|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microscopic colitis:A large retrospective analysis from a health maintenance organization experience显示文摘AIM:To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis (MC) in Southern California and to determine the association of MC with inflammatory bowel disease (IBD) and colorectal cancer.METHODS: All patients diagnosed with MC by colonic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients' medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnicity, and medications were analyzed. An age-and sexmatched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis (LC), collagenous colitis (CC) and the control group.RESULTS: A total of 547 cases of MC were identif ied,376 patients with LC and 171 patients with CC. The female/male ratio was 3:1 in CC and 2.7:1 in LC patients. Celiac disease (P<0.001), irritable bowel syndrome (IBS) (P<0.001), and thyroid diseases (P<0.001) were found to have a higher occurrence in MC compared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group.CONCLUSION: This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Furthermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study. | Kevin T Kao Benito A Pedraza Amy C McClune David A Rios Yi-Qiong Mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas | 2009 | World Journal of Gastroenterology2009，15，25： | 5 |
| 2 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 3 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 4 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 5 | Transcriptional Regulatory Networks in Saccharomyces Cerevisiae显示文摘 | Lee T I Rinaldi N J Robert F | 2002 | Science2002，298，： | 1 |
| 6 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 7 | Comparisons andcontrasts of shale gas and tight gas developments, NorthAmerica experience and trends 显示文摘 | Robert L K William N K Daniel T G | 2012 | SPE 1608552012，，： | 1 |
| 8 | Transcriptional regulatory networks in Saccharomyces cerevisiae 显示文摘 | Lee T I Rinaldi N J Robert F | 2002 | Science2002，298，： | 1 |
| 9 | Effects of beta-blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy(from the Multicenter Automatic Defibrillator Implantation Trial-Ⅱ)显示文摘 | William N Robert T John KL | | 0，，05： | 1 |
| 10 | Transcriptional regulatory networks in Saccharomyces cerevisiae 显示文摘 | Lee T I Rinaldi N J Robert F | 2002 | Science2002，298，5594： | 1 |
| 11 | The interactions between trading volume and volatility:Evidence from the equity options markets显示文摘 | Park T H Lorne N S Robert B | 1999 | Applied Finance Economics1999，9，6： | 1 |
| 12 | Transcriptional regulatory networks in saccharomyces cerevisiae 显示文摘 | Lee T I Rinaldi N J Robert F | 2002 | Science2002，298，： | 1 |
| 13 | Special issue correspon- dence doubly resonant cymbal-type transducers 显示文摘 | JAMES F T ROBERT E N | 1997 | IEEE Trans Ultrason Ferro Elect Freq Contr1997，44，5： | 1 |
| 14 | The effect of sodium chloride and temperature on the rate and extent of growth of Clostridium botulinum type a in pasteurized pork slurry显示文摘 | Gibson A M Bratchell N Roberts T A | | 0，，： | 1 |
| 15 | Transcriptional regulatory net- works in saecharomyces cerevisia显示文摘 | Lee T I Rinaldi N J Robert F | 2002 | Science2002，298，5594： | 1 |
| 16 | Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy显示文摘 | Abdel Wahab N Weston B S Roberts T | 2002 | J Am Soc Nephrol2002，13，10： | 1 |
| 17 | Connective tissue growth factor and regulation of the mesangial cell cycle:role in cellular hypertrophy显示文摘 | Abdel-Wahab N Weston BS Roberts T | 2002 | J Am Soc Nephrol2002，13，10： | 1 |
| 18 | Testing and Analysis of Steel-Concrete-Steel Sandwich Beams 显示文摘 | ROBERTS T M EDWARDS D N NARAYANAN R | 1996 | Journal of Construction Steel Research1996，38，3： | 1 |
| 19 | Optimized ef? ciency and angular emission characteristics of white topemitting organic electroluminescent diodes显示文摘 | Michael T Robert N Mauro F el al | 2009 | Appl Phys Lett2009，94，08： | 1 |
| 20 | Predicting microbial growth : Growth responses of Salmonellae in a laboratory medium as affected by pH, sodium chloride, and storage temperature显示文摘 | Gibson A M Bratchell N Roberts T A | 1988 | Int J Food Microbiol1988，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员