|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 4 | Pharmacokinetics of melamine in pigs following intravenous administration显示文摘 | RONALD E B GEOF S SHARON E M | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
| 5 | Methodology for Thermal Evaluation of Multichip Modules 显示文摘 | Lall Balwant S Guenin Bruce M Molnar Ronald J | 1995 | IEEE Trans Comp Packg Manufa Technol Part A1995，18，4： | 1 |
| 6 | Quantitative monitoring of gene expression patters with a complementary DNA microarray显示文摘 | Schena M Dari S Ronald W | 1995 | Science1995，270，： | 1 |
| 7 | A comparison of the catalytic activities of Ga13-, Al13-, GaAl12- and chromium-pillared interlayered clay minerals and Ga-H-ZSM-5 zeolite in the dehydrocyclodimerization of propane显示文摘 | Bradley S M Ronald A K | 1993 | Journal of Cataly- sis1993，142，： | 1 |
| 8 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 9 | Cyanide production by Pseudomonas fluorescens and Pseudomoas aeruginosa 显示文摘 | RONALD A A MORRISON S M | 1983 | Appl Miroobiol1983，45，： | 1 |
| 10 | Sorption and Flirtation of Metals Using Iron - oxide-coated Sand显示文摘 | MARK M Benjiamin RONALD S Sletten ROBERT P Bailey | 1996 | Water Res1996，30，： | 1 |
| 11 | Immunophenotypic markers and antiretroviral therapy (IMART):T cell activation and maturation help predict treatment response显示文摘 | Donna M Ronald J B Ryung S K | 2004 | JID2004，189，15： | 1 |
| 12 | Using assessment centre methods for measuring undergraduate business student outcomes 显示文摘 | RONALD E R BRONSTON T M DEIDRA J S | 2003 | Journal of Management Inquiry2003，，12： | 1 |
| 13 | Mechanical properties of Nylon bonded Nd-Fe-B permanent magnets显示文摘 | Monika G G Albert J S Ma B M Edgar L C Ronald O S | 2003 | Journal of Magnetism and Magnetic Materials2003，257，： | 1 |
| 14 | Effect of Pb on the mechanical properties of nanocrystalline AI 显示文摘 | Koteswararao V R Ronald O S Korukonda L M | 2006 | Scripta Materialia2006，55，： | 1 |
| 15 | Prevalence of complications of male circumcision in Anglophone Africa: a systematic review显示文摘 | Adamson S M Hans W P Ronald H M | 2007 | BMC Urol2007，7，4： | 1 |
| 16 | Recent advances in understanding lidnin biosynthesis显示文摘 | Ross W W John J M Ronald R S | 1998 | Annual Review of Plant Physiology and Plant Molecular Biology1998，49，： | 1 |
| 17 | Tenderness-An enzymatic view显示文摘 | Caroline M K Paul L S Ronald G B | 2010 | Meat Science2010，84，： | 1 |
| 18 | Use of Pi-5 (t) markers in marker assisted selection to screen for cultivars with resistance to Magnaporthe grisea 显示文摘 | Yi G Lee S K Hong Y K Cho Y C Nam M H Kim S C Han S S Wang G L Hahn T R Ronald P C Jeon J S | 2004 | Theoretical and Applied Genetics2004，109，5： | 1 |
| 19 | A neurotrophic model for stress- related mood disorders显示文摘 | Ronald S D Lisa M M | 2006 | Biol Psyehiatry2006，59，： | 1 |
| 20 | The carbon dioxide leakage from chambers measured using sulfur hexafluoride显示文摘 | David T Tingey Ronald S Waschmann Donald L Phillips David M Olszyk | 2000 | Environmental and Experimental Botany2000，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员