C pancreatic fistula was 23.33%. During the follow-up(range, 2-30 months; median: 17 months), the 1-year survival rate was 63.33% and the 1-year disease-free survival rate was 56.67%. Among the 23 patients(76.66%) with positive extra-pancreatic perineural invasion(PNI), the 1-year casefatality rate was 34.78%, which was not significantly different from that(28.57%) of patients with negative PNI(P=0.760). Conclusions: Our results suggested potential advantages of RND in the fields of surgery-associated risk and prognosis compared with the Whipple operation in the treatment of CHP. Due to the low sample size of this study, further well-designed research of large sample size is needed. | Qing Lin Langping Tan Yu Zhou Quanbo Zhou Rufu Chen | 2016 | Chinese Journal of Cancer Research2016，28，4： | 4 |
| 7 | THE RESEARCH OF GRADATION FUSION ALGORITHM BASED ON MULTISENSOR ASYNCHRONOUS SAMPLING SYSTEM显示文摘This letter explores the distributed multisensor dynamic system, which has uniform sampling velocity and asynchronous sampling data for different sensors, and puts forward a new gradation fusion algorithm of multisensor dynamic system. As the total forecasted increment value between the two adjacent moments is the forecasted estimate value of the corresponding state increment in the fusion center, the new algorithm models the state and the forecasted estimate value of every moment. Kalman filter and all measurements arriving sequentially in the fusion period are employed to update the evaluation of target state step by step, on the condition that the system has obtained the target state evaluation that is based on the overall information in the previous fusion period. Accordingly, in the present period, the fusion evaluation of the target state at each sampling point on the basis of the overall information can be obtained. This letter elaborates the form of this new algorithm. Computer simulation demonstrates that this new algorithm owns greater precision in estimating target state than the present asynchronous fusion algorithm calibrated in time does. | Wen Chenglin Zhang Liantang Ge Quanbo | 2005 | Journal of Electronics(China)2005，22，5： | 3 |
| 8 | OPTIMAL DISTRIBUTED FUSION ALGORITHM WITH ONE-STEP OUT-OF-SEQUENCE ESTIMATES显示文摘The transmission modes of multi-hop and broadcasting for Wireless Sensor Networks(WSN)often make random and unknown transmission delays appear,so multisensor data fusion based ondelayed systems attracts intense attention from lots of researchers.The existing achievements for thedelayed fusion all focus on Out-Of-Sequence Measurements(OOSM)problem which has many dis-advantages such as high communication cost,low computational efficiency,huge computational com-plexity and storage requirement,bad real-time performance and so on.In order to overcome theseproblems occurred in the OOSM fusion,the Out-Of-Sequence Estimates(OOSE)are considered tosolve the delayed fusion for the first time.Different from OOSM which belongs to the centralized fusion,the OOSE scheme transmits local estimates from local sensors to the central processor and is thus thedistributed fusion;thereby,the OOSE fusion can not only avoid the problems suffered in the OOSMfusion but also make the design of fusion algorithm highly simple and easy.Accordingly,a novel optimallinear recursive prediction weighted fusion method is proposed for one-step OOSE problem in this letter.As a tradeoff,its fusion accuracy is slightly lower than that of the OOSM method because the currentOOSM fusion is a smooth estimate and OOSE gets a prediction estimate.But,the smooth result of theOOSE problem also has good fusion accuracy.Performance analysis and computer simulation show thatthe total performance of the proposed one-step OOSE fusion algorithm is better than the current one-step OOSM fusion in the practical tracking systems. | Ge Quanbo Wen Chenglin | 2008 | Journal of Electronics(China)2008，25，4： | 3 |
