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| 1 | Climatic influences on cardiovascular diseases显示文摘Classical risk factors only partially account for variations in cardiovascular disease incidence;therefore,also other so far unknown features,among which meteorological factors,may influence heart diseases(mainly coronary heart diseases,but also heart failure,arrhythmias,aortic dissection and stroke)rates.The most studied phenomenon is ambient temperature.The relation between mortality,as well as cardiovascular diseases incidence,and temperature appears graphically as a'U'shape.Exposure to cold,heat and heat waves is associated with an increased risk of acute coronary syndromes.Other climatic variables,such as humidity,atmospheric pressure,sunlight hours,wind strength and direction and rain/snow precipitations have been hypothesized as related to fatal and nonfatal cardiovascular diseases incidence.Main limitation of these studies is the unavailability of data on individual exposure to weather parameters.Effects of weather may vary depending on other factors,such as population disease profile and age structure.Climatic stress may increase direct and indirect risks to human health via different,complex pathophysiological pathways and exogenous and endogenous mechanisms.These data have attracted growing interest because of the recent earth’s climate change,with consequent increasing ambient temperatures and climatic fluctuations.This review evaluates the evidence base for cardiac health consequences of climate conditions,and it also explores potential further implications. | Maurizio Giuseppe Abrignani Alberto Lombardo Annabella Braschi NicolòRenda Vincenzo Abrignani | 2022 | World Journal of Cardiology2022，14，3： | 5 |
| 2 | When sepsis affects the heart: A case report and literature review显示文摘A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient. | Giuseppe Clemente Antonino Tuttolomondo Daniela Colomba Rosaria Pecoraro Chiara Renda Vittoriano Della Corte Carlo Maida Irene Simonetta Antonio Pinto | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 3 | Awake Systolic Blood Pressure Variability Correlates With Target-Organ Damage in Hypertensive Subjects显示文摘 | Alfonso Tatasciore Giulia Renda Marco Zimarino Manola Soccio Grzegorz Bilo Gianfranco Parati Giuseppe Schillaci Raffaele De Caterina | 2007 | Hypertension2007，，2： | 3 |
| 4 | A non-metabolic function of hexokinase 2 in small cell lung cancer:promotes cancer cell stemness by increasing USP11-mediated CD133 stability显示文摘Background:Maintenance of cancer stem-like cell(CSC)stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self-renewal and tumor progression.As a key glycolytic enzyme,hexokinase 2(HK2)plays an instrumental role in aerobic glycolysis and tumor progression.However,whether HK2 directly contribute to CSC stemness maintenance in small cell lung cancer(SCLC)is largely unclear.In this study,we aimed to investgate whether HK2 independent of its glycolytic activity is directly involved in stemness maintenance of CSC in SCLC.Methods:Immunoblotting analyses were conducted to determine the expression of HK2 in SCLC CSCs and their differentiated counterparts.CSC-like properties and tumorigenesis of SCLC cells with or without HK2 depletion or overexpression were examined by sphere formation assay and xenograft mouse model.Immunoprecipitation and mass spectrometry analyses were performed to identify the binding proteins of CD133.The expression levels of CD133-associated and CSC-relevant proteins were evaluated by immunoblotting,immunoprecipitation,immunofluorescence,and immunohistochemistry assay.RNA expression levels of Nanog,POU5F1,Lin28,HK2,Prominin-1 were analyzed through quantitative reverse transcription PCR.Polyubiquitination of CD133 was examined by in vitro or in vivo ubiquitination assay.CD133+cells were sorted by flow cytometry using an anti-CD133 antibody.Results:We demonstrated that HK2 expression was much higher in CSCs of SCLC than in their