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| 1 | Role of antispasmodics in the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a long-lasting,relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits.Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis,both of which require effective treatment.Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission.Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades.Alverine citrate,a spasmolytic,decreases the sensitivity of smooth muscle contractile proteins to calcium,and it is a selective 5-HT1A receptor antagonist.Alverine,in combination with simethicone,has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial.Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis.Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control;nevertheless,in recent placebo-controlled studies,mebeverine did not exhibit superiority over placebo.Otilonium bromide is poorly absorbed from the GI tract,where it acts locally as an L-type calcium channel blocker,an antimuscarinic and a tachykinin NK2receptor antagonist.Otilonium has effectively reduced pain and improved defecation alterations in placebocontrolled trials in IBS patients.Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract.Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients.Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial.Antispasmodics have excellent safety profiles.T-type calcium channel blockers can abolish visceral hypersensitivity in animal models,which makes them potential candidates for the development of novel therapeutic agents in the treatment of IBS. | Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann | 2014 | World Journal of Gastroenterology2014，20，20： | 15 |
| 2 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 3 | Four decades of continuing innovation with fluorouracil:current and future approaches to fluorouracil chemoradiation therapy显示文摘 | RICH T A SHEPARD R C MOSLEY S T | 2004 | J Clin Oncol2004，22，11： | 1 |
| 4 | Think tanks in the US media显示文摘 | Rich A Weaver R K | 2000 | The Harvard International Journal of Press/Politics2000，5，4： | 1 |
| 5 | Kinetics of Nitrogen-15-labeled ammonium ion assimilation in Zea mays 显示文摘 | Magalhaes J R Rich P J Rhodes D | 1990 | Plant Physiol1990，94，： | 1 |
| 6 | Making a tumour's bed: glioblasto- ma stem ceils and the vascular niche 显示文摘 | Gilbertson R J Rich JN | 2007 | Nat Rev Cancer2007，7，10： | 1 |
| 7 | Linking Job Demands and Resources to Employee Engagement and Burnout: A Theoretical Extension and Meta-Analytic Test 显示文摘 | Crawford E R LePine J A Louis Rich B | 2010 | Journal of Applied Psychology2010，95，5： | 1 |
| 8 | Survey of the year 2007 commercial optical literature显示文摘 | RICH R L MYSZKA D G | | 0，，： | 1 |
| 9 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
| 10 | sur face r ough ness and EDS ch ar acter ization of aY- TZP dentalcer amic tr eated w ith th e Co Jetl TM Sand 显示文摘 | Mar ia Catcani Lor ent Susar lne S Sch er r er Jacque S Rich ar d | 2010 | Dental Mater ials2010，26，11： | 1 |
| 11 | Linking top management team age heterogeneity to firm performance: juxtaposing two mid-range theories 显示文摘 | Rich O Shelor R | 2002 | The International Journal of Human Resource Management2002，，6： | 1 |
| 12 | A Constrained, Global- ized, and Bounded Nelder-Mead Method for Engineering Optimization 显示文摘 | Luersen M A R Le Riche | 2004 | Structural and Multidisciplinaxy Opti- mization2004，27，12： | 1 |
| 13 | Efinaconazole 10% solution in the treatment of toenail onychomycosis: two phase III multicenter, randomized, double-blind studies 显示文摘 | Elewski BE Rich P Pollak R | 2013 | JAm Acad Dermatol2013，68，4： | 1 |
| 14 | Use of repartitioning agents to improve performance and body composition of meat animals 显示文摘 | RICHS C A BAKER P K DALRYMPLE R H | 1984 | Reciprocal Meat Conf Pore1984，37，： | 1 |
| 15 | Optimization of laminate stacking sequence for buckling load maximization by genetic algorithm显示文摘 | Riche R Le Haftka R T | 1995 | AIAA Journal1995，31，5： | 1 |
| 16 | 显示文摘 | KVASNI CKA F SEV CIK R VOLD RICH M | 2006 | J Chromatogr: A2006，1113，： | 1 |
| 17 | Efficacy,safety and pharmacokinetics of palonosetron in patientsreceiving highly emetogenic cisplatin-based chemotherapy:a dose-ranging clinical study 显示文摘 | Elsenberg P Mackintosh F R Rich P | 2013 | Ann Oncol2013，15，2： | 1 |
| 18 | Using regional economic indexes to forecast tax bases:evidence from New York显示文摘 | RICH R BRAM J HAUGHWOUT A | 2005 | The Review of Economics and Statistics2005，87，4： | 1 |
| 19 | Role of pro-ton magnetic resonance spectroscopy in the diagnosis of gliomatosis cerebri:a unique pattern of normal choline but elevated Myoinositol metabolite levels显示文摘 | Imbesi SG Diet rich R | 2004 | J Comput Assist Tomogr2004，28，1： | 1 |
| 20 | The trace analysis of alkyl alkylphosphonic acids in urine using gas chromatography-ion trap negative ion tandem mass spectrometry显示文摘 | RICHES J MORTON I ROBERT W R BLACK R M | 2005 | J Chromatogr:B2005，816，12： | 1 |
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