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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis显示文摘Chronic pancreatitis is known to be a heterogeneous disease with varied etiologies.Tropical calcific pancreatitis(TCP) is a severe form of chronic pancreatitis unique to developing countries.With growing evidence of genetic factors contributing to the pathogenesis of TCP,this review is aimed at compiling the available information in this field.We also propose a two hit model to explain the sequence of events in the pathogenesis of TCP. | Swapna Mahurkar D Nageshwar Reddy G Venkat Rao Giriraj Ratan Chandak | 2009 | World Journal of Gastroenterology2009，15，3： | 4 |
| 3 | Comprehensive screening for reg1α gene rules out association with tropical calcific pancreatitis显示文摘AIM: To investigate the allelic and haplotypic association of reg1α gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1α polymorphisms. METHODS: We analyzed the polymorphisms in the reg1α gene by sequencing the gene including its promoter region in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathogenesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes. RESULTS: We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1α. None of the 5' UTR variants altered any known transcription factor binding sites, neither did any show a statistically significant association with TCP. No association with any reg1α variants was observed on dichotomization of patients based on their N34S SPINK1 or L26V CTSB status. CONCLUSION: Polymorphisms in reg1α gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis. | Swapna Mahurkar Seema Bhaskar D Nageshwar Reddy G Venkat Rao Giriraj Ratan Chandak | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 4 | Immnopotentiation of bovine respiratory disease virus vaccines by interleukin-l and interleukin-2显示文摘 | Reddy D N Reddy P G Xue W | 1993 | Vet Immunol Immopathol1993，37，： | 2 |
| 5 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 6 | Transient hypersensitivity to soybean meal in the early-weaned pig显示文摘 | Nelssen J L Reddy P G | 1990 | J Anim Sci1990，68，6： | 1 |
| 7 | Transient hypersensitivity to soybean meal in the early-weaned pig显示文摘 | Li D F Nelssen J L Reddy P G | 1990 | Animal Science1990，68，： | 1 |
| 8 | Field crop responsesto ultraviolet-B radiation显示文摘 | Kakani V G Reddy K R Zhao D | 2003 | Agri For Meteor2003，120，： | 1 |
| 9 | Soy protein concentrate and heated soy flours as protein sources in milk replacer for preruminant calves显示文摘 | Dawson D P Morrill J L Reddy P G | 1988 | J Dairy Sci1988，71，： | 1 |
| 10 | Tagging: on the use of passive integrated transponder(PIT) tags for the identification of fish 显示文摘 | Mahapatra K D G erde B Reddy P V G K | 2001 | Aquacul Res2001，32，： | 1 |
| 11 | Genetic characterization of the silkworm Bombyx mori by simple sequence repeat (SSR)-anchored PCR 显示文摘 | Reddy K D Nagaraju J Abraham E G | 1999 | Heredity1999，83，： | 1 |
| 12 | Transient hypersensitivity to soybean meal in the early weaned pig 显示文摘 | Li D F Nelssen J L Reddy P G | 1990 | Journal of Animal Science1990，68，： | 1 |
| 13 | Recycling of a- luminum metal matrix composite using ionic liquids: Effect of process variables on current efficiency and de- posit characteristics显示文摘 | Kamavaram V Mantha D Reddy R G | 2005 | Electrochimica Acta2005，50，1617： | 1 |
| 14 | Electrochemical production of Ti- A1 alloys using TiC14-A1C13-1 -butyl-3-methyl imidazolium chloride (BmimC1) electrolytes 显示文摘 | Pradhan D Reddy R G | 2009 | Electrochimica Acta2009，54，： | 1 |
| 15 | High-energy intense ultraviolet light maybe an approch to treating groundwater contaminated with organics显示文摘 | REDDY D G | 1991 | Environ Sci Technol1991，25，3： | 1 |
| 16 | Transient hypersensitivity to soybean meal in the early-weaned pig显示文摘 | Li D F Nelssen J L Reddy P G | 1990 | J Anim Sci1990，68，： | 1 |
| 17 | Perivascular gene transfer of NADPH oxidase inhibitor suppresses angioplasty-induced neointimal proliferation of rat carotid artery显示文摘 | Dourron H M Jacobson G M Park J L Liu J Reddy D J Scheel M L | 2005 | Am J Physiol Heart Circ Physiol2005，288，： | 1 |
| 18 | A facile synthesis of 2,3-disubstituted-6-arylpyridines from enaminones using montmorillonite K10 as solid acid support显示文摘 | REDDY G J LATTA D THIRUPATHAIAH C | 2005 | Tetrahedron Lett2005，46，： | 1 |
| 19 | Measuring suitability ofsoybean products for early-weaned pigs with immunological criteria显示文摘 | Li D F Nelssen J L Reddy P G | 1991 | Journal of Animal Science1991，69，： | 1 |
| 20 | Recovery of copper from cop- per blast furnace slag 显示文摘 | Reddy R G Prabhu V L Mantha D | 2006 | Minerals & Metallurgical Processing2006，23，2： | 1 |
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