differentiated counterparts.HK2 depletion inhibited CSC stemness and promoted CSC differentiation.Mechanistically,nonmitochondrial HK2 directly interacted with CD133 and enhanced CD133 expression without affecting CD133 mRNA levels.The interaction of HK2 and CD133 promoted the binding of the deubiquitinase ubiquitin-specific protease 11(USP11)to CD133,thereby inhibiting CD133 polyubiquitylation and degradation.HK2-mediated upregulation of CD133 expression enhanced the expression of cell renewal regulators,SCLC cell stemness,and tumor growth in mice.In addition,HK2 expression was positively correlated with CD133 expression in human SCLC specimens,and their expression levels were associated with poor prognosis of SCLC patients.Conclusions:These results revealed a critical non-metabolic function of HK2 in promotion of cancer cell stemness.Our findings provided new insights into the multifaceted roles of HK2 in tumor development. | Juhong Wang Fei Shao Yannan Yang Wei Wang Xueying Yang Renda Li Hong Cheng Sijin Sun Xiaoli Feng Yibo Gao Jie He Zhimin Lu | 2022 | Cancer Communications2022，42，10： | 2 |
| 5 | Influence of Screw Speeds of the Mixer at Low Temperature on Characteristics of Moz zarella Cheese显示文摘 | RENDA A BARBANO D M YUN J J | 1997 | Journal of Dairy Science1997，80，9： | 1 |
| 6 | Awake systolic blood pressure variability correlates with target organ damage in hypertensive subject s显示文摘 | Tat asciore A Renda G Zim arin o M | 2007 | Hypertension2007，50，2： | 1 |
| 7 | Applications of problem-based learning in the basic medical curriculum显示文摘 | Rendas AB Pinto PR Morais Mda G | 2002 | Acta Med Port2002，8，78： | 1 |
| 8 | Facilitated PCI: rationale, current evidence, open questions, and future directions 显示文摘 | Zimarino M Sacchetta D Renda G | 2008 | J Cardiovasc Pharmacol2008，51，： | 1 |
| 9 | Awake systolic blood pressure variability correlates with target-organ damage in hyperten- sive subjects 显示文摘 | Tatasciore A Renda G Zimarino M | 2007 | Hypertension2007，50，2： | 1 |
| 10 | Awake systolic blood pressure variability correlates with target-organ damage in hyper- tensive subjects显示文摘 | Tatasciore A Renda G Zimarino M | 2007 | Hypertension2007，50，2： | 1 |
| 11 | Principles and advantages of robotics in urologic surgery 显示文摘 | Renda A Vallancien G | 2003 | Curr Urol Rep2003，4，2： | 1 |
| 12 | Awake systolic blood pressure variability correlates with target-organ damage in hyper- tensive subjects显示文摘 | Tatasciore A Renda G Zimarino M | 2007 | Hypertension2007，50，2： | 1 |
| 13 | Toward meaningful learning in undergraduate medical education using concept maps in a PBL pathophysiology course显示文摘 | Rendas AB Fonseca M Pinto PR | 2006 | Adv Physiol Educ2006，30，1： | 1 |
| 14 | Awake systolic blood pressure variability correlates with target-organ damage in hypertensive subjects 显示文摘 | Tatasciore A Renda G Zimarino M | 2007 | Hypertension2007，50，2： | 1 |
| 15 | On the use of non-coherent fault trees in safety and security studies 显示文摘 | Contini S Cojazzi G G M Renda G | 2008 | Reliability Engineering and System Safety2008，93，： | 1 |
| 16 | Awake blood pressure variability, inflammatory markers and target organ damage in newly diagnosed hypertension 显示文摘 | Tatasciore A Zimarino M Renda G | 2008 | Hypertens Res2008，31，12： | 1 |
| 17 | Awake systolic blood pres- sure variability correlates with target-organ damage in hypertensive subjects 显示文摘 | Tatasciore A Renda G Zimarlno M | 2007 | Hypertension2007，50，2： | 1 |
| 18 | Increased activation of p38 MAPK in COPD显示文摘 | Renda T Baraldo S Pelaia G | 2008 | Eur Respir J2008，31，： | 1 |
| 19 | Dynamic interaction analysis of vehicle-bridge system using transfer matrix method显示文摘 | XIANG Tianyu ZHAO Renda | 2005 | Structural Engineering and Mechanics2005，20，1： | 1 |
| 20 | Awake systolic blood pressure variability correlates with target-organ damage in hypertensive subjects 显示文摘 | Tatasciore A Renda G Zimarino M | 2007 | Hypertension2007，50，2： | 1 |
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