|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode显示文摘AIM: To explore the effect of Echinococcus multilocularis (E. multilocularis) on the activation of mitogen-activated protein kinase (MAPK) signaling pathways and on liver cell proliferation. METHODS: Changes in the phosphorylation of MAPKs and proliferating cell nuclear antigen (PCNA) expression were measured in the liver of patients with alveolar echinococcosis (AE). MAPKs, MEK1/2 [MAPK/ extracellular signal-regulated protein kinase (ERK) kinase] and ribosomal S6 kinase (RSK) phosphorylation were detected in primary cultures of rat hepatocytes in contact in vitro with (1) E. multilocularis vesicle fluid (EmF), (2) E. multilocularis-conditioned medium (EmCM). RESULTS: In the liver of AE patients, ERK 1/2 and p38 MAPK were activated and PCNA expression was increased, especially in the vicinity of the metacestode. Upon exposure to EmF, p38, c-Jun N-terminal kinase (JNK) and ERK1/2 were also activated in hepatocytes in vitro, as well as MEK1/2 and RSK, in the absence of any toxic effect. Upon exposure to EmCM, only JNK was up-regulated. CONCLUSION: Previous studies have demonstrated an influence of the host on the MAPK cascade in E. multilocularis. Our data suggest that the reverse, i.e. parasite-derived signals efficiently acting on MAPK signaling pathways in host liver cells, is actually operating. | Ren-Yong Lin Jun-Hua Wang Xiao-Mei Lu Xiao-Tao Zhou Georges Mantion Hao Wen Dominique A Vuitton Lysiane Richert | 2009 | World Journal of Gastroenterology2009，15，17： | 15 |
| 2 | High temperature mechanical behavior of liquid phase sintered silicon carbide 显示文摘 | Keppeler M Richert H G BroadleyJ M | 1998 | Joumal of the European Ceramic Society1998，18，5： | 1 |
| 3 | Use of Dopamine Polymerisation to Produce Free-standing Membranes from(PLL-HA) Nexponentially Growing Multilayer Films显示文摘 | Bernsmann F Richert L Senger B | 2008 | Soft Matter2008，4，7： | 1 |
| 4 | Physical aging and heterogeneous dynamics 显示文摘 | Richert R | 2010 | Phys Rev Lett2010，104，85： | 1 |
| 5 | Understandings of environmental quality: ambiguities and values held by environmental professionals显示文摘 | Hull R B Richert D Seekamp E | 2003 | Environmental Management2003，3，： | 1 |
| 6 | Effect of large deformations on the microstructure of aluminium alloys显示文摘 | RICHERT M RICHERT J ZASADZINSKI J HAWRYLKIEWICZ S DLUGOPOLSKI J | 2003 | Materials Chemistry and Physics2003，81，23： | 1 |
| 7 | Effect of dietary vitamin E supplementation and feeding period on pork quality 显示文摘 | Guo Q Richert B T Burgess J R | 2006 | J Anim Sci2006，84，： | 1 |
| 8 | Work hardening and microstructure of A1Mg5 after severe plastic deformation by cyclic extrusion and compression 显示文摘 | RICHERT M STUWE H P ZEHETBAUER M J RICHERT J PIPPAN R MOTZ C SCHAFLER E | 2003 | Materials Science and Engineering A2003，355，： | 1 |
| 9 | A new method for unlimited deformation of metals and alloys显示文摘 | RICHERT J RICHERT M | 1986 | Aluminium (Germany)1986，62，8： | 1 |
| 10 | Effects of dietary vitamin E and fat supplementation on pork quality显示文摘 | GUO Q RICHERT B BURGESS J | 2006 | Journal of Animal Science2006，84，11： | 1 |
| 11 | Effect of dietary vitamin E supplementation and feeding period on pork quality显示文摘 | GUO Q RICHERT B BURGESS J | 2006 | Journal of Animal Science2006，84，11： | 1 |
| 12 | Optimal Linear Combina- tions of Triple Frequency Carrier Phase Data from Future Global Navigation Systems 显示文摘 | RICHERT T EI - SHEIMY N | 2007 | GPS Solution2007，，11： | 1 |
| 13 | Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment显示文摘 | Richert MM Phadke PA Matters G | 2005 | Breast Cancer Res2005，7，5： | 1 |
| 14 | Scabies: a common infection nevertheless often misdiagnosed 显示文摘 | Barthe L Dezfoulian B Richert B | 1996 | Rev Med Liege1996，51，8： | 1 |
| 15 | Effects of conjugated linoleic acid (CLA) on growth,carcass composition and pork quality of two genotypes of lean gilts显示文摘 | Eggert J M Carroll A L Richert B T | 1999 | J Anim Sci1999，77，： | 1 |
| 16 | An atlas of mouse mammary gland development显示文摘 | Richert M M Schwertfeger K L Ryder J W | 2000 | J Mammary Gland Biol Neoplasia2000，5，2： | 1 |
| 17 | Development of PCR primers specific for the amplification and direct sequencing of gyrB genes from microbacteria,order Actinomycetales显示文摘 | RICHERT K BRAMBILLA E STACKEBRANDT E | 2005 | Microbiol Methods2005，60，： | 1 |
| 18 | Effects of dietary levels of selenium-enriched yeast and sodium selenite as selenium sources fed to growing-finishing pigs on performance,tissue selenium,serum glutathione peroxidase activity,carcass characteristics,and loin quality显示文摘 | MAHAN D C CLINE T R RICHERT B | 1999 | Journal of Animal Science1999，77，： | 1 |
| 19 | Layer by layer buildup of polysaccharide films: physical chemistry and cellular adhesion aspects 显示文摘 | Richert L Lavalle P Payan E Shu XZ Prestwish GD Stohz J-F Schaaf P Voegel JC Picart C | 2004 | Langmuir2004，20，： | 1 |
| 20 | Requirement for IGF-I in epidermal growth factor-mediated cell cycle progression of mammary epithelial cells显示文摘 | Stu11 MA Richert MM Loladze AV | | 0，，05： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员