| 9 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 10 | Networked Kalman filtering with combined constraints of bandwidth and random delay显示文摘Kalman filter is a powerful tool in target tracking and self-localization across wireless sensor networks with many constraints.This paper considers the filters design for networked systems with combined constraints of bandwidth and random delay,and proposes a kind of universal networked Kalman estimator for given linear time invariant(LTI) or determinate parameters(DP) systems,which are also called linear and determinate parameters(LDP) systems jointly.Firstly,two modeling ways to treat bit quantization error vector are given and the corresponding LDP systems taken after bit quantization are established.Secondly,we introduce an equivalent weighted summation form of the conventional linear Kalman filter,which fully uses two essential characteristics,namely offline computation property from the LDP systems and linear weighted summation property from the linear minimum mean square error estimate.Finally,by adopting the replacement and innovation compensation operations,a kind of integrated networked estimator,involving two estimation algorithms with different modeling ways to bit quantization error actually,is presented based on the weighted summation filter for random delay systems.The proposed universal networked estimation algorithms have some outstanding advantages such as extensive application,concise algorithm structure,high estimate accuracy,and good running performance.Several examples are demonstrated to validate the proposed networked estimation algorithms. | GE QuanBo WEN ChengLin XU TingLiang | 2012 | Science China(Information Sciences)2012，55，10： | 3 |
| 11 | Neutrophils in cancer—unresolved questions显示文摘There is growing recognition that neutrophils play an important role in cancer initiation, progression and metastasis. Although they are typically characterized as short-lived effector cells, neutrophils have been shown to acquire immunosuppressive and pro-tumorigenic functions that promote tumor progression and escape. As such, inhibition of their function or depletion of neutrophils are being explored as potential cancer therapies. However, growing evidence of neutrophil diversification in cancer and their potential anti-tumor roles raise many unresolved questions. Here, we review recent advances that address the definition,origin and function of neutrophils in cancer, and elaborate on obstacles that make the study of neutrophils challenging. We envision that this review will provide the groundwork for focused design of therapeutics that will specifically target 'tumorreprogrammed' neutrophils while sparing normal neutrophils to improve patient outcomes. | Melissa S.F.Ng Leonard Tan Quanbo Wang Charles R.Mackay Lai Guan Ng | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 12 | Trace Amounts of Triple-Functional Additives Enable Reversible Aqueous Zinc-Ion Batteries from a Comprehensive Perspective显示文摘Although their cost-effectiveness and intrinsic safety,aqueous zinc-ion batteries suffer from notorious side reactions including hydrogen evolution reaction,Zn corrosion and passivation,and Zn dendrite formation on the anode.Despite numerous strategies to alleviate these side reactions have been demonstrated,they can only provide limited performance improvement from a single aspect.Herein,a triple-functional additive with trace amounts,ammonium hydroxide,was demonstrated to comprehensively protect zinc anodes.The results show that the shift of electrolyte pH from 4.1 to 5.2 lowers the HER potential and encourages the in situ formation of a uniform ZHS-based solid electrolyte interphase on Zn anodes.Moreover,cationic NH^(4+)can preferentially adsorb on the Zn anode surface to shield the“tip effect”and homogenize the electric field.Benefitting from this comprehensive protection,dendrite-free Zn deposition and highly reversible Zn plating/stripping behaviors were realized.Besides,improved electrochemical performances can also be achieved in Zn//MnO_(2)full cells by taking the advantages of this triple-functional additive.This work provides a new strategy for stabilizing Zn anodes from a comprehensive perspective. | Ruwei Chen Wei Zhang Quanbo Huang Chaohong Guan Wei Zong Yuhang Dai Zijuan Du Zhenyu Zhang Jianwei Li Fei Guo Xuan Gao Haobo Dong Jiexin Zhu Xiaohui Wang Guanjie He | 2023 | Nano-Micro Letters2023，15，6： | 2 |
| 13 | Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism显示文摘 | Yu Zhou Quanbo Zhou Qing Lin Ruiwan Chen Yuanfeng Gong Yimin Liu Min Yu Bing Zeng Kaiwen Li Rufu Chen Zhihua Li | 2013 | Int J Cancer2013，，8： | 1 |
