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| 1 | Spectrum of anemia associated with chronic liver disease显示文摘Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. Severe hepatocellular disease predisposes to hemorrhage because of impaired blood coagulation caused by deficiency of blood coagulation factors synthesized by hepatocytes, and/or thrombocytopenia. Aplastic anemia, which is characterized by pancytopenia and hypocellular bone marrow, may follow the development of hepatitis. Its presentation includes progressive anemia and hemorrhagic manifestations. Hematological complications of combination therapy for chronic viral hepatitis include clinically signif icant anemia, secondary to treatment with ribavirin and/or interferon. Ribavirininduced hemolysis can be reversed by reducing the dose of the drug or discontinuing it altogether. Interferons may contribute to anemia by inducing bone marrow suppression. Alcohol ingestion is implicated in the pathogenesis of chronic liver disease and may contribute to associated anemia. In patients with chronic liver disease, anemia may be exacerbated by defi ciency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption. | Rosario Gonzalez-Casas E Anthony Jones Ricardo Moreno-Otero | 2009 | World Journal of Gastroenterology2009，15，37： | 13 |
| 2 | Liver disease and erythropoietic protoporphyria:A concise review显示文摘The porphyries are a group of metabolic disorders characterized by deficiencies in the activity of enzymes involved in the biosynthesis of heme.In erythropoietic protoporphyria(EPP),in the majority of cases an autosomal dominant disease,there is a mutation of the gene that encodes ferrochelatase(FECH).FECH deficiency is associated with increased concentrations of protoporphyrin in erythrocytes,plasma,skin and liver.The prevalence of this inherited disorder oscillates between 1:75 000 and 1:200 000.Clinical manifestations of EPP appear in early infancy upon first exposure to the sun.Nevertheless,approximately 5%-20% of patients with EPP develop liver manifestations.Retention of protoporphyrin in the liver is associated with cholestatic phenomena and oxidative stress that predisposes to hepatobiliary disease of varying degrees of severity,such as cholelithiasis,mild parenchymal liver disease,progressive hepatocellular disease with end-stage liver disease and acute liver failure.Liver damage is the major risk in EPP patients,so surveillance and frequent clinical and biochemical liver follow-up is mandatory.The diagnostic approach consists in detecting increased levels of protoporphyrin,decreased activity of FECH and genetic analysis of the FECH gene.A variety of nonsurgical therapeutic approaches have been adopted for the management of EPP associated with liver disease,but none of these has been shown to be unequivocally efficacious.Nevertheless,some may have a place in preparing patients for liver transplantation.Liver transplantation does not correct the constitutional deficiency of FECH.Consequently,there is a risk of recurrence of liver disease after liver transplantation as a result of continuing overproduction of protoporphyrin.Some authors recommend that bone marrow transplantation should be considered in liver allograft recipients to prevent recurrence of hepatic disease. | María José Casanova-González María Trapero-Marugán E Anthony Jones Ricardo Moreno-Otero | 2010 | World Journal of Gastroenterology2010，16，36： | 7 |
| 3 | Resistance and susceptibility of alfalfa (Medicago sativa L.) cultivars to the aphid Therioaphis maculata (Homoptera: Aphididae): insect biology and cultivar evaluation显示文摘蚜虫 Therioaphis maculata 的抽象生物学在苜蓿(Medicago sativa L.) 上被学习,包括四抵抗(Mesa-Sirsa, CUF101,贝克和 Lahontan ) 并且二易受影响(弧和 Caliverde ) 苜蓿栽培变种,并且大多数之一收割了巴西栽培变种, Crioula。在控制条件下面,抗生现象(即,减少的长寿,肥沃和蚜虫的增加的死亡) 主要在抵抗苜蓿栽培变种上被观察,除了在 Lahontan 上。Crioula 似乎对蚜虫容忍。现在的数据支持栽培变种的地理限制用法,并且我们作为抗生现象的来源建议贝克和 Mesa-Sirsa,并且提供热带 T 的生物信息。苜蓿上的 maculata 遗传因子型。 | ALEXANDRE DE ALMEIDA E SILVA ELENICE MOURO VARANDA JOSE RICARDO BAROSELA | 2006 | Insect Science2006，13，1： | 5 |
| 4 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 5 | Response surface methodology (RSM) as a tool for optimization in ana- lytical chemistry显示文摘 | MARCOS A B RICARDO E S ELIANE P 0 | 2008 | Talanta2008，76，5： | 1 |
| 6 | Influence of carbohydrates on the stability and structure of a hyperglycosylated human interferon alpha mutein显示文摘 | Natalia C Marina E Ricardo K | 2010 | Biochimie2010，92，： | 1 |
| 7 | Evaluation of Supply Chain Structures through Modularization and Postponement显示文摘 | Ricardo E Bardia K | | 0，，03： | 1 |
| 8 | The diffusion of technological knowledge through interlaced networks显示文摘 | Leonardo Costa Ribeiro Ricardo Machado Ruiz Eduardo da Motta e Albuquerque Américo T. Bernardes | 2010 | Computer Physics Communications2010，，9： | 1 |
| 9 | Adrenocotical carcinoma: surgical progress or status Quo显示文摘 | Michael L Ricardo L Lori E | 2001 | Arch Surg2001，5，： | 1 |
| 10 | Effect of copper on the photochemical efficiency,growth,and chlorophyll a biomass of natural phytoplankton assemblages Environmental显示文摘 | PATRICIA P R PATRICIA E V RICARDO B | 2006 | Toxicology and Chemistry2006，25，1： | 1 |
| 11 | Response surface methodology ( RSM ) as a tool for optimization in analytical chemistry 显示文摘 | Marcos A B Ricardo E S Eliane P O | 2008 | Talanta2008，，76： | 1 |
| 12 | Optimal surgical treatment for moyamoya disease in adults:direct versus indirect bypass 显示文摘 | Robert M Ricardo J Sander E | 2009 | Neurosurgical Focus2009，26，4： | 1 |
| 13 | Surface rough- ness and fatigue performance of commercially pure titanium and Ti-- 6AI-- 4V alloy after different polishing protocols 显示文摘 | Aderico S Guilherme E Ricardo A | 2005 | J Prosthet Dent2005，93，4： | 1 |
| 14 | Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve mollusks显示文摘 | Laurence M E Ricardo M L Ricardo A | 2004 | Molecular and Cellular Probes2004，18，： | 1 |
| 15 | Biochemical control of sulfide production in waste water collection systems 显示文摘 | RICARDO B J HAMDY H E | 1992 | National Conference on Environmental Engineering1992，2，： | 1 |
| 16 | Endothelial dysfunction:a comprehensive appraisal显示文摘 | Ricardo J E Roberto A N Qad F A | 2004 | Gen Intern Med2004，19，7： | 1 |
| 17 | Isolation of three thioredoxion from spinach lesves 显示文摘 | Ricardo A Wolosiuk Nancy A Crawford Boibon E | 1979 | J Biol Chem1979，，254： | 1 |
| 18 | Allocation of warehouse inventory with electronic data interchange and fixed order intervals显示文摘 | Ricardo E Bardia K | 1997 | European Journal of Operational Research1997，103，1： | 1 |
| 19 | Genetic structure of red sea bream(Pagrus major)population off Japan and the Southwest Pacific,using microsatellite DNA Markers显示文摘 | Ricardo P E Taniguchi N | 1999 | Fisheries Science1999，65，1： | 1 |
| 20 | Polyacrylic acid (poly-A) as a chelant and dispersant 显示文摘 | Debasish K Gekorge A B Ricardo E B | 1999 | Journal of Applied Polymer Science1999，73，7： | 1 |
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