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| 1 | From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?显示文摘Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease. | Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira | 2022 | Neural Regeneration Research2022，17，5： | 2 |
| 2 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 3 | Characterization of polypyrrole silver nanocomposites prepared in the presence of different dopants显示文摘 | ENIKO P RITA P TAMAS F | 2005 | J Phys Chem B2005，109，17： | 1 |
| 4 | Cross-talk between neurons and astrocytes in response to bilirubin:adverse secondary impacts显示文摘 | Ana Sofia Falc?o Rui F M Silva Ana Rita Vaz | | 0，，： | 1 |
| 5 | Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures显示文摘 | Fabio F Daniela P Rita C | 2012 | J Androl2012，33，2： | 1 |
| 6 | Morphological and functional retinal impairment in Alzheimer's disease patients 显示文摘 | Vincenzo P Rita R Francesco F | 2001 | Clin Neurophysi2001，112，10： | 1 |
| 7 | Personality,basic emotions,and satisfaction:Primary emotions in the mountaineering experience显示文摘 | RITA F KURT M TODD A | | 0，，： | 1 |
| 8 | Enhanced motor cor- tex facilitation in patients with vascular cognitive impair- ment no dementia显示文摘 | Rita B Raffaele F Manuela P | 2011 | Neurosci Lett2011，503，3： | 1 |
| 9 | Cytochemical localization of calcium and X-ray microanalysis of Catharanthus roseus infected with phytoplasmas显示文摘 | RITA M MARIA A F | 2003 | Micron2003，34，： | 1 |
| 10 | Polyhydroxylated tri-terpenes from Eriobotrya japonica显示文摘 | Zhou Z L Rita A Vincenzo D F | 1990 | Planta Med1990，56，3： | 1 |
| 11 | Prediction of disulfide connectivity in proteins显示文摘 | Piero F Rita C | 2001 | Bioinformatics2001，17，8： | 1 |
| 12 | Agritourism:motivations behind farm/rarch business diversification,journal of travel research显示文摘 | NORMA POLOVITZ NICKERSON RITA J BLACK STEPHEN F MCCOOL | 2001 | Norma Polovitz Nickerson2001，，1： | 1 |
| 13 | Novel 3D scaffolds of chitosan-PLLA blends for tissue engineering applications:Preparation and characterization显示文摘 | Ana Rita C.Duarte Joao F Mano Rui L Reis | | 0，，： | 1 |
| 14 | Seroloyic evidence of an association between enteroviruses and the onset of Type I diabetes mellitus显示文摘 | Rita F Helfand Howard E Gary Jr | 1995 | Infect Dis1995，172，5： | 1 |
| 15 | Avoidance of system- ic anticoagulation during intermittent haemodialysis with heparin-grafted polyacrilonitrile membrane and ci- trate-enriched dialysate: a retrospective cohort study 显示文摘 | Karlien F Karl Rita J | 2014 | BMC Nephrology2014，15，3： | 1 |
| 16 | Once-daily tacrelimus extended release formulation:experience at 2 years pestconversion from a prograf -based regimen in stable liver transplant recipients显示文摘 | Sander F Rita A Munei K | 2007 | Transplantation2007，83，： | 1 |
| 17 | Noninvasive Ventilation Coupled With Nebulization During Asthma Crises:A Randomized Controlled Trial显示文摘 | Galindo-Filho V C Brand?o D C Rita de Cássia S F | 2013 | Respira Care2013，58，2： | 1 |
| 18 | Timing of Development of Measles-Specific Immunoglnb-ulin M and G after primary Measles Vaccination 显示文摘 | Rita F Helfand Senait Kebede Howard E Gary | 1996 | Clin Diagn Lab Immunol1996，6，2： | 1 |
| 19 | Comparison of oral pentazocine,oral diazepam and intramuscular pentazocine for paediatric premedication显示文摘 | RITA L SELENY F L GOODARZI M | 1983 | Can Anaesth Soc J1983，30，5： | 1 |
| 20 | Unsuspected tuberculosis in COPD and use of levofloxacin :Diagnostic challenges显示文摘 | Vitorino M D S Rosane Rodrigues M Letlcia Rita F | 2014 | Le Infezioni in Medicina Rivista Periodica Di Eziologia Epidemiologia Diagnostica Clinica E Terapia Delle Patologie Infettive2014，22，4： | 1 |
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