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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 3 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 4 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 5 | Reactions of keratinocytes to in vitro millimeter wave exposure 显示文摘 | Szabo I Rojavin M A Rogers T J | 2001 | Bioelectromagnetics2001，22，5： | 1 |
| 6 | Dissociation of cognitive and emotional empathy in Adults with Asperger syndrome: Using the Multifaceted Empathy Test (MET)显示文摘 | Dziobek I Rogers K Fleck S Bahnemann M Heekeren H Wolf O Convit A | 2008 | Journal of Autism and Developmental Disorders2008，38，： | 1 |
| 7 | Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization显示文摘 | Selinger C I Rogers T M Russell P A | 2013 | Mod Pathol2013，26，12： | 1 |
| 8 | Empathy and so-cial perspective taking in children with attention deficit/hyperactivity disorder 显示文摘 | Marton I Wiener J Rogers M | 2009 | J Abnorm Child Psychol2009，37，1： | 1 |
| 9 | Formation and cot, lapse of metastable particle packings and open structure in loess deposits显示文摘 | Assallay A M Rogers C D F Smatley I J | 1997 | Engeering Geology1997，48，12： | 1 |
| 10 | Formation and properties of a synthetic bone composite: Hydroxyapatite-collagen显示文摘 | Roger I M Maria K | 1995 | Journal of Biomedical Materials Research1995，29，： | 1 |
| 11 | Engineering properties of lo-ess in Libya 显示文摘 | Assallay A M Rogers C D F Smalley I J | 1996 | Journal of Arid Environments1996，32，4： | 1 |
| 12 | Engineering Properties of Loess in Libya 显示文摘 | ASSALLAY A M ROGERS C D F SMALLEY I J | 1996 | Journal of Arid Environments1996，32，4： | 1 |
| 13 | Fragipan forma- tion in loess soils: Development of the Bryant hydroconsolidation hypothesis显示文摘 | Assallay A M Jefferson I Rogers C D F | 1998 | Geoderma1998，83，12： | 1 |
| 14 | Sleep and metabolic control : waking to a problem显示文摘 | Trenell M I Marshall N S Rogers N L | 2007 | ClinExp Pharmacol Physiol2007，34，12： | 1 |
| 15 | Formation and Collapse of Metastable Particle Packings and Open Structures in Loess Deposits显示文摘 | A M Assallay C D F Rogers and I J Smalley | 1997 | Engineering Geology1997，48，： | 1 |
| 16 | A distinct lineage of influenza A virus from bats显示文摘 | Tong S Li Y Rivailler P Conrardy C Castillo D A Chen L M Recuenco S Ellison J A Davis C T York I A Turmelle A S Moran D Rogers S Shi M Tao Y Weil M R Tang K Rowe L A Sammons S Xu X Frace M Lindblade K A Cox N J Anderson L J Rupprecht C E Donis R O | 2012 | PANS2012，109，11： | 1 |
| 17 | Computer hexapod assisted orthopaedic surgery (CHAOS) in the correction of long bone fracture and deformity显示文摘 | Rogers M J McFadyen I Livingstone JA | 2007 | Orthop Trauma2007，5，： | 1 |
| 18 | Crystal structure of theMycobacterium tuberculosis dUTPase: insights into the catalytic mechanism 显示文摘 | Chan S Segelke B Lekin T Krupka H Cho US Kim MY So M Naranjo CM Rogers YC Park MS Waldo GS Pashkov I Cascio D Perry JL Sawaya MR | 2004 | J Mol Biol2004，341，2： | 1 |
| 19 | Reactions of keratinocytes to in vitro millimeter wave exposure 显示文摘 | SZABO I ROJAVIN M A ROGERS T J | 2001 | Bioeetromagnetie2001，22，： | 1 |
| 20 | Soft microfluidic assemblies of sen- sors,circuits, and radios for the skin显示文摘 | Xu S Zhang Y Jia L Mathewson K E Jang K I Kim J H Fu H Huang X Chava P Wang R Bhole S Wang L Na Y J Guan Y Flavin M Han Z Huang Y Rogers J A | 2014 | Science2014，344，6179： | 1 |
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