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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Revisiting the predictive validity of emotional intelligence: self-report versus ability-based measures显示文摘 | Raymond M O Connor J Ian S L | 2003 | Personality and In- dividual Differences2003，35，8： | 1 |
| 3 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 4 | Draft1 , a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation 显示文摘 | Raymond C S Murphy M W O'Sullivan M G etal | 2000 | Genes Dev2000，14，20： | 1 |
| 5 | Tinkering with the C- Function: A Molecular Frmne for the Selection of Double Flowers in Cultivated Roses 显示文摘 | Dubois A Raymond O Maene M e! al | 2010 | Plos One2010，5，2： | 1 |
| 6 | Tinkering with the C function: a molecular frame for the selection of double flowers in cultivated roses显示文摘 | Dubois A Raymond O Maene M | 2010 | PLoS One2010，5，2： | 1 |
| 7 | Tinkering with the C-function:a molecular frame for the selection of double flowers in cultivated roses显示文摘 | DUBOIS A RAYMOND O MAENE M | 2010 | Plos One2010，5，2： | 1 |
| 8 | Major ecological transitions in wild sunflowers facilitated by hybridization显示文摘 | RIESEBERG L H RAYMOND O ROSENTHAL D M | | 0，，： | 1 |
| 9 | The origin of ecological divergence in Helianthus paradoxus (Asteraceae):selection on transgressive characters in a novel hybrid habitat显示文摘 | LEXER C WELCH M E RAYMOND O | | 0，，09： | 1 |
| 10 | ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article显示文摘 | Raymond J Gibbons Jonathan Abrams Kanu Chatterjee Jennifer Daley Prakash C Deedwania John S Douglas T.Bruce Ferguson Stephan D Fihn Theodore D Fraker Julius M Gardin Robert A O’Rourke Richard C Pasternak Sankey V Williams Raymond J Gibbons Joseph S Alpert | 2003 | Journal of the American College of Cardiology2003，，1： | 1 |
| 11 | Major ecological transitions in wild sunflowers facilitated by hybridization显示文摘 | RIESEBERG L H RAYMOND O ROSENTHAL D M | | 0，，： | 1 |
| 12 | The ori- gin of ecological divergence in Helianthus paradoxus (As- teraceae) : Selection on transgressive characters in a novel hybrid habitat 显示文摘 | LEXER C WELCH M E RAYMOND O | 2005 | Evolution2005，57，9： | 1 |
| 13 | Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation显示文摘 | Raymond C S Murphy M W O\'Sullivan M G | 2000 | Genes & Development2000，14，20： | 1 |
| 14 | The promise of comparative genomics in mammals 显示文摘 | O'Brien S J Menotti - Raymond M and Murphy W J | 1999 | Science1999，，： | 1 |
| 15 | Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience显示文摘Hepatocellular carcinoma(HCC) is the most rapidly increasing type of cancer in the United States. HCC is a highly malignant cancer, accounting for at least 14000 deaths in the United States annually, and it ranks third as a cause of cancer mortality in men. One major difficulty is that most patients with HCC are diagnosed when the disease is already at an advanced stage, and the cancer cannot be surgically removed. Furthermore, because almost all patients have cirrhosis, neither chemotherapy nor major resections are well tolerated. Clearly there is need of a multidisciplinary approach for the management of HCC. For example, there is a need for better understanding of the fundamental etiologic mechanisms that are involved in hepatocarcinogenesis, which could lead to the development of successful preventive and therapeutic modalities. It is also essential to define the cellular and molecular bases for malignant transformation of hepatocytes. Such knowledge would:(1) greatly facilitate the identification of patients at risk;(2) prompt efforts to decrease risk factors; and(3) improve surveillance and early diagnosis through diagnostic imaging modalities. Possible benefits extend also to the clinical management of this disease. Because there are many factors involved in pathogenesis of HCC,this paper reviews a multidisciplinary perspective of recent advances in basic and clinical understanding of HCC that include: molecular hepatocarcinogenesis, noninvasive diagnostics modalities, diagnostic pathology, surgical modality, transplantation, local therapy and oncological/target therapeutics. | Matthew M Yeh Raymond S Yeung Smith Apisarnthanarax Renuka Bhattacharya Carlos Cuevas William P Harris Tony Lim Kiat Hon Siddharth A Padia James O Park Kevin M Riggle Sayed S Daoud | 2015 | World Journal of Hepatology2015，7，11： | 1 |
| 16 | Dmrtl, a gene retated to worm and fly sexual regulators, is required for mammalian testis differentiation 显示文摘 | Raymond C S Murphy M W O'Sullivan M G | 2000 | Genes Dev2000，14，20： | 1 |
| 17 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 18 | 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction显示文摘 | Thomas J Ryan Elliott M Antman Neil H Brooks Robert M Califf L.David Hillis Loren F Hiratzka Elliot Rapaport Barbara Riegel Richard O Russell Earl E Smith W.Douglas Weaver Raymond J Gibbons Joseph S Alpert Kim A Eagle Timothy J Gardner Arthur Garson Gabri | 1999 | Journal of the American College of Cardiology1999，，3： | 1 |
| 19 | Tinkering with the C- function: a molecular frame for the selection of double flowers in cultivated roses显示文摘 | Dubois A Raymond O Maene M | 2010 | Pios One2010，5，2： | 1 |
| 20 | Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials显示文摘 | Michelle L O’Donoghue Eugene Braunwald Elliott M Antman Sabina A Murphy Eric R Bates Yoseph Rozenman Alan D Michelson Raymond W Hautvast Peter N Ver Lee Sandra L Close Lei Shen Jessica L Mega Marc S Sabatine Stephen D Wiviott | 2009 | The Lancet2009，，9694： | 1 |
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