| 14 | Alkylamides from pericarps of Zanthoxylum bungeanum 显示文摘 | Quanbo Xiong Dawei Shi Hirofumi Yamamoto | 1997 | Phytochemistry1997，46，6： | 1 |
| 15 | Hepatoprotective effect of Apocynum venetum and its active con- stituents显示文摘 | XIONG Quanbo FAN Wenzhe YOKOZAW T | 2000 | Planta Med2000，66，2： | 1 |
| 16 | DGP1,a drought-induced guard cell-specific promoter and its function analysis in tobacco plants显示文摘The genetic regulation of stomatal movement mainly depends on an efficient control system of gene expression, and guard cell-specific promoter is becoming the best choice. Here we combined the dehydration responsive element (DRE) with guard cell specific element (GCSE) to construct a novel promoter, DGP1. Histochemical assays in transgenic tobacco carrying β -glucuronidase (gus) gene fused to DGP1 demonstrated that GUS activity was found to be highly inducible by drought treatment and specifically restricted to guard cells. No GUS activity was detected in roots, stems or flowers after treatment. Further quantitative analysis showed that GUS activity in the epidermal strips was apparently induced by dehydration and dramatically increased with the elongation of treatment. The GUS activity after 8 h treatment was 179 times that of those without treatment. Although GUS activity in roots, stems or mesophyll increased after treatment, no great changes were observed. These results suggested that DGP1 could drive target gene expressed in guard cells when plant is subjected to drought stress. And this gets us prepared to control opening and closing of stomata through plant gene engineering. | LI Jun GONG Ximing LIN Huiqiong SONG Quanbo CHEN Jia WANG Xuechen | 2005 | Science China(Life Sciences)2005，48，2： | 1 |
| 17 | Design and fabrication of silicon condenser microphone using corrugated diaphragm technique显示文摘 | Zou Quanbo | 1996 | Journal of microelectromechanical s ystems vol 5 No 3 September 19961996，5，3： | 1 |
| 18 | Effects of porous clay ceramic rates on aeration porosity characteristics in a structurally degraded soil under greenhouse vegetable production显示文摘Soil structure degradation in greenhouse vegetable fields reduces vegetable production. Increasing aeration porosity is the key to ameliorating soil structure degradation. Thus, we tested the effect of a porous material, porous clay ceramic(PLC), on the amelioration of soil structure degradation under greenhouse vegetable production. A 6-month pot experiment was conducted with four PLC application levels based on volume, i.e., 0%(control), 5%(1 P), 10%(2 P), and15%(3 P) using Brassica chinensis as the test plant. At the end of the experiment, soil columns were sampled, and the aeration pore network was reconstructed using X-ray computed tomography(CT). The degree of anisotropy(DA), fractal dimension(FD), connectivity, aeration porosity, pores distribution, and shape of soil aeration pores and plant biomass were determined. The DA, FD, and connectivity did not significantly differ as the PLC application rate increased.Nonetheless, aeration porosity significantly linearly increased. The efficiency of PLC at enhancing soil aeration porosity was 0.18% per Mg ha^(-1). The increase in aeration porosity was mainly due to the increase in pores > 2 000 μm, which was characterized by irregular pores. Changes in aeration porosity enhanced the production of B. chinensis. The efficiency of PLC at increasing the plant fresh weight was 0.60%, 3.06%, and 2.12% per 1% application rate of PLC for the 1 P, 2 P, and 3 P treatments, respectively. These results indicated that PLC is a highly efficient soil amendment that improves soil structure degradation by improving soil aeration under greenhouse conditions. Based on vegetable biomass, a 10% application rate of PLC was recommended. | Quanbo YU Meiyan WANG Yutian TIAN Xuezheng SHI Xiangwei LI Lingying XU Xinqiao XIE Yijie SHI Yuncong ZHU | 2021 | Pedosphere2021，31，4： | 1 |
| 19 | Antioxidative effects of phenylethanoids from Cistanche deserticola显示文摘 | Quanbo X Shigetoshi K Tadato T | 1996 | Biol Pharm Bull1996，19，12： | 1 |
| 20 | Inhibition of nitric oxide by phenylethanoids in activated macrophages显示文摘 | Quanbo Xiong Yasuhiro Tezuka Takuji Kaneko | 2000 | European J Pharmacol2000，400，1： | 1 |
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