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| 1 | Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells显示文摘增加的证据被积累了在肿瘤开始显示 epigenetic 规定的重要角色。以前,我们观察到病毒核心(HCVc ) 蛋白质导致了的丙肝的 transfection 在正常胆汁的房间的恶意的转变,和那肿瘤 suppressor 基因 RASSF1A 是在由在倡导者区域的 hypermethylation 的许多 hilar cholangiocarcinoma 病人的 downregulated。在现在的学习,我们发现集合和 MYND 包含域的蛋白质 3 (SMYD3 ) ,新奇 histone methyltransferase,在有 HCV 感染的那些特别是在 cholangiocarcinoma 病人的 overexpressed。进 hilar cholangiocarcinoma 房间的 HCVc 的 Transfection 衬里 QBC939 和 FRH0201 能 upregulate SMYD3 的表示并且支持房间生长,它与我们的临床的研究的结果一致。这现象显示 SMYD3 与有 HCV 感染的 cholangiocarcinoma 开始的 epigenetic 规定有关。SMYD3 的 Overexpression 能禁止 RASSF1A 表示,而由 siRNA 的 SMYD3 的抑制改进了它的表示。Methylation 特定的聚合酶链反应(MS-PCR ) 结果证明 RASSF1A 倡导者的 methylation 地位被 SMYD3 调整。在结论, HCVc 能 upregulate 通过 SMYD3 的规定的 RASSF1A 倡导者的 methylation 地位,和 histone methylation 可以由未知机制影响下游的基因的 DNA methylation。 | Ning Guo Rufu Chen Zhihua Li Yonggang Liu Di Cheng Quanbo Zhou Jiajia Zhou Qing Lin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 8 |
| 2 | Radical nerve dissection for the carcinoma of head of pancreas: report of 30 cases显示文摘Objective: To explore the clinical value of the radical nerve dissection(RND) for the carcinoma of head of pancreas(CHP). Methods: The clinical and pathological data of 30 CHP patients who underwent RND in our hospital were retrospectively analyzed, with an attempt to explore the safety and short-term efficacy of this procedure. Results: Among these 30 patients, the operative time was(351±61) min, the intra-operative blood loss was 350(range, 300–600) m L, and the grades B and C pancreatic fistula was 23.33%. During the follow-up(range, 2-30 months; median: 17 months), the 1-year survival rate was 63.33% and the 1-year disease-free survival rate was 56.67%. Among the 23 patients(76.66%) with positive extra-pancreatic perineural invasion(PNI), the 1-year casefatality rate was 34.78%, which was not significantly different from that(28.57%) of patients with negative PNI(P=0.760). Conclusions: Our results suggested potential advantages of RND in the fields of surgery-associated risk and prognosis compared with the Whipple operation in the treatment of CHP. Due to the low sample size of this study, further well-designed research of large sample size is needed. | Qing Lin Langping Tan Yu Zhou Quanbo Zhou Rufu Chen | 2016 | Chinese Journal of Cancer Research2016，28，4： | 4 |
| 3 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 4 | Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism显示文摘 | Yu Zhou Quanbo Zhou Qing Lin Ruiwan Chen Yuanfeng Gong Yimin Liu Min Yu Bing Zeng Kaiwen Li Rufu Chen Zhihua Li | 2013 | Int J Cancer2013，，8： | 1 |
| 5 | Fuzzy Set-Based Risk Evaluation Model for Real Estate Projects 显示文摘 | Yijian Sun Rufu Huang Dailin Chen | 2008 | Tsinghua Science & Technology2008，，1： | 1 |
| 6 | Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism显示文摘 | Yu Zhou Quanbo Zhou Qing Lin Ruiwan Chen Yuanfeng Gong Yimin Liu Min Yu Bing Zeng Kaiwen Li Rufu Chen Zhihua Li | 2013 | Int. J. Cancer2013，，8： | 1 |
| 7 | Fuzzy Set - Based Risk Evaluation Model for Real Estate Projects 显示文摘 | Sun Yijian Huang Rufu Chen Dailin Li Hongnan | 2008 | Tsinghua Science and Technology2008，1，13： | 1 |
| 8 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 9 | Gemcitabine Compared With Gemcitabine and S-1 Combination Therapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis显示文摘 | Doudou Li Changhao Chen Yu Zhou Rufu Chen Xinxiang Fan Zhuofei Bi Zhihua Li Yimin Liu | 2015 | Medicine2015，，35： | 1 |
| 10 | A novel clinical model for risk prediction and stratification of new-onset diabetes mellitus after distal pancreatectomy显示文摘Background:The incidence of new-onset diabetes mellitus(NODM)after distal pancreatectomy(DP)remains high.Few studies have focused on NODM in patients with pancreatic benign or low-grade malignant lesions(PBLML).This study aimed to develop and validate an effective clinical model for risk prediction and stratification of NODM after DP in patients with PBLML.Methods:A follow-up survey was conducted to investigate NODM in patients without preoperative DM who underwent DP.Four hundred and forty-eight patients from Peking Union Medical College Hospital(PUMCH)and 178 from Guangdong Provincial People’s Hospital(GDPH)met the inclusion criteria.They constituted the training cohort and the validation cohort,respectively.Univariate and multivariate Cox regression,as well as least absolute shrinkage and selection operator(LASSO)analyses,were used to identify the independent risk factors.The nomogram was constructed and verified.Concordance index(C-index),receiver operating characteristic(ROC)curve,calibration curves,and decision curve analysis(DCA)were applied to assess its predictive performance and clinical utility.Accordingly,the optimal cut-off point was determined by maximally selected