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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | Peptides that non-covalently functionalize single-walled carbon nano-tubes to give controlled solubility characteristics显示文摘 | Witus LS Rocha JR Yuwono VM | | 0，，19： | 1 |
| 4 | Facial nerve in rhytidoplasty:anatomic study of its trajectory in the overlying skin and the most common sites of injury显示文摘 | FADUL R Jr Da ROCHA M A | 2003 | Ann Plast Surg2003，51，3： | 1 |
| 5 | Nutrition educa- tion tools used in phenylketonuria: clinician, parent and patient perspectives from three international surveys显示文摘 | Bernstein LE Helm JR Rocha JC | 2014 | J Hum Nutr Diet2014，27，2： | 1 |
| 6 | Hyperosmotic NaCl and severe hemorrhagic shock显示文摘 | VELASCO I T PONTIERI V ROCHAE SILVA M JR | 1980 | Am J Phsiol1980，239，5： | 1 |
| 7 | Lactate detection by MRS in mitochondrial encephalopathy: optimi- zation of technical parameters显示文摘 | Jos6 da Rocha A Ttllio Braga F Carlos Martins Maia A Jr | 2008 | J Neuroimaging2008，18，： | 1 |
| 8 | Straight and angulated abutments in platform switching:influence of loading on bone stress by three-dimensional finite element analysis显示文摘 | Martini AP Freitas AC Jr Rocha EP | | 0，，02： | 1 |
| 9 | Stability evaluation of an immobilized enzyme system of inulin hydrolysis 显示文摘 | R Catana M Eloy JR Rocha | 2007 | Food Chemistry2007，101，： | 1 |
| 10 | Finite element stress analysis of edentulous mandibles with different bone types supporting multiple-implant super-structures显示文摘 | de Almeida EO Rocha EP Freitas AC JR | 2010 | Int J Oral Maxil- lofac Implants2010，25，6： | 1 |
| 11 | Alternative technique of laparoscopic hepaticojejunostomy for advanced pancreatic head cancer显示文摘 | Maehado MA Rocha JR Herman P | 2000 | Surg Laparosc Endose Percutan Tech2000，10，： | 1 |
| 12 | Lactate detection by MRS in mitochondrial encephalopathy: optimization of technical parameters 显示文摘 | Jos e da Rocha A TO lio Braga F Carlos Martins Maia A Jr | 2008 | Neuroimaging2008，18，1： | 1 |
| 13 | MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in Nonenhancing Gliomas显示文摘 | Maia AC Jr Malheiros SM Da Rocha AJ | 2005 | AJNR2005，26，4： | 1 |
| 14 | Hyperosmotic NaCl and severe hemorrhagic shock 显示文摘 | Velasco IT Pontieri V Rocha e Silva M Jr | 1980 | Am J Physiol1980，239，5： | 1 |
| 15 | Antifibrotic effect of tamoxifen in a model of progressive renal disease 显示文摘 | DELLE H ROCHA JR CAVAGLIERI RC | 2012 | JAm Soc Nephrol2012，23，1： | 1 |
| 16 | Light and electron microscopy of classical Ehlers-Danlos syndrome显示文摘 | de Almeida HL Jr Bicca E Rocha NM | 2013 | Am J Dermatopathol2013，35，： | 1 |
| 17 | Hyperosmotic NaCI and severe hemorrhagic shock 显示文摘 | Velasco IT Pontieri V Rocha e Silva M Jr | 1980 | Am J Physiol1980，239，5： | 1 |
| 18 | Hyperosmotic NaC1 and severe hemorrhagic shock: role of the innervated lung显示文摘 | Lopes OU Pontieri V Rocha e Silva M Jr | 1981 | Am J Physiol1981，241，6： | 1 |
| 19 | True splenic cyst treated with videolaparoscopy:ease report and review of the literature显示文摘 | Sobrado CW Mackdisse F Da Rocha JR | 1998 | Rev Hosp Clin Fac Med Sao Paulo1998，53，5： | 1 |
| 20 | Interictal behavioral disturbances:a search for molecular substrates显示文摘 | Engel J Jr Rocha LL | 1992 | Epilepsy Res Suppl1992，9，： | 1 |
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