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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Degradation of chitosan and starch by 360kHz ultrasound显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 4 | Degradation of chitosan and starch by 360 kHz ultrasound显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 5 | Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas, Identification of novel molecular biomarkers for early diagnosis and therapy显示文摘 | Eliana B Renata AT Stefano C | 2006 | Gynecol Oncol2006，103，： | 1 |
| 6 | Degradatinon of chitosan and starch by 360 kHz ultrasound 显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 7 | Degradation of chitosan and starch by 360kHz ultrasound显示文摘 | RENATA C B BOZENA R SALAH L | 2005 | Carbohydrate Polymers2005，60，： | 1 |
| 8 | Determination of degree of deacetylation of chitosan-comparision of methods显示文摘 | RENATA C B DIANA J BOZENA R | 2012 | Progress on Chemistry and Application of Chitin and Its Derivatives2012，17，： | 1 |
| 9 | Degradation of chitosan and starch by 360 kHz ultrasound 显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 10 | Degradation of chitosan and starch by 360 kHz ultrasound显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 11 | A data based mechanistic approach to nonlinear flood routing and adaptive flood level forecasting显示文摘 | RENATA J R PETER C Y KEITH J B | 2008 | Advances in Water Resources2008，31，8： | 1 |
| 12 | Degradation of chitosan and starch by 360 kHz ultrasound显示文摘 | Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 13 | Degradation of chitosan and starch by 360-kHz ultrasound显示文摘 | RENATA C B BOZENA R SALAH L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 14 | Analytical derivatization-a tool for determination of orotic acid 显示文摘 | Renata H Petr B Lubomir C | 2004 | J Chromatogr B2004，799，： | 1 |
| 15 | Degradation of chitosan and starch by 360 kHz ultrasound显示文摘 | Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 16 | Degradation of chitosan and starch by 360-kHz ultrasound 显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 17 | Effects of high pressure on functional properties of soy protein显示文摘 | Renata T Whye P T Alan E B Richard A F Marcolo C | 2007 | Food Chemistry2007，104，1： | 1 |
| 18 | Optimisation of solid state fermentation of potato peel for the production of cellulolytic enzymes显示文摘 | Tamires C S Devson P P G Renata C F B | | 0，，133： | 1 |
| 19 | Obesity-associated ac- tivation of angiotensin and endothelin in the cardiovascular system显示文摘 | Matthias B Renata C Jana O | 2003 | Int J Biochem Cell Biol2003，35，： | 1 |
| 20 | Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes显示文摘 | Renata C Iolanda DA Patrizia B | 2007 | Mol Pharmacol2007，71，5： | 1 |
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