rank statistics method,and the cumulative risk curves for the high-and low-risk populations were plotted to evaluate the discrimination ability of the nomogram.Results:The median follow-up duration was 42.8 months in the PUMCH cohort and 42.9 months in the GDPH cohort.The postoperative cumulative 5-year incidences of DM were 29.1%and 22.1%,respectively.Age,body mass index(BMI),length of pancreatic resection,intraoperative blood loss,and concomitant splenectomy were significant risk factors.The nomogram demonstrated significant predictive utility for post-pancreatectomy DM.The C-indexes of the nomogram were 0.739 and 0.719 in the training and validation cohorts,respectively.ROC curves demonstrated the predictive accuracy of the nomogram,and the calibration curves revealed that prediction results were in general agreement with the actual results.The considerable clinical applicability of the nomogram was certified by DCA.The optimal cut-off point for Background:The incidence of new-onset diabetes mellitus(NODM)after distal pancreatectomy(DP)remains high.Few studies have focused on NODM in patients with pancreatic benign or low-grade malignant lesions(PBLML).This study aimed to develop and validate an effective clinical model for risk prediction and stratification of NODM after DP in patients with PBLML.Methods:A follow-up survey was conducted to investigate NODM in patients without preoperative DM who underwent DP.Four hundred and forty-eight patients from Peking Union Medical College Hospital(PUMCH)and 178 from Guangdong Provincial People’s Hospital(GDPH)met the inclusion criteria.They constituted the training cohort and the validation cohort,respectively.Univariate and multivariate Cox regression,as well as least absolute shrinkage and selection operator(LASSO)analyses,were used to identify the independent risk factors.The nomogram was constructed and verified.Concordance index(C-index),receiver operating characteristic(ROC)curve,calibration curves,and decision curve analysis(DCA)were applied to assess its predictive performance and clinical utility.Accordingly,the optimal cut-off point was determined by maximally selected rank statistics method,and the cumulative risk curves for the high-and low-risk populations were plotted to evaluate the discrimination ability of the nomogram.Results:The median follow-up duration was 42.8 months in the PUMCH cohort and 42.9 months in the GDPH cohort.The postoperative cumulative 5-year incidences of DM were 29.1%and 22.1%,respectively.Age,body mass index(BMI),length of pancreatic resection,intraoperative blood loss,and concomitant splenectomy were significant risk factors.The nomogram demonstrated significant predictive utility for post-pancreatectomy DM.The C-indexes of the nomogram were 0.739 and 0.719 in the training and validation cohorts,respectively.ROC curves demonstrated the predictive accuracy of the nomogram,and the calibration curves revealed that prediction results were in general agreement with the actual results.The considerable clinical applicability of the nomogram was certified by DCA.The optimal cut-off point for risk prediction value was 2.88, and the cumulative risk curves of each cohort showed significant differences between the high- and low-risk groups. Conclusions: The nomogram could predict and identify the NODM risk population, and provide guidance to physicians in monitoring and controlling blood glucose levels in PBLML patients after DP. | Zhihong Chen Ning Shi Cheng Xing Yiping Zou Yuanpeng Zhang Zhenrong Chen Fan Wu Haosheng Jin Rufu Chen Menghua Dai | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
| 11 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 12 | Research on Visual Virtual Design Platform for NC Machine Tools显示文摘The fundamental ideas on building the collaborative design platform of virtual visualization for NC machine tools are introduced. The platform is based on the globally shared product model conforming to the STEP Standard,and used PDM system to integrate and encapsulate CAD/CAE and other application software for the product development. The platform also integrated the expert system of NC machine tools design,analysis and estimation. This expert system utilized fuzzy estimation principle to evaluate the design and simulation analysis results and make decisions. The platform provides the collaborative intelligent environment for the design of virtual NC machine tools prototype aiming at integrated product design team. It also supports the customized development of NC machine tools. | HU Rufu 1,2 ,CHEN Xiaoping1,SUN Qinghong2 (1.School of Transportation and Traffic,Ningbo University of Technology,Ningbo 315016,China 2.Department of Mechanical Engineering,Southeast University,Nanjing 210096,China) | 2006 | 武汉理工大学学报2006，28，S1： | 0 |
