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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Regression of liver metastases of occult carcinoid tumor with slow release Lanreotide therapy显示文摘Few clinical studies have demonstrated an anti-proliferative activity of somatostatin (SST) analogs in carcinoids. We report the case of a woman with liver metastases of neuroendocrine tumor and no evidence of the primary tumor. The liver metastases were characterized by high proliferation indes, immunoreactiviy for somatostatin receptor (SSTR) -1,2,3 and 5and positive octreoscan. Urinary 5-hydrozyindolacetic acid, serum serotonin and chromogranin A were elevated. Slow release lanretoide (SR-LAN) therapy for 3 mo controlled clinical and biochemical signs of carcinoid tumor and caused a clear-cut reduction in the diameter of two liver metastases and disappearance of another lesion, with further reduction after 6 and 18 mo. We demonstrated a Clear-cut long-lasting antioccult carcinoid with high proliferation index and immunoreactivity for SSTR-1,2,3, and 5. Immunohistochemistry for SSTRs could be a suitable method for the selection of patients with metasatic carcinoid that may benefit from SST analog therapy. | Marta Bondanelli Maria Rosaria Ambrosio Maria Chiara Zatelli Luigi Cavazzini Laura Al Jandali Rifa'y Ettore C.degli Uberti | 2005 | World Journal of Gastroenterology2005，11，13： | 7 |
| 3 | Terminal cancer : Duration and prediction of survival time显示文摘 | Llobera J Esteva M Rifa J | 2000 | Eur J Cancer2000，36，16： | 1 |
| 4 | Differentiation of human bone marrow osteogenic stromal cells in vitro:induction of the osteoblast phenotype by dexamethasone显示文摘 | Cheng SL Yang JW Rifas L | 1994 | Endocrinology1994，134，： | 1 |
| 5 | Associations of physical activity and inactivity before and during pregnancy with glucose tolerance 显示文摘 | Oken E Ning Y Rifas - Shiman SL | 2006 | Obstet Gynecol2006，108，5： | 1 |
| 6 | Bone and Cytokines: Beyond IL-1, IL-6 and TNF-α显示文摘 | A. Rifas | 1999 | Calcified Tissue International1999，，1： | 1 |
| 7 | R-CHOP-14 in patients with diffuse large B-cell lymphoma younger than 70 years: a multicentre, prospective study显示文摘 | Rueda A Sabin P Rifa J | 2008 | Hematol Oncol2008，26，1： | 1 |
| 8 | T-cell cytokine induction of BMP-2 regulates hu- man mesenchymal stromal cell differentiation and mineraliza- tion显示文摘 | Rifas L | 2006 | J Cell Biochem2006，98，4： | 1 |
| 9 | Expression of metalloproteinases and issue inhibitors of metalloproteinases in human osteoblast-like cells:dif- ferentiation is associated with repression of metalloproteinase biosynthesis 显示文摘 | Rifas L Fausto A Scott M J | 1994 | Endocrinology1994，134，2： | 1 |
| 10 | Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts显示文摘 | Rifas L Arackal S Weitzmann N | 2001 | J Cell Bio2001，88，： | 1 |
| 11 | Differentiation of human bone marrow osteogcnic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone显示文摘 | Cheng SL Yang JW Rifas L | 1994 | Endocrinology1994，134，1： | 1 |
| 12 | Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteo- blast phenotype by dexamethasone显示文摘 | Cheng SL Yang JW Rifas L | 1994 | Endocrinology1994，134，1： | 1 |
| 13 | Pea- nut allergy prevalence among school age children in a US co hort not selected for any disease显示文摘 | Bunyavanich S Rifas Shiman S L Plat ts Mills T A | 2014 | J Allergy Clin Immunol2014，134，3： | 1 |
| 14 | T cell activation induces human osteoclast formation via receptor activator of nuclear factor kappaB ligand-dependent and independent mechanisms显示文摘 | Weitzmann MN Cenci S Rifas L | 2001 | J Bone Miner Res2001，16，： | 1 |
| 15 | A fast algorithm to compute irreducible and primitive polynomials in finite fields 显示文摘 | RIFA J BORRELL J | 1995 | Math Systems Theory1995，，28： | 1 |
| 16 | Changes in dietary intake from the first to the second trimester of pregnancy显示文摘 | Rifas Shiman SL Rich Edwards JW Willett WC | 2006 | Paediatric and Perinatal Epidemiology2006，20，1： | 1 |
| 17 | Maternal gestational diabetes,birth weight,and adolescent obesity显示文摘 | Gillman M W Rifas S S Berkey C S | 2003 | Pediatrics2003，111，3： | 1 |
| 18 | Blood pressure and inflammation in apparently healthy men 显示文摘 | Chae CU Lee RT Rifa N | 2001 | Hypertension2001，38，3： | 1 |
| 19 | Essential roles of CD8 CD122 + regulatory T cells in the maintenance of T cellhomeostasis显示文摘 | RIFA'I M KAWAMOTO Y NAKASHIMA I | 2004 | J Exp Med2004，200，5： | 1 |
| 20 | Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis 显示文摘 | Pacifici R Rifas L Teitelbaum S | 1987 | Proc Natl Acad Sci USA1987，84，： | 1 |
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