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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 3 | Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species显示文摘Objective:To evaluate the antiasthmatic and antitussive properties of the aqueous leaf extract of Bryophyilum pinnatum {B.pinnatum)(BP) Lam.Methods:Ovalbiunin-sensilized guinea pigs which were treated with BP for 21 consecutive days were exposed to 0.2%histamine aerosol in a glass chamber.Mucus viscosity,white blood cell and lymphocyte counts and tracheal wall morphometry were measured.Bouts of cough were counted pre and post acute exposure of extract-treated(X7 d) guinea pigs to 7.5%citric acid aerosol in a chamber.Phenol red expectoration was estimated in mice after 7 d of daily administration of BP.Results:Doses of 200 and 400 mg/kg/day(×21 d) BP significantly increased the time for guinea pigs to experience preconvulsive dyspnoea.BP and salbutamol(0.5 mg/kg/day×21 d) reduced mucus viscosity in the sensitized group to values comparable with controls.White blood cell,lymphocyte counts and tracheal morphometry were not significantly altered.Both doses of BP also significantly reduced the bouts of cough but only 400 mg/kg/day significantly inhibited the amount of phenol red secreted.Conclusions:BP has demonstrated antiasthmatic and antitussive properties in these rodent models.These properties may underscore its use in Nigerian ethnomedicine. | Edward O Salami Raymond I Ozolua Stephen O Okpo Gerald I Eze Dickson O Uwaya | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 2 |
| 4 | Outcome of postradiation osteosarcoma does not correlate with chemotherapy response显示文摘 | LEWIS V O RAYMOND K MIRZA A N | 2006 | C/in Orthop Related Res2006，450，： | 1 |
| 5 | Age at onset as a factorin determining the phenotype of primary torsion dystonia显示文摘 | O'Riordan S Raymond D Lynch T | 2004 | Neurology2004，63，8： | 1 |
| 6 | Revisiting the predictive validity of emotional intelligence: self-report versus ability-based measures显示文摘 | Raymond M O Connor J Ian S L | 2003 | Personality and In- dividual Differences2003，35，8： | 1 |
| 7 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 8 | Pyrite composition and ore genesis in the Prince Lyell copper deposit, Mt Lyell mineral field, western Tasmania, Australia 显示文摘 | O L Raymond | 1996 | Ore Geology Reviews1996，，10： | 1 |
| 9 | Draft1 , a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation 显示文摘 | Raymond C S Murphy M W O'Sullivan M G etal | 2000 | Genes Dev2000，14，20： | 1 |
| 10 | Pyrite composition and ore genesis in the Prince Lyell copper deposit,Mt Lyell mineral field,Western Tasmania,Australia显示文摘 | Raymond O L | 1996 | Ore Geology Reviews1996，10，： | 1 |
| 11 | Biorthogonal wavelet space:Parametrization and factorization 显示文摘 | Howard L Jun T Raymond O | 2001 | Society for Industrial and Applied Mathematics2001，33，1： | 1 |
| 12 | Pyrite composition and ore genesis in the Prince Lyell copper deposit,Mt Lyell mineral field,westernTasmania,Australia显示文摘 | Raymond O L | 1996 | Ore Geology Reviews1996，10，36： | 1 |
| 13 | Transforaminal endoscopic surgery for symptomatic lumbar disc herniations:a systematic review of the literature显示文摘 | Jorm N Raymond O Ronald B | | 0，，： | 1 |
| 14 | Composite pseudolink end-point control of flexible manipulators 显示文摘 | King Joel O Gourishankar V G Rink Raymond E | 1990 | IEEE Transactions on Systems Man and Cybernetics1990，20，5： | 1 |
| 15 | Tinkering with the C- Function: A Molecular Frmne for the Selection of Double Flowers in Cultivated Roses 显示文摘 | Dubois A Raymond O Maene M e! al | 2010 | Plos One2010，5，2： | 1 |
| 16 | Unruptured intracranial aneurysms: why we must not perpetuate the impasse for another 25 years显示文摘 | Naggara O Darsaut T Trystram D Tselikas L Raymond J | 2014 | Lancet Neurol2014，13，： | 1 |
| 17 | Tinkering with the C function: a molecular frame for the selection of double flowers in cultivated roses显示文摘 | Dubois A Raymond O Maene M | 2010 | PLoS One2010，5，2： | 1 |
| 18 | New monoclonal antibodies identify the glycoprotein carrying the CA125 epitope 显示文摘 | O Brien TJ Raymond LM Bannon GA | 1991 | Am J Obstet Gynecol1991，165，61： | 1 |
| 19 | The persistence and degradation of chlorothalonil and chlorpyrifos in a cranberry bog显示文摘 | Raymond A Putnam Judd O Nelson J Marshall Clark | 2003 | Joumal of Agricultural and Food Chemistry2003，51，1： | 1 |
| 20 | Up‐regulation of crystallins is involved in the neuroprotective effect of wolfberry on survival of retinal ganglion cells in rat ocular hypertension model显示文摘 | KinChiu YuanZhou Sze‐ChunYeung Carmen Ka‐MingLok Owen O‐CheungChan Raymond Chuen‐ChungChang Kwok‐FaiSo Jin‐FuChiu | 2010 | J Cell Biochem2010，，2： | 1 |
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