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| 1 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 2 | ESL/EFL instructors' classroom assessment practices: Purposes, methods, and procedures 显示文摘 | Cheng L Rogers T Hu H | 2004 | Language Testing2004，21，3： | 1 |
| 3 | Parameter control in evolutionary algorithms 显示文摘 | AGOSTON E E ROGER T H ZBIGHIE W M | 1999 | IEEE Transactions on Evolutionary Computation1999，3，2： | 1 |
| 4 | Immune responses to airborne fungi and non-invasive airway diseases 显示文摘 | Vacher G Niculita-Hirzel H Roger T | 2015 | Semin Immunopathol2015，37，2： | 1 |
| 5 | Electrostatic comb drive levitation and control method 显示文摘 | Tang W C Lira M G Roger T H | 1992 | Journal of Microelectromechanical Systems1992，1，4： | 1 |
| 6 | Project Partnering: A Medium for Private and Public Sector Collaboration 显示文摘 | T Roger Manley Wade H Shaw Robert C Manley | 2007 | Engineering Management Journal2007，19，20： | 1 |
| 7 | Job performance deficits due to depression 显示文摘 | Adler D A McLaughlin T J Rogers W H | 2006 | Am J Psychiatry2006，163，： | 1 |
| 8 | Gefarnate stimulates goblet cell repopulation following at experimental wound to the tarsal conjunctiva in rabbit显示文摘 | Katsuhiko N Hiroshi T Takashi H Masatsugu N Doan N Roger WB | 2000 | Cornea2000，19，6： | 1 |
| 9 | Slow coherency based network partitioning including load buses power systems显示文摘 | Yusof S B Rogers G J Alden R T H | 1993 | IEEE Transactions on Power Systems1993，8，3： | 1 |
| 10 | Survival and proliferative roles of erythropoietin beyond the erythroid lineage显示文摘 | Noguchi C T Wang L Rogers H M | 2008 | Expert Rev Mol Med2008，10，： | 1 |
| 11 | A multi-objeCtive combinatorial model of casualty processing in major incident response显示文摘 | Duncan T W Glenn I H Graham C Roger S C | 2013 | European Journal of Operational Research2013，230，： | 1 |
| 12 | Cloning of an Erwinia herbicola gene necessary for gluconie acid production and enhanced mineral phosphate solubilization in Escherichia coli IIB101: Nucleotide sequenee and propable involvement in biosynthesis of the coenzyme pyrroloquinoline quinine 显示文摘 | Liu S T Lee L Y Tai C Y Hung C H Chang Y S Wolfram J H Rogers R Goldstein A H | 1992 | Journal of Bacteriology1992，174，18： | 1 |
| 13 | Thermal Expansion of Ideal Poly- mer Crystals: application to Polyethylene显示文摘 | BARRON T H ROGERS K J | 2006 | Molecular Simulation2006，4，1： | 1 |
| 14 | Stretchable batteries with self-similar serpentine interconnects and integrated wireless re- charging systems 显示文摘 | Xu S Zhang Y H Cho J Lee J W Huang X Jia L Fan J A Su Y W Su J Zhang H Cheng H Lu B Yu C J Chuang C Kim T I Song T Shigeta K Kang S Dagdeviren C Petrov I Braun P V Huang Y Paik U Rogers J A | | Nature Communications0，4，： | 1 |
| 15 | Crystal structure of theMycobacterium tuberculosis dUTPase: insights into the catalytic mechanism 显示文摘 | Chan S Segelke B Lekin T Krupka H Cho US Kim MY So M Naranjo CM Rogers YC Park MS Waldo GS Pashkov I Cascio D Perry JL Sawaya MR | 2004 | J Mol Biol2004，341，2： | 1 |
| 16 | The discrete dynamics of symmetric competition in the plane显示文摘 | Jiang H Rogers T D | 1987 | Journal of Mathematical Biology1987，25，6： | 1 |
| 17 | Factors influencing mobility control by polymer solutions显示文摘 | Jenning R R Rogers J H West T J | 1976 | JPT1976，23，3： | 1 |
| 18 | The source and phosphatase activity of exoenzyme systems of com and tomato roots 显示文摘 | Rogers H T | 1942 | Soil Sci1942，54，： | 1 |
| 19 | Experiments in X-ray irradiation of gem stones显示文摘 | Pough F H Rogers T H | 1947 | American Mineralogist1947，32，12： | 1 |
| 20 | Maturation, fecundity and seasonality of reproduction of two commercially valuable cuttlefish, Sepia pharaonis and S. dollfusi , in the Suez Canal显示文摘 | Howaida R Gabr Roger T Hanlon Mahmoud H Hanafy Salah G El-Etreby | 1998 | Fisheries Research1998，，2： | 1 |
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