| 13 | Studies on In Vitro Slow-Release Characteristics and Anticancer Effect of 5-Fluorouracil-Loaded Immuno-Nanoparticles显示文摘OBJECTIVE To investigate slow-release features of biodegradable anticancer 5-fluorouracil-loaded immunonanoparticles (5-FU INPs), and to assess their tumor cell killing activity in vitro. METHODS The method of vibrating dialysis at a constant temperature, and first-order derivative ultraviolet spectrophotometry were used to deter- mine the drug-releasing character of 5-FU INPs. The methyl thiazolyl tetrazo- lium (MTT) colorimetric method was employed to assay the killing activity of 5-FU INPs on 5 tumor cell lines at different phases. RESULTS The 5-FU INPs had a favorable slow-release function, with a ot1n/2 r5e lteuamseo rt icmeell olifn 1e0s. 4re dsauyltsin. gT hine 5a- FpUos IiNtivPes choardre ala rtaivtihtye rb setrtwonege nle tthhael keiflfleincgt activity and the action time and amount of the drug released. CONCLUSION The drug disposition is uniform from the 5-FU INPs, and there is no impact on efficacy of the 5-FU during preparation and degra- dation of the 5-FU INPs. The 5-FU INPs have a favorable function for drug release, and can maintain an effective killing activity over a long period of time. | Kaihong Huang Jianhua Liu Lingyun Wang Zhaohua Zhu Qikui Chen Jun Min Rufu Chen | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 0 |
| 14 | Splenic autotransplantation and oesophageal transection anastomosis in patients with portal hypertension (26 years clinical observation)显示文摘The surgical treatment methods for cirrhosis patients complicated with portal hypertension are complicated.In this study,we evaluated the effectiveness of a new treatment strategy:splenic auto-transplantation and oesophageal transection anastomosis on 274 patients from three aspects:clinical observation,splenic immunology and portal dynamics.From 1979 to 2005,274 cirrhosis patients with portal hypertension who underwent the new treatment strategy were followed up to observe different clinical indexes,which were then compared with those of the traditional surgery treatment.From 1999 to 2002,a randomized control trial(RCT)was performed on 40 patients to compare their immune function after operation.From 1994 to 2004,another RCT was carried out on 28 patients to compare the portal dynamics through three-dimensional dynamic contrast enhanced MR angiography(3D DEC MRA)investigation after operation.Among 274 patients(mean age 41.8 years),the emergency operative mortality(4.4%),selective operative mortality(2.2%),complication rate(17.9%),morbidity of hepatic encephalopathy(<1%),bleeding rate of portal hypertension gastritis(PHG)(9.1%),and morbidity of hepatic carcinoma(8%)were similar to those under traditional operation;the spleen immunology function(Tuftsin,IgM)decreased among the groups 2 months after operation.Through 3D DCE MRA,the cross section area,the velocity and volume of blood flow of main portal vein decrease significantly after operation in both groups,the auto transplantation group was significantly lower in velocity and volume of blood flow than in the control group.Splenic auto transplantation and esophageal transection anastomosis are a safe,effective,and reasonable treatment strategy for portal hypertension with varicial bleeding.It can not only correct hypersplenism but also completely stanch blood,and auto transplanted spleen in the retroperitoneal space can preserve immune function and establish abroad collateral circulation. | CHEN Jisheng HUO Jinshan ZHANG Hongwei SHANG Changzhen CHEN Rufu ZHANG Jie Obetien Mapudengo CHEN Yajin ZHANG Lei | 2007 | Frontiers of Medicine2007，1，1： | 0 |
| 15 | Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis显示文摘Introduction The dissemination of cancer cells to organs initiates the formation of an aggressive cancer phenotype and is a predominant cause of cancer-associated death.For most epithelial cancers,lymphatic system metastasis has been characterized as the most common and earliest metastatic pathway,and the detection of metastasis in lymph nodes(LNs)often predicts poor survival among patients'.Although increasing attention is being paid to the clinical importance of LN metastasis,the underlying mechanisms have remained unclear in the past decade.Accumulating evidence suggests that the occurrence of LN metastasis is not stochastic but is a programming biological event regulated by the bidirectional crosstalk between metastasis-initiating cancer cells and the tumor microenvironment(TME)2.However,the regulators and patterns of cancer-TME communication in LN metastasis remain to be furtherexplored. | Changhao Chen Yuming Luo Hanhao Zheng Dingwen Zhang Yao Kong Jiabin Yang Mingjie An Yan Lin Daowei Lin Rufu Chen | 2023 | Cancer Biology & Medicine2023，20，3： | 0 |
| 16 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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